[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"digital-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:digital-health":723},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,41,76,105,157,184,208,235,258,285,312,335,356,383,425,449,480,517,534,561,584,607,634,672,698],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":16,"targetDuration":4,"studyType":19,"phases":4,"briefSummary":20,"conditions":21,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100637770",false,"NCT07617519","Changing Outpatient Diabetes Care With Remote-Patient-Monitoring: A Real World Evidence Study With Pre-Post Comparison","Inclusion Criteria:\n\n* All people with active clinical care at SDCC during each period and thereby included in the RPM.\n\nExclusion Criteria:\n\n* All people without active clinical care at SDCC during each period.","ALL",{"count":17,"type":18},12000,"ESTIMATED","OBSERVATIONAL","The goal of this observational pre-post study is to evaluate a remote-patient-monitoring-system (RPM-system) integrated within an electronic health record (EHR) system in a real world cohort of approximately 12.000 people with diabetes in an outpatient care setting. The main question it aims to answer is:\n\nWhether glycemic outcomes following integration of the RPM system into the EHR over a two-year period are non-inferior compared with outcomes observed prior to an ambulatory care restructuring (including a prototype of the RPM-system) in October 2024.\n\nParticipants are included in the RPM-system as part of their regular medical care for diabetes.",[22,23,24,25,26,27],"Diabetes","Diabetes Care","Diabetes Type 1","Diabetes Type 2","Remote Patient Monitoring","Digital Health","NOT_YET_RECRUITING","2026-06-22",{"date":31,"type":32},"2026-06-25","ACTUAL",{"date":34,"type":18},"2026-06",{"date":36,"type":18},"2028-07",{"name":38,"class":39},"Steno Diabetes Center Copenhagen","OTHER",1,{"id":42,"slug":4,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":40},"100631210","NCT07497711","Virtual Menstrual Pain Approaches in Females","Virtual Auricular Acupressure and Baduanjin Qigong Exercise for Preventing Menstrual Pain in Females: A Randomized Clinical Trial","AABQ","Inclusion Criteria:\n\n* 16 - 35 years of age\n* Regular menstrual cycles (28 days ± 7 days) in 3 months prior to enrollment\n* Two or more episodes of menstrual cramps in the past 2 months, scored at least 4 points on the worst pain item of the Brief Pain Inventory (BPI)\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Ability to download, install, and navigate the study-specific digital content and use its core functions for training, self-guided intervention administration, and data entry\n* Ability to understand the nature of the study and willingness to give informed consent.\n\nExclusion Criteria:\n\n* Uncontrolled neurological diseases, immunodeficiency, bleeding disorders, and allergies\n* The presence of another Axis I disorder not in remission\n* Lactating or pregnant, or those planning to become pregnant in the coming half year\n* Undergoing other trials for pain management during the study period\n* Plan to initiate other pain therapies for menstrual pain management in the proceeding 3 months","FEMALE","16 Years","35 Years",{"count":52,"type":18},145,"INTERVENTIONAL",[55,56],"PHASE2","PHASE3","This research study is testing two self-care approaches that may help prevent or reduce period pain in young females with recurrent painful menstrual cramps. Participants will be placed by chance into 1 of 3 groups: auricular acupressure, Baduanjin qigong, or a self-care education comparison group. The auricular acupressure and Baduanjin groups will receive online training and then practice the treatment on their own for 12 weeks. The main question is whether these two approaches can reduce the severity of menstrual pain. The study will also look at whether they can improve other symptoms that often happen with period pain, such as tiredness, poor sleep, anxiety, low mood, trouble concentrating, and reduced physical function. Researchers will also study stool and blood-related biological markers to better understand whether changes in gut bacteria and body metabolism may be linked to symptom improvement. A total of 145 participants will take part in the study at NTU, and any side effects or other safety concerns will be checked every week.",[59,60,61,27,62,63,64,65],"Pain (Visceral, Somatic, or Neuropathic)","Women of Reproductive Age","Mental Disorder","Acupressure","Traditional Exercise","Host-Gut Microbiota Interaction","Metabolomics","RECRUITING","2026-06-18",{"date":69,"type":32},"2026-06-23",{"date":71,"type":32},"2026-04-15",{"date":73,"type":18},"2029-03-20",{"name":75,"class":39},"Nanyang Technological University",{"id":77,"slug":4,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":53,"phases":85,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":40},"100629762","NCT07478887","Impact of the Corrie Lipids Digital Health Program on Lipid Optimization","Corrie Lipids Program: Optimizing LDL-Cholesterol by Improving Awareness, Access, and Achievement","Inclusion Criteria:\n\n* Age ≥18 years\n* Uncontrolled LDL-C per AHA\u002FACC guidelines\n* At least 1 major cardiovascular risk factor, including: high risk for ASCVD (individuals who meet criteria for Lipid-Lowering Therapy (LLT) based on ASCVD risk assessment using the most up-to-date guidelines), known ASCVD or subclinical ASCVD based on imaging, clinically diagnosed familial hypercholesterolemia or LDL-C ≥190 mg\u002FdL, diabetes mellitus, history of statin-associated side effects\n* Has a primary care physician and\u002For cardiologist who can prescribe lipid therapy\n* Owns a smartphone and agrees to the End User License Agreement to use the digital health app\n* Provided informed consent before initiation of study-specific activities\n\nExclusion Criteria:\n\n* Motor, cognitive, auditory, or visual impairment limiting technology use\n* Does not speak English\n* Malignancy (except nonmelanoma skin cancers or cervical or breast ductal carcinoma in situ within the previous 5 years)\n* Pregnancy (positive pregnancy test, highly sensitive urine or serum), plan to become pregnant or donate eggs, breastfeeding or plan to breastfeed\n* Likely to not be available to comply with all required study procedures to the best of the patient's and investigator's knowledge\n* History or evidence of any other clinically significant disorder, condition, or disease that, in the opinion of the investigator, would pose a risk to patient safety or interfere with the study evaluation, procedures, or completion","18 Years",{"count":84,"type":18},1000,[86],"NA","The overall objective is to evaluate the effectiveness and implementation of the Corrie Lipids Program, a comprehensive digital health initiative designed to address critical gaps in lipid-lowering as a component of ASCVD treatment by delivering an intervention that combines a patient-facing smartphone app, clinician education and coaching, and seamless incorporation into clinical workflows.\n\nResearchers plan to assess this multicenter digital health initiative in approximately 1,000 adults with uncontrolled LDL-C and elevated ASCVD risk using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. The study will examine whether the program improves LDL-C goal attainment, app engagement, prescribing patterns, and LDL-C monitoring, while also identifying barriers and facilitators to implementation across sites.",[89,90,91,27,92],"Cardiovascular Risk","LDL-C","Lipids","Implementation Science",[94,95],"Apolipoprotein B (apoB)","Lipoprotein-a (Lp(a)","2026-03-13",{"date":98,"type":32},"2026-03-18",{"date":100,"type":32},"2025-06-20",{"date":102,"type":18},"2027-12",{"name":104,"class":39},"Johns Hopkins University",{"id":106,"slug":4,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":53,"phases":114,"briefSummary":115,"conditions":116,"keywords":121,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":40},"100562395","NCT06602609","Remote Cardiovascular Monitoring in Post-TAVI Patients","Remote Acute Monitoring-based Same-day Discharge Strategy of Post Transcatheter Aortic Valve Implantation Patients Versus Standard Care at 30-Day Follow-up","TELE-TAVI","Inclusion Criteria:\n\n* Patient age must be 18 years or above.\n* Post-TAVI patients without serious complications hindering same-day discharge, including vascular, neurological, and cardiac postprocedural complications necessitating inpatient care:\n* Vascular: Controlled with adequate vascular hemostasis.\n* Neurological: Conscious and oriented, not under the effect of residual sedation.\n* Cardiac: No significant pericardial effusion.\n* Elective non-emergent patient admission and nonelective cases fitting discharge criteria.\n* Comfortable ambulation post-procedure.\n* The patient or their caregiver must have access to a smart device.\n* Ability to provide informed consent (the patient must be alert and oriented for consent).\n* Adequate social support.\n\nExclusion Criteria:\n\n* Hemodynamically unstable post-TAVI condition, periprocedural cardiac arrest, cerebral vascular accident, acute kidney injury (AKI) and major\u002Flife-threatening bleeding requiring blood transfusion.\n* Patients with a permanent (pre-existing or new) implanted pacing device.\n* Procedural failure in device delivery.\n* Major vascular access complications require patients to stay.\n* Inability to engage with the technology.\n* Significant communication barrier.",{"count":113,"type":18},216,[86],"The goal of this randomised clinical trial is to utilise a remote monitoring algorithm to gather essential clinical data, aiming to guide the management of post-Transcatheter Aortic Valve Implantation (TAVI) patients and reduce both postprocedural hospital length of stay and readmissions. This strategic integration of technology aims to address gaps identified in previous studies and enhance the effectiveness of post-TAVI patient care. One significant concern after TAVI is the development of heart conduction abnormalities on the ECG and abnormal rhythms, such as heart block, potentially requiring permanent pacemaker insertion. Addressing these rhythm issues is crucial for reducing the overall length of stay.\n\nThe main question it aims to answer is: Does a remote patient monitoring protocol-driven strategy reduce post-TAVI hospital length of stay and adverse events? Participants post-TAVI procedure and eligible for same-day discharge, as determined by their primary cardiologist, will be randomized upon informed consent into the active arm (remote monitoring) or control group (standard of care).\n\nParticipants in the active arm will: receive four remote monitoring devices. Receive support from a validated clinical decision-making algorithm for further management.\n\nParticipants in the control group will: adhere to the best standard of care as per current practice.\n\nResearchers will compare the active arm to the control group to see if the remote patient monitoring protocol-driven strategy reduces post-TAVI hospital length of stay and adverse events.",[117,118,27,119,120],"Aortic Valve Stenosis","Cardiac Conduction Disturbance","Transcatheter Aortic Valve Implantation","TAVI",[122,123,124,125,126,27,127,120,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147],"POST-TAVI","Hospital Length of Stay","Same-Day Discharge","Remote Monitoring","Ambulatory ECG","Valvular Heart Disease","TAVR","Medical Device","Hospital at Home","Home Health","Telemedicine","Virtual Health","ECG","EKG","RCT","Digital Innovation","Technology","Ambulatory","Cardiology","Post-Acute","Post Acute","Digital Technology","Electrocardiogram","Clinical Trials","Telehealth","Home Telemetry","2026-02-27",{"date":150,"type":32},"2026-03-03",{"date":152,"type":32},"2024-11-01",{"date":154,"type":18},"2028-07-01",{"name":156,"class":39},"Imperial College London",{"id":158,"slug":4,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":15,"minAge":163,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":19,"phases":4,"briefSummary":166,"conditions":167,"keywords":171,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":40},"100611150","NCT07236840","Self-administered Remote Neurological Examination Using Mobile Application in Patients With Brain Tumors","NEMO","Inclusion Criteria:\n\n1. Diagnosis of brain tumors (histopathology\u002F radiology).\n2. Age \\> 5 years\n3. Patient or caregiver have access to an android smart phone and is able to install the mobile application.\n4. Expected survival more than 6 months during study accrual.\n5. Signing patient consent or parent consent\u002F child assent form (as appropriate).\n\nExclusion Criteria:\n\n1. Patient or caregiver is not reliable to follow instructions or use the mobile application.\n2. Patient with severe cognitive or psychiatric issues causing difficulty in using the app or follow instructions.\n3. Karnofsky Performance Status (KPS) or Lansky Performance Status LPS) \\\u003C50.\n4. Terminal illness with expected life expectancy (\\\u003C6 months).","5 Years",{"count":165,"type":18},600,"The goal of this observational study is to evaluate the feasibility and accuracy of a self-administered remote neurological examination using the \"Iskhaa\" mobile application in patients with brain tumors aged above 5 years who are able to follow app-based instructions.\n\nThe main questions it aims to answer are:\n\n1. Development of a mobile application equipped with symptom assessment and recording videos as patients perform specific neurological tasks.\n2. Development and validation of the AI model to detect functional changes and predict subsequent neurological deterioration.\n\nParticipants will:\n\n1. Use the Iskhaa mobile application to perform guided self-neurological examinations following pre-recorded video instructions.\n2. Complete EORTC QLQ-C30 and BN20 questionnaires for quality of life assessment.\n3. Record and upload videos (e.g., speech, walking, limb movements) using their mobile camera for analysis.\n4. In Phase 1 (onsite), 100 participants will use the app under supervision to ensure usability and accuracy.\n5. In Phase 2 (offsite), 500 participants will use the app independently at home for monthly self-assessments, with reminders and follow-up support.\n6. Continue routine clinic visits every 3-6 months and imaging every 6-12 months as per standard clinical care.\n\nThe study will compare app-recorded data with physician assessments to determine agreement and validity of remote neurological monitoring using artificial intelligence analysis.",[168,169,170,27],"CNS Tumor","Artificial Intelligence (AI)","Glioma",[172,173,174],"neurological examination","mobile application","brain tumors","2026-02-21",{"date":177,"type":32},"2026-02-24",{"date":179,"type":32},"2026-02-20",{"date":181,"type":18},"2027-11-05",{"name":183,"class":39},"Tata Memorial Centre",{"id":185,"slug":4,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":190,"sex":15,"minAge":191,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":53,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":40},"100560230","NCT06574438","The Effectiveness of AIFIGA Program on Nursing Home Nursing Staff and Family and Residents'Health","The Effectiveness of Artificial Intelligence Family Involvement Generative Agent (AIFIGA) Program on Nursing Home Nursing Staff and Family and Residents'Health","Inclusion Criteria:\n\nAll resident-caregiver pairs meeting the inclusion criteria will be invited to join the study.\n\n1. residents aged ≥ 60 years, resident's family were aged equal or higher than 20 years.\n2. both residents and family can communicate in Mandarin or Taiwanese\n3. residents have a Mini-Mental State Examination (MMSE) score equal to or higher than 16 for residents with no formal education or higher than 24 for residents with at least a primary school education\n4. both residents and family agree to participate\n5. the family is a significant member of the resident, such as a caregiver.\n\nFor nurses and nursing aides:\n\n1. working in the selected nursing home who agree to participate in our program.\n2. aged equal or higher than 20 years.\n\nExclusion Criteria:\n\n\\-",true,"20 Years",{"count":193,"type":18},210,[86],"This study aims to develop and evaluate the longitudinal effectiveness of the Artificial Intelligence Family Involvement Generative Agent (AIFIGA) program in enhancing the health of nursing staff, family, and residents' health through the use of a sequential, mixed methods research design. The development of a real-time, interactive, and informative AIFIGA program that sparks innovation is necessary to achieve effective communication between families and nursing staff.\n\nIn Phase I, lasting 18 months, we will develop the AIFIGA program based on triangulate research design, observation and in-depth interview understanding the daily communication experiences and expectations from both families and nursing staff perception in Nursing Homes(NHs) after COVID-19, as well as our previous years' research results. The training data for AIFIGA will be derived from the collection of communication dialogues in these qualitative data. Furthermore, the intelligence of AIFIGA will be developed using publicly available large language models (LLMs).\n\nIn Phase II, spanning the next 18 months, we will evaluate the longitudinal effects of the AIFIGA program on the health of residents, families, and nursing staff, tracking changes over time (baseline, 1 month, 3 months, and 6 months). There will be two groups of participants: (a) an AIFIGA group that receives the AIFIGA program and uses it for 3 months, and (b) a control group that receives only routine care.",[197,198,27],"Family","Nursing Home","2026-02-05",{"date":201,"type":32},"2026-02-09",{"date":203,"type":32},"2024-09-24",{"date":205,"type":18},"2027-07",{"name":207,"class":39},"Chang Gung Memorial Hospital",{"id":209,"slug":4,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":19,"phases":4,"briefSummary":217,"conditions":218,"keywords":219,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":234},"100613349","NCT07265427","Trust in AI and Digitalization in Healthcare Across Generational Groups: A Comparative Study of Barriers and Facilitators Toward Equitable Adoption.","Acceptance and Perceived Benefits of Digitalization by Medical Assistants and Other Generational Groups (ANDI-MFA-2): \"Trust in AI and Digitalization in Healthcare Across Generational Groups: A Comparative Study of Barriers and Facilitators Toward Equitable Adoption\"","TRUST-AI","Inclusion Criteria:\n\n* Age 18 or older\n* Belonging to one of the defined participant groups\n* Consent to participate in the online survey\n* Ability to participate in the survey (e.g., sufficient German or English language skills)\n\nExclusion Criteria:\n\n* Individuals under 18\n* Inability to give informed consent\n* Illiteracy",{"count":216,"type":18},250,"This study aims to investigate differences in perception of barriers and facilitators of digitalization and Artificial Intelligence (AI) usage in healthcare across different generational groups (youth, working-age adults, and seniors). The results will help create practical recommendations for public health projects and consultants to support fair and inclusive use of new digital tools in healthcare. A cross-sectional online survey will be conducted among students at HAW, patients and employees in the rehabilitation center in Oldenburg, and seniors participating in the \"Digital im Alter\"(DIA) project.",[27,169],[169,220,221,222,223,224],"Digitalization","Trust","Barriers","Facilitators","Intergenerational Comparision","2025-12-12",{"date":227,"type":32},"2025-12-19",{"date":229,"type":32},"2025-11-24",{"date":231,"type":18},"2026-12-30",{"name":233,"class":39},"Jacobs University Bremen gGmbH",2,{"id":236,"slug":4,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":53,"phases":243,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":40},"100613319","NCT07265037","Integrated TCM - Western Medicine Strategy for Long - Distance Diabetes Management","Development of a New Integrated Strategy for Long-Distance and Full-Course Management of Diabetes Using Both Traditional Chinese and Western Medicine: A Combined Online and Offline Approach","Inclusion Criteria:\n\n* Presence of typical diabetes symptoms (polyuria, polydipsia, polyphagia, and unexplained weight loss) AND meeting any one of the following laboratory criteria: Fasting venous plasma glucose ≥ 7.0 mmol\u002FL, or Random plasma glucose ≥ 11.1 mmol\u002FL, or Glycated hemoglobin (HbA1c) ≥ 6.5%.\n* OR, meeting the following oral glucose tolerance test criteria:Fasting plasma glucose ≥ 7.0 mmol\u002FL AND 2-hour plasma glucose ≥ 11.1 mmol\u002FL after a 75g glucose load.\n\nExclusion Criteria:\n\n* Comorbidities that may prevent compliance with the study protocol, including but not limited to: active malignancy, rheumatic autoimmune diseases, severe infections, multiple organ failure, or psychiatric disorders.",{"count":242,"type":18},10000,[86],"The management of diabetes is of great value in reducing the risk of complications and alleviating the socioeconomic burden. Currently, the diabetes management models in China have not effectively integrated the advantages of traditional Chinese medicine (TCM) and Western medicine. They also fail to achieve intelligent and automated management, resulting in high management costs and low efficiency. Therefore, it is extremely urgent to explore a new, efficient, convenient, low - cost, and personalized long - distance, full - course, intelligent management model for diabetes that integrates TCM and Western medicine both online and offline.\n\nBased on this, our research group plans to rely on the pre - designed and developed Idata database. We will deeply integrate the diagnostic and treatment advantages of TCM constitution differentiation and Western medical examinations and laboratory tests, construct an automated follow - up path, and build an integrated online diabetes management platform for Internet hospitals, which consists of \"intelligent hardware + APP + cloud services + a back - end think - tank of TCM and Western medicine experts + a back - end professional management and care team\".\n\nThis initiative aims to blaze a new trail in the field of long - distance, full - course, and personalized management of diabetes through the synergy of TCM and Western medicine for Chinese diabetes patients. We expect to significantly reduce the incidence of diabetes complications, remarkably improve the overall health status and quality of life of patients, and bring unprecedented positive impacts on the well - being of diabetes patients.",[246,247,132,248,27],"Diabetes Mellitus, Type 2","Integrated Traditional Chinese Medicine and Western Medicine","Chronic Disease Management","2025-11-23",{"date":251,"type":32},"2025-12-04",{"date":253,"type":32},"2025-11-01",{"date":255,"type":18},"2026-05-31",{"name":257,"class":39},"Shanxi Bethune Hospital",{"id":259,"slug":4,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":15,"minAge":163,"maxAge":82,"enrollmentInfo":265,"targetDuration":267,"studyType":19,"phases":4,"briefSummary":268,"conditions":269,"keywords":273,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":283,"locationsCount":40},"100595326","NCT07030998","Wearable Technology and Machine Learning for Early Detection and Risk Assessment of Unacceptable Toxicities in a Paediatric Oncology Cohort","WEARABLES: Wearable Technology and Machine Learning for Early Detection and Risk Assessment of Unacceptable Toxicities in a Paediatric Oncology Cohort","WEARABLES","Inclusion Criteria:\n\n* Paediatric, adolescent or young adult diagnosis of cancer AND receiving therapy placing them at risk of infection\n* Receiving cancer treatment at The Royal Children's Hospital\n* Patients aged 5-18 years at time of the eligibility screening\n* If aged \\\u003C 16 years, parent or guardian able to provide consent\n* iPhone 8 or later (iOS must be up to date\u002Fupdated at time of enrolment)\n* At least 10MB of iPhone storage for WEARABLES app and data collection.\n* Willing and able to wear a wearable device for a period of 4 weeks (during waking hours).\n* Consent to data being shared to the WEARABLES app (owned by the research team).\n\nExclusion Criteria:\n\n* \\\u003C5 years of age.\n* \\\u003C16 years of age without guardian or parent consent.\n* Aged 16-18 and unable to provide consent.\n* Participant did not consent to wearing Apple Watch for a period of 4 weeks.",{"count":266,"type":18},150,"4 Weeks","Data collection study to establish a predictive model of infection observed during childhood cancer therapy using data captured by wearable technology.",[270,271,27,272],"Cancer","Infection","Wearable Devices",[270,274,271,275,276],"Paediatric","Treatment Toxicity","Wearable Device","2025-11-14",{"date":279,"type":32},"2025-11-17",{"date":281,"type":32},"2025-10-15",{"date":102,"type":18},{"name":284,"class":39},"Murdoch Childrens Research Institute",{"id":286,"slug":4,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":53,"phases":294,"briefSummary":295,"conditions":296,"keywords":300,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":234},"100576555","NCT06786819","Impact of a Technology Platform Based on Enhanced Recovery After(ERAS) Surgery on Length of Stay After Coronary Artery Bypass Grafting: Timely Project","Estudo Randomizado de Cluster Escalonado Para Avaliar o Impacto de Uma Plataforma tecnológica Baseada no ERAS (Enhanced Recovery After Surgery) no Tempo de permanência após Cirurgia de revascularização miocárdica: Projeto Tempos Certos - REPLICCAR III","REPLICCARIII","Inclusion Criteria:\n\n* Adults over 18 years old\n* Indication for primary isolated CABG (elective or urgent status)\n* Own a personal cell phone\n* Have internet access\n* Knowledgeable in using the device\n* Full understanding and agreement regarding the informed consent form (ICF)\n\nExclusion Criteria:\n\n* Indication for associated surgery\n* Glycosylated hemoglobin level greater than 8%\n* Creatinine clearance less than 30 mL\u002Fmin\n* Pre-operative atrial fibrillation or use of pre-operative anticoagulation\n* Hemoglobin less than 12 g\u002FdL\n* Users of illicit drugs\n* STS score greater than 4%\n* Physical or mental disabilities that prevent adherence to the protocol\n* Refusal by the patient or family member",{"count":293,"type":18},480,[86],"Cardiovascular diseases continue to be the leading cause of death worldwide. Among them, coronary artery disease has the greatest impact, being characterized as one of the main causes of death in Brazil over the last decade. One of the well-established treatments is coronary artery bypass grafting, which is the most performed among cardiac surgeries and, in our scenario, is primarily funded by the Unified Health System (SUS). The information obtained from the Paulista Registry of Cardiovascular Surgeries (REPLICCAR), in partnership with FAPESP, has been important for implementing improvements in the landscape of cardiac surgeries in the state of São Paulo. Although outcomes in cardiac surgery have improved due to the structuring and organization of quality programs, this is still not a reality at the national level. In a situation where data collection and quality initiatives play a central role in continuous improvement, generating value becomes essential for the sustainability of cardiac surgery programs. In this sense, the concept of Enhanced Recovery After Surgery (ERAS) has gained increasing traction. This concept is based on multidisciplinary protocols and scientific evidence, which help prepare patients for rapid recovery, resulting in reduced complications, shorter hospital stays, and, primarily, lower hospital costs. On the other hand, the increase in surgical waiting lists has also led to a rise in home mortality due to cardiac causes. Thus, among the various challenges imposed by the current scenario, the investigators believe that preparing patients for rapid recovery after coronary artery bypass grafting presents an opportunity for the sustainability of the healthcare system. Therefore, the aim of this project is to evaluate the impact of a technology platform based on ERAS on the postoperative recovery time of patients undergoing coronary artery bypass grafting in reference centers in the state of São Paulo, Timely Project - REPLICCAR III.",[297,298,299,27],"ERAS","Cardiac Surgery","Cardiac Surgery-CABG",[298,301,302,297,27],"CABG","ERASCS","2025-10-02",{"date":305,"type":32},"2025-10-03",{"date":307,"type":32},"2025-03-10",{"date":309,"type":18},"2026-09-01",{"name":311,"class":39},"University of Sao Paulo General Hospital",{"id":313,"slug":4,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":53,"phases":320,"briefSummary":321,"conditions":322,"keywords":323,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":40},"100593718","NCT07010081","Using Digital Health in a Postoperative Setting After Major Surgery: Survey Study","Using Digital Health in a Postoperative Setting After Major Surgery: a Prospective Single-center Quantitative Survey Study","Inclusion Criteria:\n\n* Surgical patients\n\n  * \\>18 years old, Undergone major surgery at Jessa Hospital Hasselt\n\nExclusion Criteria:\n\n* Unable to provide informed consent or request to not participate in the study\n* Cognitively incapable of understanding the study\n* No understanding of the Dutch language",{"count":319,"type":18},220,[86],"This study aims to explore patients' use of digital services for self-management of their health following major surgery at Jessa Hospital. Besides this, the study evaluates patients' ability to process and critically assess health information during recovery, their understanding of health concepts and risk factors, and their perception of data security and control over personal health information. Additionally, the study aims to examine patients' motivation to use digital services, their access to and trust in reliable digital health resources, and how well these services meet their individual needs. Furthermore, the study assesses the acceptability, appropriateness, and feasibility of using digital health tools in a post-operative setting, as well as evaluating the digital readiness of patients after surgery.",[27],[324,325],"Remote monitoring","Major surgery","2025-09-26",{"date":328,"type":32},"2025-10-01",{"date":330,"type":32},"2025-05-26",{"date":332,"type":18},"2027-05-01",{"name":334,"class":39},"Jessa Hospital",{"id":336,"slug":4,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":342,"enrollmentInfo":343,"targetDuration":4,"studyType":53,"phases":345,"briefSummary":346,"conditions":347,"keywords":348,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":353,"leadSponsor":355,"locationsCount":4},"100583843","NCT06881602","Remote Clinical Monitoring After Robotic Distal Pancreatectomy","Remote Clinical Monitoring After Robotic Distal Pancreatectomy: a Pilot and Feasibility Study","TOTEM","Inclusion Criteria:\n\n* 18-75 years old\n* Competent to provide informed consent\n* Fluent in Dutch\n* Cognitively capable of understanding and engaging with the study\n* Undergoing robotic distal pancreatectomy\n* Owing a smartphone or has a caregiver who can assist\n* Does not live alone\n* Have a valid national identification number\n\nExclusion Criteria:\n\n* Extended left pancreatectomy\n* Spleen-preserving procedure\n* Residing in a nursing home\n* Patients who are deemed unsuitable for the study by the physician based on clinical evaluation\n* Absence of informed consent or request to not participate in the study","75 Years",{"count":344,"type":18},20,[86],"This feasibility trial has three main objectives:\n\n* To investigate the impact of the transmural care pathway TOTeM on the Length of Stay (LOS) for patients undergoing robotic distal pancreatectomy.\n* To investigate the feasibility of the implementation of TOTeM for patients undergoing robotic distal pancreatic surgery, we will measure the recruitment rate by tracking the number of eligible patients who are approached for participation, the percentage who consent to join the study over a specified time period, and the adherence rate which describes how well participants follow the study protocol including the prescribed interventions or follow-up assessments.\n* Assessment of the potential changes in medical costs and outcomes for the purpose of performing a cost-effectiveness analysis from a hospital and patient perspective.",[27],[324,349],"Pancreatectomy",{"date":351,"type":32},"2025-09-29",{"date":328,"type":18},{"date":354,"type":18},"2027-12-31",{"name":334,"class":39},{"id":357,"slug":4,"hasResults":11,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":361,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":363,"targetDuration":4,"studyType":53,"phases":365,"briefSummary":366,"conditions":367,"keywords":372,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":378,"leadSponsor":380,"locationsCount":382},"100590724","NCT06971146","Nurse-Led Telehealth for Gout","Health Literacy-Based, Nurse-Led Telehealth Support for Gout Self-Management: the Danish Randomized GOUTCONNECT Trial","GoutConnect","Inclusion Criteria:\n\n* ≥18 years old\n* Fulfills ACR\u002FEULAR 2015 Gout Classification Criteria\n* Estimated Glomerular Filtration Rate (e-GFR) \\>30 ml\u002Fmin\n* Prescribed Allopurinol or Adenuric, and achieved two consecutive serum urate levels of two consecutive serum urate levels of ≤0.30 mmol\u002Fl for patients with tophi and ≤0.36 mmol\u002FL for patients without tophi\n* Have sufficient Danish reading and writing skills to understand information and complete questionnaires.\n\nExclusion Criteria:\n\n• Cognitively impaired, unable to understand or provide informed consent.",{"count":364,"type":18},200,[86],"The aim of this clinical trial is to evaluate whether nurse-led telehealth support helps individuals with gout better manage their condition and adhere to urate-lowering medication after discharge from a rheumatology clinic.\n\nEligible patients will be recruited from five rheumatology departments in the Central Denmark Region after achieving two consecutive target serum urate levels-below 0.36 mmol\u002FL, or below 0.30 mmol\u002FL for patients with tophi.\n\nParticipants will be adults with gout who meet specific medical criteria, are taking medications such as allopurinol or Adenuric, and are able to read and write Danish.\n\nParticipants will be randomly assigned to one of two groups:\n\n* Intervention group: nurse-led telehealth support.\n* Control group: usual care with follow-up by their general practitioner.\n\nThe primary goal is to support patients in maintaining healthy uric acid levels after 52 weeks.\n\nParticipants in the nurse-led group have the option to choose from four support options:\n\nI1: App-Based Support - an app provides information and reminders. I2: Letter Reminders - messages are sent via digital or postal mail. I3: Text Reminders - SMS messages are sent every three months. I4: Phone Support - nurses call three times a year to check in.",[368,369,370,146,27,371],"Health Literacy","Gout Arthritis","Gout Initiating Urate-loweringUrate-lowering Therapy","Adherence",[373],"self-managment","2025-09-17",{"date":376,"type":32},"2025-09-18",{"date":328,"type":18},{"date":379,"type":18},"2027-08-01",{"name":381,"class":39},"University of Aarhus",5,{"id":384,"slug":4,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":389,"targetDuration":4,"studyType":53,"phases":391,"briefSummary":392,"conditions":393,"keywords":415,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":40},"100585650","NCT06905119","Digital Transformation of Continuity of Care for Peripherally Inserted Central Catheters: SpadCare Experience","SpadCare","Inclusion Criteria:\n\n* Patients \\>18 years.\n* Sign the informed consent form.\n* Have a Smartphone and accept the use of the APP.\n* Patient with a PICC inserted by the Infusion and Vascular Access Team of the University Hospital of Navarra and with a planned use of at least one month.\n\nExclusion Criteria:\n\n* Patients with limitations in the use of digital resources or lack of Smartphone.\n* Patients who do not want to install the APP on their Smartphone\n* Patients who do not authorize access to their Computerized Medical Record (HCI).",{"count":390,"type":18},201,[86],"The study focuses on patients who require outpatient infusion of therapy (\"Infusions, Intravenous\"\\[Mesh\\]) \"Administration, Intravenous\"\\[Mesh\\] (\"Home Infusion Therapy\"\\[Mesh\\]) \"Parenteral Nutrition, Home\"\\[Mesh\\] via a peripherally inserted central catheter (PICC) (\"Central Venous Catheters\"\\[MeSH\\] \"Catheterization, Central Venous\"\\[MeSH\\] \"Catheterization, Peripheral\" \\[MeSH\\] \"Vascular Access Devices\"\\[Mesh\\] )",[394,395,396,397,398,399,400,401,402,403,404,405,406,407,27,408,409,410,411,412,413,414,132],"Infusions, Intravenous","Administration, Intravenous","Home Infusion Therapy","Parenteral Nutrition, Home","Central Venous Catheters","Catheterization, Central Venous","Catheterization, Peripheral","Vascular Access Devices","Patient Education as Topic","Patient Participation","User-Computer Interface","Smartphone","Mobile Applications","Computers, Handheld","Nursing","Care Givers","Delivery of Health Care","Home Nursing","Self Administration","Adverse Effects","Catheter-Related Infections",[400,401,402,132,406],"2025-09-11",{"date":418,"type":32},"2025-09-12",{"date":420,"type":32},"2023-05-04",{"date":422,"type":18},"2026-07-31",{"name":424,"class":39},"Fundacion Miguel Servet",{"id":426,"slug":4,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":53,"phases":433,"briefSummary":434,"conditions":435,"keywords":438,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":40},"100533696","NCT06229171","InTake Care: Development and Validation of an Innovative, Personalized Digital Health Solution for Medication Adherence Support in Cardiovascular Prevention","InTakeCare","Inclusion Criteria:\n\n* Adult (\\>18 years old) patients\n* History of essential hypertension\n* Treatment with at least one antihypertensive drug for which dedicated plasma essay is available\n* wireless internet connection available at patients' home\n* stable clinical conditions\n* written informed consent\n\nExclusion Criteria:\n\n* insufficient technological literacy to manage vocal assistant\n* dementia or significant psychiatric disorders\n* conditions significantly limiting vocal communication (deafness, significant speech disorders, poor knowledge of Italian language)\n* pregnancy or breastfeeding\n* active cancer (except basal cell skin carcinoma)\n* upper limb amputation",{"count":432,"type":18},206,[86],"Inadequate medication adherence (MA) in chronic conditions, including cardiovascular prevention, represents an important risk factor. The use of new IT technologies in this setting is supposed to be useful to improve patients' adherence, but currently available solutions have significant limitations, including lack of personalization and reliance on expensive ad hoc systems.\n\nThis interdisciplinary project aims to verify the hypothesis that in patients on chronic antihypertensive treatment MA can be improved through the implementation of a novel digital health solution for MA monitoring and support, based on inexpensive and user-friendly, commercially available technology (voice assistant), connected with web interface for the physician. The intervention will be personalized based on the creation of Personas, intended as multidisciplinary-based representations of different user types. This approach will be tested in a randomized clinical trial.",[436,437,27],"Hypertension","Treatment Adherence and Compliance",[439],"Personalized Medicine","2025-08-19",{"date":442,"type":32},"2025-08-21",{"date":444,"type":32},"2024-10-01",{"date":446,"type":18},"2026-04-01",{"name":448,"class":39},"Istituto Auxologico Italiano",{"id":450,"slug":4,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":454,"eligibilityCriteria":455,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":456,"targetDuration":4,"studyType":53,"phases":458,"briefSummary":459,"conditions":460,"keywords":466,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":40},"100591740","NCT06984354","Digitally Delivered Treatments to Reduce Chronic Low Back Pain","NOTUS Trial: A Randomised Controlled Trial of Two Digitally Delivered Treatment Options for Chronic Back Pain","NOTUS","Inclusion Criteria:\n\n* Experiencing non-specific chronic low back pain (LBP), defined as pain between the 12th rib and the buttock crease.\n* LBP with or without leg pain (in case of leg pain, LBP is worse than leg pain).\n* Currently consulting with a general practitioner for their non-specific chronic LBP across Australia.\n* Mean pain intensity score on the Numeric Rating Scale ≥ 3\u002F10 in the past week.\n* A score of at least moderate on question 8 of the physical functioning component of the SF-36 questionnaire.\n* Access to a mobile device with minimal requirements to download the study app (300MB).\n* An internet connection to access the mobile app functionalities.\n* Able to understand English via reading and audio materials.\n\nExclusion Criteria:\n\n* Known or suspected specific spinal (e.g., radiculopathy, fracture) or specific non-spinal non- (e.g., tumour, infection) pathology.\n* Less than six months post-spinal surgery.\n* Scheduled for major surgery during the program or the follow-up period.\n* Known or suspected serious psychiatric condition not being treated by a health professional that would impact adherence to the trial activities.\n* Known or suspected sight or hearing problems that would limit access to the intervention components (reading and listening using headphones).",{"count":457,"type":18},720,[86],"This study aims to evaluate the effectiveness of pain education and clinical hypnosis delivered via a mobile app compared to a guideline-informed factsheet for reducing pain and disability in people experiencing chronic low back pain attending general practice.",[461,462,463,27,464,465],"Low Back Pain","Chronic Pain (Back \u002F Neck)","General Practice (GP), Primary Care Settings","Hypnosis, Chronic Pain Management","Patient Education",[467,27,468,469,470],"Back Pain","Hypnosis","Pain Education","Chronic Pain","2025-07-16",{"date":473,"type":32},"2025-07-20",{"date":475,"type":32},"2025-06-02",{"date":477,"type":18},"2028-05-26",{"name":479,"class":39},"Neuroscience Research Australia",{"id":481,"slug":4,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":190,"sex":15,"minAge":487,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":53,"phases":490,"briefSummary":491,"conditions":492,"keywords":497,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":511,"leadSponsor":513,"locationsCount":516},"100593817","NCT07011368","Empowering Healthy Lifestyle Personalised Intervention to Prevent and Control Obesity: The HealthyW8 Project","Empowering Healthy Lifestyle Behaviour Through Personalized Intervention Portfolios to Prevent and Control Obesity During Vulnerable Stages of Life: The HealthyW8 Project.","HealthyW8","Inclusion Criteria:\n\n* Overweight (BMI between 25-30 kg\u002Fm\\^2)\n* To have a smart phone\n\nExclusion Criteria:\n\n* Individuals with manifest chronic diseases\n* Individuals with cognitive diseases\n* Individuas not able to lead an independent life","7 Years",{"count":489,"type":18},2720,[86],"The goal of the HealthyW8 study (an intervention study) is:\n\nTo assess the usefulness and effects of a digital-based healthy lifestyle recommender system (HRLS) on the prevention of obesity in the following propulations: schoolchildren (5-10 y) and their parents, young adults (18-25 y) and elders (\\>65 y).\n\nThe main questions it aims to answer are:\n\nOutcome 1: To select and validate a tool-assisted 3-mo intervention (mostly digital) by iteratively testing the HLRS on reducing risk of overweight\u002Fobesity among the described age groups.\n\nOutcome 2: To assess the effect of 1-y interventions (mostly digital) with the HLRS described and further iteratively improved previously (outcome 1) on reducing risk of overweight\u002Fobesity at described ages.\n\nResearchers will compare the intervention group before the intervention (baseline) and after it (3-mo intervention trial), or control group (standard care) vs. Intervention group (1-y intervention) to see changes on changes in overweight\u002Fobesity, and related parameters (body composition and biomarkers).\n\nParticipants will follow the HLRS recommendations (meal plans, physical activity and sleep pattern measures and recommendations, assessment of behavioural\u002Fpsychological aspects, and motivational features through digital devices), which will be assessed by means of measurement of body weight, body composition, and biomarkers.",[493,494,495,27,496],"Obesity Prevention","Obesity and Overweight","Obesity and Obesity-related Medical Conditions","Behavioural Science Interventions to Improve Health Equity",[498,499,500,501,502,503,504,505,506],"Healthy lifestyle recommender system","digital empowerment","health literacy","personalised prevention","pre-obesity biomarkers","mHealth","Human Digital Twin","behavior change techniques","physical activity","2025-06-27",{"date":509,"type":32},"2025-07-01",{"date":509,"type":18},{"date":512,"type":18},"2028-06-30",{"name":514,"class":515},"Fundació d'investigació Sanitària de les Illes Balears","OTHER_GOV",13,{"id":518,"slug":4,"hasResults":11,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":522,"targetDuration":4,"studyType":53,"phases":524,"briefSummary":525,"conditions":526,"keywords":527,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":532,"leadSponsor":533,"locationsCount":4},"100593716","NCT07010055","Using Digital Health in a Postoperative Setting After Major Surgery: Semi-structured Interview Study","Using Digital Health in a Postoperative Setting After Major Surgery: a Prospective Single-center Qualitative Semi-structured Interview Study",{"count":523,"type":18},30,[86],"This study aims to evaluate whether patients recognize a need for a remote monitoring care pathway during the post-operative period following major surgery at Jessa Hospital by means of a semi- structured interview. Besides this, the study explores patient perceptions and willingness to participate in digital monitoring care pathways, identifies potential barriers to adoption, and addressing concerns related to safety, data security, and privacy. Additionally, the study aims to assess patient needs regarding parameter collection, technology usage, and the overall functionality of digital monitoring systems, while evaluating the perceived usefulness of such a pathway in post-operative care.",[27],[324,325],"2025-06-06",{"date":530,"type":32},"2025-06-08",{"date":475,"type":18},{"date":332,"type":18},{"name":334,"class":39},{"id":535,"slug":4,"hasResults":11,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":541,"targetDuration":4,"studyType":53,"phases":542,"briefSummary":543,"conditions":544,"keywords":547,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":559,"locationsCount":40},"100592839","NCT06998654","Feasibility of a Digital Intervention for Patients Frequently Admitted to Psychiatric Acute Wards","Feasibility of a Digital Intervention for Patients Frequently Admitted to Psychiatric Acute Wards: the MULI App Study","MULI","Inclusion Criteria patients:\n\n* older than 18 years\n* reside in one of the study municipalities\n* admitted into the Muli service\n* have had at least three admissions into the psychiatric acute ward in the last 12 months\n\nInclusion criteria, healthcare workers:\n\n\\- staff members at the local psychiatric hospital who respond to patient contacts made through the app\n\nExclusion criteria, staff:\n\n\\- staff members at the local psychiatric hospital who rare not tasked with responding to patient contacts made through the app.",{"count":7,"type":18},[86],"This qualitative feasibility study investigates a digital health app designed for patients who are frequently admitted to the psychiatric acute ward, to facilitate crisis support outside of office hours to avoid unnecessary readmissions, as well as self-harm. As this is a novel app to be implemented in an already existing service, key uncertainties regarding the intervention content and its delivery needs to be addressed before potentially conducting a full-scale trial, or, alternatively, to inform further intervention refinement. Such uncertainties are appropriate to explore in a feasibility study according to the Medical Research Council (MRC) framework for the development and evaluation of complex interventions.\n\nThere is a need to investigate whether the app is acceptable and useful to the patients using it, and to the healthcare providers who respond to it. There is also a need to know whether the healthcare providers responding to the app find the task manageable. The context in which the staff are to deliver the intervention, i.e. the in-bed ward, may be subject to different barriers, such as a staff shortage due to sick leave and heavy workload in the ward. Such barriers are essential to identify ahead of possible future trials in other contexts.",[545,27,546],"Mental Health Help-Seeking","Readmissions",[548,549,550,551],"Digital mental health intervention","self help","crisis support","readmissions","2025-05-29",{"date":554,"type":32},"2025-05-31",{"date":556,"type":18},"2025-06-12",{"date":558,"type":18},"2026-12-31",{"name":560,"class":39},"Haukeland University Hospital",{"id":562,"slug":4,"hasResults":11,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":566,"eligibilityCriteria":567,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":53,"phases":570,"briefSummary":571,"conditions":572,"keywords":575,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":40},"100545448","NCT06382038","Smart Technology Facilitated Patient-centered Care for Patients With Pulmonary Thromboembolism","Smart Technology Facilitated Patient-centered Care for Patients With Pulmonary Thromboembolism：A Multicenter, Randomized Controlled Trial","SmaPE","Inclusion Criteria:\n\n* Inpatients aged ≥18 years;\n* （2）PTE confirmed through imaging examinations, meeting at least one of the following criteria: a.Newly diagnosed PTE during the current hospitalization; b. Prior PTE with imaging evidence of residual thrombus.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Previous PTE combined with CTEPH;\n* Mental retardation or a combination of other serious illnesses that make them incapable of living on their own;\n* Inability to use smartphones, computer tablets and other smart devices;\n* Being pregnant or breastfeeding;\n* Have participated in similar trials or are undergoing other clinical trials.",{"count":569,"type":18},2972,[86],"Smart technologies, such as wearable devices, mobile technologies, and artificial intelligence, are being investigated for use in health management. These technologies have the potential to be applied in disease pre-warning, decision-making support, health education, and healthcare maintenance. They are expected to address the challenges in managing thrombosis, improve access to high-quality medical resources in various regions, and enhance the development of a network for thrombosis rescue and treatment prevention.\n\nThe objective of this study is to evaluate the impact of mobile venous thromboembolism application (mVTEA) based patient-centered management of pulmonary thromboembolism (PTE) on the long-term outcome of PTE patients, in order to enhance clinical practice and establish a foundation of evidence for managing patients with PTE.",[573,574,27],"Venous Thromboembolism","Pulmonary Thromboembolisms",[573,574,27],"2025-05-27",{"date":554,"type":32},{"date":579,"type":18},"2025-10-08",{"date":581,"type":18},"2026-10-31",{"name":583,"class":39},"Navy General Hospital, Beijing",{"id":585,"slug":4,"hasResults":11,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":589,"eligibilityCriteria":590,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":591,"targetDuration":4,"studyType":53,"phases":593,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":598,"lastUpdatePostDateStruct":599,"startDateStruct":601,"completionDateStruct":603,"leadSponsor":604,"locationsCount":606},"100591711","NCT06983977","Increasing Physical Activity Among Medical Inpatients by Digital Nudging of Patients and Staff","Increasing Physical Activity Among Medical Inpatients by Digital Nudging of Patients and Staff - A Cluster Randomised Multicentre Study","IPAMINA","Inclusion Criteria:\n\n* Admitted to one of the participating wards\n* Has understood and signed informed consent\n* Reads and understands Danish, Faroese, Greenlandic or English\n\nExclusion Criteria:\n\n* Has an expected hospitalisation less than 24 hours after potential recruitment\n* Is not able to give informed consent to participate in the study\n* Has allergy towards band aid\n* Not able to (shortly) stand in an upright position even with maximal assistance\n* There are contraindications for the patient to mobilise or be physically active due to unstabilized acute medical conditions, including, but not limited to, acute aortic dissection, -myocardial infarction, -pulmonary embolism, -sepsis.\n* There are ethical concerns regarding the patients' participation in the study, including, but not limited to, the patient being:\n\n  * In the terminal phase of life\n  * In a crisis state regarding their disease\u002Fsituation and deemed unfit for participation\n\nTo ensure medically responsible inclusion of patients, the project personnel will consult and confer with the treatment responsible medical doctor, or their delegate, before including a potential participant for the trial.",{"count":592,"type":18},400,[86],"Sedentary behaviour among medical inpatients is strongly associated with hospital-associated functional decline and poses a severe threat to patients' functional capacity and independency. High human and socioeconomic costs underline the urgency to find solutions to this world-wide problem.\n\nObjective: This multicentre study, including a total of 400 patients from Copenhagen, Aalborg, Tórshavn, and Nuuk, will assess the effect of a digital intervention that aims to reduce sedentary behaviour and increase physical activity in medical inpatients.\n\nIntervention: Digital feedback and nudging regarding the patients' physical activity levels to patients and healthcare staff Design: Stepped-wedge cluster randomised multicentre trial Primary outcome: Daily average time of patients' physical activity (minutes).",[596,597,27],"Physical Activity","Inpatients","2025-05-21",{"date":600,"type":32},"2025-05-25",{"date":602,"type":32},"2025-05-19",{"date":102,"type":18},{"name":605,"class":39},"Bispebjerg Hospital",4,{"id":608,"slug":4,"hasResults":11,"nctId":609,"briefTitle":610,"officialTitle":611,"acronym":612,"eligibilityCriteria":613,"healthyVolunteers":190,"sex":15,"minAge":614,"maxAge":4,"enrollmentInfo":615,"targetDuration":4,"studyType":19,"phases":4,"briefSummary":617,"conditions":618,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":4},"100588684","NCT06944600","Impact of Sleep Disorders and Digital Support on Older People's Health","The Role of Sleep Disorders in the Motoric and Cognitive Trajectories of Older Physically Frail Sarcopenic and Healthy Active Subjects","SOMNUS-DARE","Inclusion Criteria:\n\n* Age ≥ 65 years;\n* MMSE score adjusted by age and education ≥ 25\u002F30;\n* Absence of mobility-disability;\n* Absence of need for assistance with Basic Activities of Daily Living (according to the ICFSR International Clinical Practice Guidelines).\n\nExclusion Criteria:\n\n* Individuals with specific clinical conditions that make the intervention unsafe (I.e., severe diseases, unstable health status);\n* Individuals whose adherence to the protocol might be low due to clinical (E.g., cognitive impairment, dialysis) and non-clinical (E.g., plans to relocate out of the study area within the next 3 years) reasons;\n* Individuals unable or unwilling to provide informed consent;\n* Consumption of more than 14 alcoholic drinks per week \\[one alcoholic drink (equal to 14.0 grams of pure alcohol) corresponds to 36 cc of beer (5% alcohol content), 24 cc of malt liquor (7% alcohol content), 15 cc of wine (12% alcohol content), 4.5 cc of distilled spirit or liquor (40% alcohol content)\\];\n* Difficulty in communicating with the study staff due to speech, language, or (non-corrected) hearing and vision problems;\n* Severe arthritis (E.g., awaiting joint replacement) that would interfere with the ability to fully participate in the study;\n* Lung disease requiring regular use of supplemental oxygen;\n* Severe cardiovascular disease (including New York Heart Association \\[NYHA\\] class III or IV, clinically significant congestive heart failure and valvular disease, history of cardiac arrest, presence of an implantable defibrillator or pacemaker, uncontrolled angina);\n* Upper and\u002For lower extremity amputation;\n* Peripheral arterial disease Lériche-Fontaine 3 or 4;\n* Renal disease requiring dialysis;\n* Current enrolment in another study involving lifestyle, nutrition, or pharmaceutical interventions;\n* Further medical, psychiatric, or behavioural factors that in the judgment of the principal investigator may interfere with the study participation;\n* Further possible illnesses affecting the life expectancy and reducing it to less than 24 months, corresponding to the study's length;\n* Clinical judgment concerning safety or non-compliance, as well as the conditions for which the use of the Sleep Profiler is not recommended (sensitivity of skin or scalp and\u002For open wounds on the forehead or scalp, allergic reactions to extended exposure to synthetic fabrics (e.g., polyester, rayon), upper respiratory infection or congestion, head circumference less than 21 or greater than 25 inches, forehead vertical measurement (from top of eyebrows to hairline) less than or equal to 2 inches or horizontal measurement (from hairline to hairline) less than or equal to 6 inches).\n* SPPB score \\\u003C3 at baseline.","65 Years",{"count":616,"type":18},300,"The goal of this observational study is to learn about the effects of sleep disorders on health and ageing in older people over the age of 65.\n\nThe main question it aims to answer is: How do sleep disorders impact the motoric and cognitive ageing trajectories of older individuals? Participants will undergo a set of instrumental, laboratory and clinical diagnostic examinations to comprehensively assess the impact of sleep disorders on health.",[619,620,621,622,623,27,624],"Sleep Disorders","Frailty","Cognitive Impairment","Quality of Life","Ageing","Multidisciplinary Approach","2025-04-17",{"date":627,"type":32},"2025-04-25",{"date":629,"type":18},"2025-05",{"date":631,"type":18},"2027-11",{"name":633,"class":39},"University of Parma",{"id":635,"slug":4,"hasResults":11,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":190,"sex":15,"minAge":641,"maxAge":4,"enrollmentInfo":642,"targetDuration":4,"studyType":53,"phases":644,"briefSummary":645,"conditions":646,"keywords":649,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":666,"completionDateStruct":668,"leadSponsor":670,"locationsCount":4},"100565811","NCT06647030","Personalized NFTs as a Trial Participation Incentive","A Pilot Study on the Use of Personalised Non-Fungible Token (NFT) Artwork Generated From Digital Therapeutics (DTx) as a Trial Participation Incentive (Avatar.DTx)","AvatarDTx","Inclusion Criteria:\n\n* Healthy\n* Agree to audio-recording of the interview\n* Meet the cognitive criteria for adequate mental capacity as determined by the MMSE.\n\nExclusion Criteria:\n\n* Difficulty to understand and read English (the DTx text and audio are in English)\n* Significant hearing impairment\n* Evidence\u002Fdiagnosis of severe cognitive impairment\n* Inability to complete the study at the judgement of the investigators","21 Years",{"count":643,"type":18},15,[86],"NFTs are blockchain-based digital and physical assets traded on digital marketplaces. Current and exploratory NFT use cases include art, collectibles, in-game items, real estate, ticketing, events, fintech, licenses, IDs, and healthcare. NFT marketplaces, online games, virtual worlds, and open-source coding platforms use NFTs to incentivize participation. In trials, where the effectiveness of financial remuneration to increase trial participation is unclear, NFTs could encourage involvement. Considering the increasing opportunities for blockchain technology and NFT use in both the economy and society, we present a pilot study protocol to gauge the interest and feasibility of using NFTs as payment for trial participants, the first of its kind to our knowledge. Additionally, as the global population ages and chronic diseases become more prevalent, innovative solutions to sustain engagement in longevity-focused interventions are needed. Harnessing CURATE.AI, an indication-agnostic artificial intelligence (AI) platform that modulates the intensity of interventions to generate truly personalized profiles - or digital avatars, we will develop N-of-1 learning trajectory profiles for fifteen healthy volunteers trained on the CURATE.DTx, a digital therapeutic (DTx) platform. The profiles will be artistically modified and minted for the participants in the Ethereum blockchain, whereafter the recipient can choose to keep, display, or trade their NFT. Through interviews, we will evaluate the interest and acceptability of NFTs as an incentive for trial participation. This pioneering exploration connects AI-driven personalized medicine with inventive blockchain solutions. Our research aims to advance the field of digital therapeutics and pave the way for novel approaches to patient-centered care and incentivization strategies in clinical trials.",[647,27,648],"Healthy","Incentive Interventions",[145,650,651,652,653,654,655,656,657,658,659,660,661,662],"Blockchain","Digital Therapeutics","DTx","Non-Fungible Tokens","NFTs","CURATE.AI","CURATE.DTx","AI-driven","Digital Avatar","Incentives","Patient Engagement","N-of-1","Single Participant","2025-04-08",{"date":665,"type":32},"2025-04-11",{"date":667,"type":18},"2025-07-02",{"date":669,"type":18},"2026-06-02",{"name":671,"class":39},"Institute for Digital Medicine (WisDM)",{"id":673,"slug":4,"hasResults":11,"nctId":674,"briefTitle":675,"officialTitle":676,"acronym":677,"eligibilityCriteria":678,"healthyVolunteers":190,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":679,"targetDuration":4,"studyType":53,"phases":680,"briefSummary":681,"conditions":682,"keywords":685,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":689,"lastUpdatePostDateStruct":690,"startDateStruct":692,"completionDateStruct":694,"leadSponsor":696,"locationsCount":4},"100586053","NCT06910371","Digital Detox Study","Digital Detox Study: A Randomized Controlled Trial","RESET","Inclusion Criteria:\n\n* healthy subjects\n* greater-equal 18 years\n* sufficient German skills\n* using a smartphone daily 3 hours or more\n* no ongoing psychotherapy, psychological or psychopharmacological treatment\n\nExclusion Criteria:\n\n* Age under 18 years\n* insufficient German skills\n* Smartphone use less than 3 hours per day\n* ongoing psychotherapy, psychological or psychopharmacological treatment",{"count":364,"type":18},[86],"The Digital Detox study is designed as a randomized controlled trial (two unblinded parallel groups) to examine the effects of reducing smartphone screentime on mental health. After giving informed consent, participants will be screened for eligibility. Inclusion criteria are adult subjects (greater-equal 18 years) using their smartphone daily for 3 hours or more, with sufficient German skills and no ongoing psychotherapy, psychological or psychopharmacological treatment. For eligibility screening, participants have to upload a screenshot of their smartphone screen time of the last week, have to state about mental health disorders (self-report) and their sociodemographic variables (age, gender, country of residence, education and professional status, urban\u002Frural nature of place of residence), and have to fill out the following questionnaires: depressive symptoms (PHQ-9), well-being (WHO-5), sleep quality (ISI), stress (PSQ-20), loneliness (three-item loneliness scale), physical activity, and smartphone usage behavior.\n\nIf the inclusion criteria are met, participants will be randomized to the intervention or control group. The intervention consists of a three-week screen time reduction to a maximum of 2 hours per day for 3 consecutive weeks. The control group continues to use their smartphones as usual during this time. At the beginning of the study (=baseline T0), all participants will complete the following primary outcome measures (depressive symptoms (PHQ-9), well-being (WHO-5), sleep quality (ISI), stress (PSQ-20)) and secondary outcome measures (loneliness (three-item loneliness scale), craving (CEQ-F), physical activity). Both groups will also complete items on loneliness and physical activity twice during the intervention (after the first and second week of the intervention) to monitor changes in these variables during the intervention. After the three weeks of intervention (post-intervention T1), both groups will again fill out the the same outcome measures as for T0. After the 3-week intervention, there are no further restrictions regarding the participants' smartphone screen time. Follow-up (T2) will be after 3 more weeks and the same outcome measures as for T0 and T1 will be collected.\n\nThe weekly smartphone screen time is assessed via self-reporting and screenshot upload. Information is also provided on the weekly activations of the smartphone and a screenshot is uploaded of the most frequently used apps. All data is collected weekly for the previous week.\n\nThe study will be performed entirely via a smartphone app (ESMIra), which is designed especially to run longitudinal studies.\n\nPrimary hypotheses:\n\n* H1: Reducing smartphone use to a maximum of 2 hours\u002Fday over 3 weeks leads to a difference in the depressive symptoms of the intervention participants before and after participating in the intervention.\n* H2: Reducing smartphone use to a maximum of 2 hours\u002Fday over 3 weeks leads to a difference in the the sleep quality of the intervention participants before and after participating in the intervention.\n* H3: Reducing smartphone use to a maximum of 2 hours\u002Fday over 3 weeks leads to a difference in perceived stress of the intervention participants before and after participating in the intervention.\n* H4: Reducing smartphone use to a maximum of 2 hours\u002Fday over 3 weeks leads to a difference in the well-being of the intervention participants before and after participating in the intervention.\n* H5: The reduction in smartphone use to a maximum of 2 hours\u002Fday over 3 weeks led to a difference in depressive symptoms between the control and intervention groups at the post-intervention time point.\n* H6: The reduction in smartphone use to a maximum of 2 hours\u002Fday over 3 weeks led to a difference in sleep quality between the control and intervention groups at the post-intervention time point.\n* H7: The reduction in smartphone use to a maximum of 2 hours\u002Fday over 3 weeks led to a difference in perceived stress between the control and intervention groups at the post-intervention time point.\n* H8: The reduction in smartphone use to a maximum of 2 hours\u002Fday over 3 weeks led to a difference in well-being between the control and intervention groups at the post-intervention time point.",[683,27,684],"Prevention","Smartphone Addiction",[686,687,688],"digital detox","screen time reduction","mental health","2025-03-27",{"date":691,"type":32},"2025-04-04",{"date":693,"type":18},"2025-03-31",{"date":695,"type":18},"2025-06-09",{"name":697,"class":39},"Danube University Krems",{"id":699,"slug":4,"hasResults":11,"nctId":700,"briefTitle":701,"officialTitle":702,"acronym":4,"eligibilityCriteria":703,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":4,"enrollmentInfo":704,"targetDuration":4,"studyType":53,"phases":706,"briefSummary":707,"conditions":708,"keywords":712,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":714,"lastUpdatePostDateStruct":715,"startDateStruct":717,"completionDateStruct":719,"leadSponsor":721,"locationsCount":4},"100578920","NCT06817564","AI-driven Personalized Exercise Feedback Program on Exercise Adherence in Traumatic Brain Injury","Effects of an AI-driven Personalized Exercise Feedback Program on Exercise Adherence and Health Outcomes in Patients with Traumatic Brain Injury","Inclusion Criteria:\n\n* Eligible participants are patients aged over 18 with mild TBI (GCS 13-15)\n* who can walk independently,\n* reside in the Greater Taipei area,\n* and possess sufficient Chinese or Taiwanese language proficiency to understand the trial\n* complete self-administered questionnaires.\n\nExclusion Criteria:\n\n* Exclusion criteria include individuals with severe medical conditions (e.g., respiratory failure, epilepsy, psychiatric disorders), musculoskeletal or neurological impairments\n* hindering physical activity in the 6-minute walk test,\n* cognitive impairments (MMSE \\\u003C 24),\n* frontal lobe injuries or penetrating injury causing significant psychological dysfunction.\n* Patients regularly engaging in moderate-to-high-intensity aerobic exercise or participating in other studies will also be excluded to avoid bias.",{"count":705,"type":18},125,[86],"This study aims to develop and evaluate an AI-driven Personalized Exercise Feedback Program (AI-PEF) to enhance exercise adherence and health outcomes in mTBI patients.\n\nMethods: AI-PEF integrates the transtheoretical model and self-determination theory with machine learning algorithms to provide real-time, personalized feedback. A phased randomized controlled trial will be conducted: Phase I evaluates feasibility and acceptability through Delphi methods with expert consensus and patient feedback; Phase II validates preliminary outcomes with 30 participants in a 2-arm randomized trial; and Phase III assesses the program's impact on adherence, sleep quality, depressive symptoms, and quality of life with 90 participants in a 3-arm randomized trial.",[709,710,711,27],"Traumatic Brain Injury","Exercise","AI (Artificial Intelligence)",[713],"AI-Driven Personalized Exercise Program","2025-02-08",{"date":716,"type":32},"2025-02-12",{"date":718,"type":18},"2025-03-01",{"date":720,"type":18},"2031-08-31",{"name":722,"class":39},"National Defense Medical Center, Taiwan",""]