[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dystrophia-myotonica-1\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dystrophia-myotonica-1":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100624915",false,"NCT07415837","Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies","Dystro-miR1","Inclusion Criteria:\n\n* Age: Participants must be older than 2 years of age\n* Consent: Participants (or their legal guardians) must provide free and informed consent,. For children, the consent is oral for those under 6 years old and written for those over 6,.\n* Social Security: Every participant must be affiliated with the French social security system.\n* Participants must have a diagnosed neuromuscular pathology : the eligible pathologies are Myotonic Dystrophy Type 1 (DM1 or Steinert's disease), Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (DMB), or congenital myopathies or are healthy participants.\n\nExclusion Criteria:\n\n* Refusal to participate expressed by the subject or their parental authority.\n* Engaging in intense and unusual physical effort within 10 days before the blood draw.\n* Current use of any treatment with systemic, muscular, or cardiac effects that could interfere with the study's biological results.\n* Subjects or their legal guardians who are under tutelage, curatorship, deprived of liberty, or under judicial protection.\n* Women who are pregnant or breastfeeding.\n* The presence of an additional pathology that, in the judgment of the clinician, could interfere with the biological findings",true,"ALL","2 Years",{"count":19,"type":20},104,"ESTIMATED","INTERVENTIONAL",[23],"NA","The study aims to find out if a specific blood molecule called miR-1, can be used as a biomarker to track the health of patients with certain muscle diseases.\n\nMicroRNAs (miRs) are small messengers that help control how cells grow and stay healthy. Some of these, like miR-1, are specifically found in muscles and the heart. Research shows that levels of miR-1 are often abnormal in people with muscle-wasting conditions, but more information are needed to understand how this relates to the severity of the disease.\n\nThe main goal is to compare the blood levels of miR-1 between four different groups at different ages and severities:\n\n1. Patients with Duchenne or Becker muscular dystrophy (DMD\u002FDMB).\n2. Patients with Myotonic Dystrophy Type 1 (Steinert's disease).\n3. Patients with congenital myopathies.\n4. Healthy volunteers (control group). The main objective is to assess if miR-1 levels can accurately show how a muscular disease is progressing.",[26,27,28,29],"Duchenne \u002F Becker Muscular Dystrophy","Dystrophia Myotonica 1","Congenital Myopathies","Healthy Participants",[31,32,33],"biomarkers","neuromuscular diseases","micro-RNAs","RECRUITING","2026-02-24",{"date":37,"type":38},"2026-02-25","ACTUAL",{"date":40,"type":38},"2026-02-11",{"date":42,"type":20},"2029-03",{"name":44,"class":45},"University Hospital, Clermont-Ferrand","OTHER",1,{"id":48,"slug":4,"hasResults":10,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":10,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":46},"100239721","NCT02398786","Myotonic Dystrophy Family Registry","MDFR","Inclusion Criteria:\n\n* Diagnosed with congenital, juvenile-onset or adult onset DM1 or DM2 (confirmed by clinical exam or genetic test)\n\nExclusion Criteria:\n\n* Not diagnosed with DM, unaffected family members",{"count":54,"type":20},3500,"5 Years","OBSERVATIONAL","The Myotonic Dystrophy Family Registry (MDFR) is an online, patient-entered database that collects information on myotonic dystrophy (DM) to aid researchers in developing new, effective treatments and help identify participants for research studies and clinical trials.",[59,60,61,62,63,27,64,65,66,67,68,69,70,71,72,73],"Myotonic Dystrophy","Congenital Myotonic Dystrophy","Myotonic Dystrophy 1","Myotonic Dystrophy 2","Dystrophia Myotonica","Dystrophia Myotonica 2","Myotonia Dystrophica","Myotonic Dystrophy, Congenital","Myotonic Myopathy, Proximal","PROMM (Proximal Myotonic Myopathy)","Proximal Myotonic Myopathy","Steinert Disease","Steinert Myotonic Dystrophy","Steinert's Disease","Myotonia Atrophica","2024-11-19",{"date":76,"type":38},"2024-11-21",{"date":78,"type":4},"2013-02",{"date":80,"type":20},"2030-02",{"name":82,"class":45},"Myotonic Dystrophy Foundation",""]