[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endogenous-cushing-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endogenous-cushing-syndrome":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100549170",false,"NCT06430528","A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement","Inclusion Criteria:\n\n* Endogenous Cushing syndrome, either following surgery or not candidates for surgery\n* Under consideration to receive osilodrostat as part of their clinical care\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Treatment with other investigational drugs within 30 days or five half-lives (whichever is longer).\n* A history of hypersensitivity to osilodrostat or therapies of a similar chemical class.","ALL","18 Years","75 Years",{"count":18,"type":19},12,"ESTIMATED","OBSERVATIONAL","The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach).\n\nThe investigators are also evaluating new biomarker steroids to reflect adequate osilodrostat dosing, the durability and safety, and clinical improvement during treatment.",[23,24,25],"Endogenous Cushing Syndrome","Adrenal Insufficiency","Hypercortisolism",[27,28,29,30],"Osilodrostat","Glucocorticoid","Methylprednisolone","Medrol","RECRUITING","2025-08-14",{"date":34,"type":35},"2025-08-20","ACTUAL",{"date":37,"type":35},"2024-07-19",{"date":39,"type":19},"2027-08",{"name":41,"class":42},"University of Michigan","OTHER",""]