[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"external-ventricular-drainage-associated-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:external-ventricular-drainage-associated-infection":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100622196",false,"NCT07380477","VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site","CSF Lactate and Ventriculostomy Associated Infections in Patients With Acute Brain Injury - a Prospective, Observational Cohort Study.","LACTIC","Inclusion Criteria:\n\n* Age \\>18 years\n* EVD in situ\n* Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark\n* Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage\n\nExclusion Criteria:\n\n* Patient or closest relatives do not understand written and spoken Danish or English\n* Patients transferred to Rigshospitalet with an EVD\n* Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)\n* Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission\n* Patients with primary or secondary brain cancer\n* Patients died or in palliative care","ALL","18 Years",{"count":19,"type":20},148,"ESTIMATED","6 Months","OBSERVATIONAL","This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:\n\n1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection;\n2. compare proximal and distal sample results obtained from an external ventricular drain;\n3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.",[25,26,27,28],"Acute Brain Injury","Hydrocephalus","External Ventricular Drain","External Ventricular Drainage Associated Infection","RECRUITING","2026-01-28",{"date":32,"type":33},"2026-02-02","ACTUAL",{"date":35,"type":33},"2025-01-15",{"date":37,"type":20},"2029-10-01",{"name":39,"class":40},"Rigshospitalet, Denmark","OTHER",""]