[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fragmentomics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fragmentomics":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100623636",false,"NCT07399210","Noninvasive Detection of Lung Nodule Malignancy Using cfDNA Fragmentomics","A Prospective Clinical Study Evaluating the Noninvasive Use of Circulating Cell-Free DNA Fragmentomics to Differentiate Benign and Malignant Lung Nodules, With Emphasis on Small Nodules.","SHC2408","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Positive for lung nodules on low-dose spiral CT (LDCT) meeting one of the following criteria:\n\nSolid or part-solid nodules ≥ 5 mm and ≤ 20 mm; Pure ground-glass nodules ≥ 8 mm and ≤ 30 mm; In cases of multiple nodules, the largest nodule (by maximum diameter) must meet these criteria;\n\n* Participants whose lung nodule status (benign or malignant) can be clinically confirmed;\n* No cancer-directed therapy (e.g., chemotherapy, radiotherapy, immunotherapy, cell therapy) within the past 3 months;\n* Able to provide a 5 mL peripheral blood sample prior to any treatment;\n* Voluntary signing of informed consent after full explanation of the study.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding;\n* Current or past diagnosis (within the past 5 years) of malignant tumors (excluding patients with early-stage lung cancer who have undergone surgery but still have multiple evaluable nodules), or with severe heart disease, serious liver or kidney disorders, or significant bone marrow hematopoietic dysfunction;\n* History of organ transplantation or blood transfusion within the past 3 months;\n* History of seropositivity for human immunodeficiency virus (HIV);\n* Any other condition deemed inappropriate for study participation by the investigators.","ALL","18 Years",{"count":19,"type":20},240,"ESTIMATED","1 Month","OBSERVATIONAL","The goal of this observational study is to learn if cfDNA fragmentomics can noninvasively diagnose whether lung nodules are benign or malignant in adults with imaging-detected lung nodules.",[25,26],"Lung Cancer (Diagnosis)","Fragmentomics",[26,28,29,30,31],"Lung Cancer(Diagnosis)","cfDNA","Small Nodule","Non-invasive","RECRUITING","2026-02-08",{"date":35,"type":36},"2026-02-10","ACTUAL",{"date":38,"type":36},"2024-08-21",{"date":40,"type":20},"2026-08-21",{"name":42,"class":43},"Baohui Han","OTHER",""]