[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frozen-shoulder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frozen-shoulder":645},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,40,63,88,112,140,169,194,218,243,276,296,316,339,369,394,415,443,468,489,516,544,573,599,620],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100643922",false,"NCT07667556","The Combined Effect of Mulligan Mobilization, Pain Neuroscience-Based Training, and Core Stabilization Exercises in Frozen Shoulder Patients","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Diagnosis of adhesive capsulitis confirmed by an orthopedic surgeon or a physical medicine and rehabilitation physician\n* Presence of shoulder pain and limitation of shoulder range of motion\n* Ability to communicate verbally\n* Ability to understand study procedures and educational content\n* Willingness to participate and provide written informed consent\n* Mini-Mental State Examination (MMSE) score of 24 or higher\n* Ability to attend treatment and assessment sessions regularly\n\nExclusion Criteria:\n\n* MMSE score below 24\n* Severe cognitive impairment\n* Severe psychiatric disorders\n* Active infectious disease\n* Active malignancy\n* Uncontrolled cardiovascular disease\n* Presence of a cardiac pacemaker\n* Contraindications to transcutaneous electrical nerve stimulation (TENS)\n* Neurological disorders that may affect participation or outcomes\n* Systemic diseases that may interfere with the safe implementation of the intervention\n* Inability to comply with the study protocol or attend scheduled sessions","ALL","18 Years","65 Years",{"count":19,"type":20},36,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this randomized controlled study is to investigate the effects of a combined rehabilitation program consisting of Mulligan Mobilization with Movement (MWM), Pain Neuroscience Education (PNE), and core stabilization exercises in individuals with adhesive capsulitis (frozen shoulder).\n\nThe main questions this study aims to answer are:\n\nDoes the combination of Mulligan mobilization, Pain Neuroscience Education, and core stabilization exercises reduce pain in individuals with adhesive capsulitis? Does this combined intervention improve shoulder range of motion, shoulder function, quality of life, scapular dyskinesis, and pain catastrophizing compared with conventional physical therapy?\n\nParticipants diagnosed with adhesive capsulitis will be randomly assigned to one of two groups. The intervention group will receive Mulligan mobilization, Pain Neuroscience Education, and core stabilization exercises, while the control group will receive conventional physical therapy, including TENS, hot-pack application, passive joint mobilization, and stretching exercises. Both groups will participate in treatment sessions three times per week for six weeks. Outcome measures will be assessed at baseline and after completion of the 6-week intervention period.",[26],"Frozen Shoulder","RECRUITING","2026-06-19",{"date":30,"type":31},"2026-06-25","ACTUAL",{"date":33,"type":31},"2026-04-21",{"date":35,"type":20},"2026-06",{"name":37,"class":38},"Yeditepe University","OTHER",1,{"id":41,"slug":4,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":4},"100642602","NCT07644884","Effects of Deltoid Strengthening Exercises in Patients With Adhesive Capsulitis","Effects of Deltoid Strengthening Exercises on Pain, Range of Motion, Muscle Strength and Disability in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* • Both male and female gender\n\n  * Subjects with age ranging from 40 to 60 years\n  * Subjects with stage II and III adhesive capsulitis\n\nExclusion Criteria:\n\n* • Subjects with rotator cuff tears\n\n  * Subjects with glenohumeral arthritis","40 Years","60 Years",{"count":49,"type":20},48,[23],"Adhesive capsulitis, also known as frozen shoulder, is a musculoskeletal condition that causes significant shoulder pain and restricted joint mobility. It affects the glenohumeral joint and is commonly seen in individuals between the ages of 40 and 60 year. It affects 3 to 5% of the general population with a higher prevalence among females and patients with diabetes or thyroid disorders. Adhesive capsulitis progresses in four stages: painful, freezing, frozen, and thawing, and the condition may persist for 1 to 2 years. This study aims to determine the effects of Deltoid Strengthening Exercises on pain, range of motion, muscle strength and disability in patients with Adhesive Capsulitis.",[26],"NOT_YET_RECRUITING","2026-06-08",{"date":56,"type":31},"2026-06-12",{"date":58,"type":20},"2026-06-06",{"date":60,"type":20},"2026-11-06",{"name":62,"class":38},"Riphah International University",{"id":64,"slug":4,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":21,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100631212","NCT07497737","OMT for Adhesive Capsulitis","Osteopathic Manipulative Treatment as an Adjunct Therapy for Adhesive Capsulitis","Inclusion Criteria:\n\n* patients diagnosed with adhesive capsulitis who have not received prior treatment for it\n\nExclusion Criteria:\n\n* patients with contraindications to corticosteroid injections (uncontrolled diabetes, active infection, bleeding disorders, or corticosteroid hypersensitivity)\n* patients diagnosed with adhesive capsulitis who have received (or are currently receiving) treatment for it","89 Years",{"count":71,"type":20},300,[73],"PHASE4","The goal of this clinical trial is to learn if Osteopathic Manipulative Treatment (OMT) is an effective addition to treatment of adhesive capsulitis. OMT is a non-invasive treatment in which a doctor gently moves and stretches muscles, joints, and tissues manually. Adhesive capsulitis is more commonly known as \"frozen shoulder\" and describes a shoulder that becomes stiff, painful, and limited in its motion due to some structural change in the joint. The main questions it aims to answer are:\n\nIs recovery faster when OMT is added to regular treatment? Are patients that underwent OMT more satisfied with their treatment?\n\nResearchers will compare patients who underwent OMT to patients who did not to see if OMT is an effective additional treatment for frozen shoulder.\n\nParticipants will:\n\n* Be assigned to one of the four experimental groups\n* Visit clinic and\u002For physical therapy to undergo the treatments associated with their group:\n\n  1. standard course of prescribed physical therapy\n  2. standard course of prescribed physical therapy and an injection of an anti-inflammatory and anesthetics in the shoulder\n  3. standard course of prescribed physical therapy and (up to) 4 OMT sessions\n  4. standard course of prescribed physical therapy, an injection of an anti-inflammatory and anesthetics in the shoulder, and (up to) 4 OMT sessions.\n* Visit clinic 1 month, 3 months, 6 months, and 1 year after treatment is complete\n* Complete a survey about how satisfied they are with their treatment 1 month, 3 months, 6 months, and 1 year after it is complete",[76,26],"Adhesive Capsulitis of the Shoulder",[78,76,26],"Osteopathic Manipulative Treatment (OMT)",{"date":80,"type":31},"2026-06-09",{"date":82,"type":20},"2026-08-01",{"date":84,"type":20},"2028-05-01",{"name":86,"class":38},"University Hospitals Cleveland Medical Center",3,{"id":89,"slug":4,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":95,"minAge":46,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":21,"phases":98,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":39},"100614340","NCT07278323","Frozen Shoulder and Hormone Replacement Therapy","Hormone Replacement Therapy as an Adjunct Treatment for Adhesive Capsulitis of the Shoulder (Frozen Shoulder) in Peri- and Postmenopausal Women","FSHRT","Inclusion Criteria:\n\n* Diagnosis of adhesive capsulitis of the shoulder\n\nExclusion Criteria:\n\n* History of hormone sensitive cancer\n* Bilateral adhesive capsulitis of the shoulder\n* Currently using hormonal treatments including contraceptives","FEMALE",{"count":97,"type":20},60,[73],"The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle. Frozen shoulder refers to the condition a doctor diagnosed the participant with regarding shoulder pain, stiffness, and progressive loss of range of motion. Age-related menstrual cycle changes, known as perimenopause and\u002For menopause, refers to a change or stoppage of monthly menstrual cycles. Other symptoms participants may be experiencing include vaginal dryness, hot flashes, or night sweats. Hormone replacement therapy (HRT) refers to medicine with female hormones in it. For this study, HRT will be in the form of a patch that goes on the skin and a daily oral pill. Participants will be randomly assigned to receive either HRT plus standard care, or only standard care. Follow-up tests will be completed at 6 months of treatment to assess participant progress.",[76,26],[26,102,103],"Hormone Replacement Therapy","Perimenopause","2026-06-04",{"date":54,"type":31},{"date":107,"type":31},"2026-01-15",{"date":109,"type":20},"2026-12",{"name":111,"class":38},"University of California, San Francisco",{"id":113,"slug":4,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":119,"targetDuration":4,"studyType":21,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":139},"100624998","NCT07416916","Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder","Ultrasound-Guided Intra-Articular Versus Systemic Corticosteroid Injection for Frozen Shoulder: A Multicenter, Blinded, Randomized Controlled Trial","CUSIS-FS","Inclusion Criteria (all must be met):\n\n1. Symptom duration ≤9 months; clinically diagnosed unilateral primary (idiopathic) frozen shoulder (including diabetes-associated frozen shoulder).\n2. Age 18 to 65 years.\n3. Worst shoulder pain in the past 24 hours (NRS-WP, 0-10) ≥4.\n4. Passive range of motion (ROM) limitation of the affected shoulder: compared with the contralateral normal shoulder, a decrease of ≥30° in at least two of the following three directions: forward flexion, abduction, and external rotation with the arm at the side.\n5. Radiographic exclusion of other shoulder pathology: Affected-shoulder anteroposterior (AP) radiograph excludes glenohumeral osteoarthritis, calcific tendinopathy, and other structural abnormalities; and axillary view and\u002For scapular Y (outlet) or transthoracic view excludes glenohumeral dislocation.\n\nExclusion Criteria (any of the following):\n\n1. Secondary frozen shoulder due to thyroid disease, cardiovascular disease, stroke, radiotherapy, prior neurosurgical or breast surgery, etc. (diabetes excluded from this item); or frozen shoulder secondary to major shoulder trauma requiring medical care (e.g., fracture, dislocation, rotator cuff tear).\n2. Confirmed or highly suspected full-thickness or massive rotator cuff tear causing functional pseudoparalysis (e.g., positive Jobe test with marked strength loss).\n3. Local infection of the affected shoulder or any contraindication to shoulder injection (e.g., uncorrected bleeding risk\u002Fcoagulopathy).\n4. Contraindication to corticosteroid therapy (e.g., poorly controlled diabetes, systemic infection).\n5. Prior manipulation under anesthesia, arthroscopic capsular release, or open surgical release for frozen shoulder on the affected shoulder.\n6. Any corticosteroid treatment via any route within the past 3 months (including shoulder injection).\n7. Requires long-term or intermittent corticosteroid use for other conditions (e.g., autoimmune disease such as rheumatoid arthritis, acute asthma exacerbations).\n8. Bilateral frozen shoulder, or contralateral history of frozen shoulder not yet fully recovered.\n9. Conditions significantly affecting upper-limb function assessment or ability to perform rehabilitation (e.g., marked limb disability).\n10. Pregnant or breastfeeding.\n11. Lacks the cognitive ability to comply with study procedures.\n12. Does not reside in the region served by the participating hospital(s) (anticipated inability to complete follow-up).\n13. Compensation claims (e.g., work-related injury, traffic accident) or ongoing legal disputes\u002Flitigation.",{"count":120,"type":20},528,[73],"The goal of this clinical trial is to determine if a gluteal muscle injection of compound betamethasone is as effective as an ultrasound-guided intra-articular injection in treating frozen shoulder (adhesive capsulitis) in adults aged 18 to 65. The main questions it aims to answer are:\n\n* Is gluteal injection as effective as ultrasound-guided intra-articular injection for improving shoulder function and reducing pain?\n* What are the side effects of each treatment method? Researchers will compare these two injection methods.\n\nParticipants will:\n\n* Receive one injection at baseline and will be followed up for 12 weeks\n* Complete shoulder function assessments\n* Perform home rehabilitation exercises",[26],[125,126,127,128,129],"frozen shoulder","intramuscular injection","compound betamethasone","ultrasound guidance","intra-articular injection","2026-05-29",{"date":132,"type":31},"2026-06-01",{"date":134,"type":31},"2026-02-23",{"date":136,"type":20},"2031-01",{"name":138,"class":38},"Second Affiliated Hospital, School of Medicine, Zhejiang University",9,{"id":141,"slug":4,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":39},"100533757","NCT06229964","Frozen Shoulder Treatment With Intra-Articular Corticosteroid Injection and Suprascapular Nerve Block","A Double Blinded Randomized Controlled Trial (RCT) Exploring the Additional Effect of a Suprascapular Nerve Block in Combination With an Intra-Articular Corticosteroid Injection in Patients With Frozen Shoulder","FROSTBLOCK","Inclusion Criteria:\n\n* Written informed consent to participate in the study must be obtained from the subject prior to initiation of any study-mandated procedure\n* Suffering from Frozen Shoulder, defined as: Frozen shoulder is a self-limiting disease characterized by pain and functional restriction in both active and passive shoulder motion lasting more than 1 month, for which radiographic findings of the shoulder joint are unremarkable.\n* Dutch or French speaking persons\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Subjects with posttraumatic or postsurgical stiff shoulder syndrome\n* History of trauma at the onset of symptoms\n* Subjects with rheumatologic or neurologic disease involving the shoulder\n* Subjects with cervical radiculopathy\n* Coagulation disorder\n* Hypersensitivity to local anesthetics or MRI contrast agent\n* Inability to understand the study procedures\n* Psychiatric illness\n* Pregnancy\n* Subjects who have received prior SSNB in the homolateral shoulder\n* Subjects who have received an IACI in the homolateral shoulder in the 3 months before inclusion• Systematic yeast infections\n* Hypovolaemia\n* Infections at the injection site\n* Medical history of malignant hyperthermia, major conduction disorders, acute cardiac decompensation, shock conditions, convulsions\n\nControl subjects for the diagnostic accuracy part of the study protocol\n\n* Inclusion criteria:\n* Written informed consent to participate in the study must be obtained from the sub-ject prior to initiation of any study-mandated procedure\n* Subjects suffering from shoulder pain that do not fulfill the diagnostic criteria of Frozen Shoulder\n* Dutch or French speaking persons\n* Age ≥ 18 years\n* Contralateral shoulder of Frozen Shoulder subjects\n* Exclusion criteria\n* Subjects with posttraumatic or postsurgical stiff shoulder syndrome\n* History of trauma at the onset of symptoms\n* Subjects with rheumatologic or neurologic disease involving the shoulder\n* Subjects with cervical radiculopathy\n* Coagulation disorder or treatments with anticoagulants\n* Hypersensitivity to MRI contrast agent\n* Inability to understand the study procedures\n* Psychiatric illness\n* Pregnancy\n* Systematic yeast infections\n* Hypovolaemia\n* Infections at the injection site\n* Medical history of malignant hyperthermia, major conductin disorders, acute cardi-ac decompensation, shock conditions, convulsions","99 Years",{"count":149,"type":20},110,[23],"Frozen shoulder remains a challenging disease to treat as pain and loss of range of motion can persist for many months or even years. This loss of function can have a severe impact on the patient's activities, participation and overall quality of life.\n\nThe use of ultrasound-guided (USG) suprascapular nerve blocks (SSNB) and\u002For intra-articular corticoid injections (IACI) has been supported by many studies. However, double blinded randomized clinical trials using a combination of SSNB and IACI are rare.\n\nThe primary objective of this study is to compare the effectiveness of a glenohumeral IACI combined with a SSNB, compared to a glenohumeral IACI combined with a sham SSNB. Outcome measures of interest are shoulder-related disability reported by the patients, shoulder pain and shoulder stiffness. These outcome parameters will be compared between both treatment arms with an intention-to-treat analysis.\n\nAs key secondary objectives, the investigators aim to identify which physical examination tests, or combinations of those, are correlated with MRI diagnostic criteria and favor a more positive evolution. Finally, through predictive analysis the investigators will try to establish which patients benefit the most from the combined SSNB + IACI.",[26,153],"Adhesive Capsulitis",[26,76,155,156,157,158,159,160],"Intra-articular corticosteroid injection","ultra-sound guided injection","suprascapular nerve block","Joint Diseases","Musculoskeletal Diseases","Bursitis","2026-05-28",{"date":132,"type":31},{"date":164,"type":31},"2025-02-28",{"date":166,"type":20},"2028-05-31",{"name":168,"class":38},"Universitair Ziekenhuis Brussel",{"id":170,"slug":4,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":21,"phases":177,"briefSummary":178,"conditions":179,"keywords":183,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":190,"leadSponsor":192,"locationsCount":39},"100640595","NCT07607691","Ultrasound-Guided PENG Block for Chronic Shoulder Pain","Evaluation of the Analgesic Efficacy and Functional Outcomes of Ultrasound-Guided PENG Block in Chronic Shoulder Pain","Inclusion Criteria:\n\n* Age 18 years or older.\n* Patients presenting with chronic shoulder pain lasting longer than 3 months.\n* Initial pain intensity score greater than 4 on the Numerical Rating Scale (NRS \\> 4).\n* Patients who have not responded to conservative or medical treatments.\n* Voluntary acceptance of the ultrasound-guided shoulder PENG block treatment and compliance with the scheduled follow-up protocol.\n\nExclusion Criteria:\n\n* Patients currently using anticoagulants or diagnosed with coagulation disorders (bleeding diathesis).\n* Patients with psychomotor or cognitive disorders that prevent cooperative evaluation.\n* Presence of active bacterial infection, open wounds, or infectious discharge at the planned needle injection site.\n* History of shoulder surgery at the intervention site within the last 6 months.\n* Known allergy or hypersensitivity to local anesthetics (lidocaine) or corticosteroids (dexamethasone).\n* Pregnant or breastfeeding patients.\n* Patients who reject the procedure or fail to comply with the scheduled follow-up visits.",{"count":176,"type":20},45,[23],"The purpose of this prospective, observational study is to evaluate the clinical and functional outcomes of ultrasound-guided Pericapsular Nerve Group (PENG) block in patients suffering from chronic shoulder pain. Chronic shoulder pain is a highly prevalent musculoskeletal problem that significantly restricts daily activities and diminishes the patient's quality of life. While conservative treatments and various interventional injections are widely used, long-term efficacy can be limited, and systemic side effects may occur. The shoulder PENG block is a novel regional analgesia technique that specifically targets the articular (sensory) branches of the nerves innervating the shoulder joint capsule without affecting the motor branches. In this single-center study, a total of 45 eligible adult patients with chronic shoulder pain who did not respond to conservative medical treatments will receive an ultrasound-guided PENG block as part of their routine clinical care. The procedure will be performed under sterile conditions using a combination of local anesthetic (lidocaine) and dexamethasone. Patient pain levels will be assessed using the Numerical Rating Scale (NRS), shoulder disability and functional status will be measured using the Shoulder Pain and Disability Index (SPADI), and overall patient satisfaction will be evaluated using the Global Perceived Effect (GPE) score. All parameters will be documented at baseline (before the procedure) and at follow-up visits on the 1st week, 4th week (1 month), and 3rd month post-procedure. The investigators aim to determine the efficacy, duration of effect, and safety profile of this intervention.",[180,181,26,160,182],"Chronic Shoulder Pain","Pericapsular Nerve Group Block (PENG Block)","Rotator Cuff Disorders",[184,185],"shoulder pain","pericapsular nerve group block","2026-05-21",{"date":188,"type":31},"2026-05-26",{"date":132,"type":20},{"date":191,"type":20},"2026-10-15",{"name":193,"class":38},"Ankara City Hospital Bilkent",{"id":195,"slug":4,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":15,"minAge":201,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":21,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":39},"100618840","NCT07336849","Transcatheter Arterial Embolization Using Nexsphere-F for Chronic Shoulder Pain Refractory to Conservative Treatment","A Single-center, Prospective, Open Label Randomized Clinical Trial to Evaluate the Efficacy and Safety of Transcatheter Arterial Embolization Using 'Nexsphere-F' in Patients With Adhesive Capsulitis of the Shoulder Joint Refractory to Conservative Treatment.","TAE-FROST","Inclusion Criteria:\n\n* Patients who have voluntarily signed a written informed consent form after receiving an explanation of the purpose, methods, and potential effects of the clinical trial\n\n  * Patients aged between 19 and 85 years\n\n    * Patients with pain persisting for more than 3 months in the affected area and with a history of receiving physical therapy, analgesics\u002Fanti-inflammatory medications, or local injection treatments\n\n      * Patients with a measured shoulder joint range of motion (ROM) of less than 90 degrees ⑤ Patients who agree not to receive any conservative treatment other than those permitted in this clinical trial (physical therapy, medication \\[NSAIDs, opioid analgesics, acetaminophen\\], intra-articular injections such as hyaluronic acid)\n\n        * Patients who are willing to comply with the treatment and procedures of the clinical trial and participate in all follow-up evaluations through hospital visits or telephone surveys\n\nExclusion Criteria:\n\n* Patients with a history of surgery on the shoulder joint targeted for the clinical trial prior to screening\n\n  * Patients suspected of having a full-thickness rotator cuff tear\n\n    * Patients with bleeding disorders or coagulopathies (e.g., idiopathic thrombocytopenic purpura, hemophilia, disseminated intravascular coagulation)\n\n      * Patients with advanced atherosclerosis or vasospasm in the arm vessels, or those expected to have such conditions\n\n        * Patients with a known hypersensitivity to gelatin\n\n          ⑥ Patients with a known hypersensitivity to contrast media\n\n          ⑦ Patients who are pregnant or breastfeeding\n\n          ⑧ Patients with a localized infection at the pain site\n\n          ⑨ Patients deemed inappropriate for participation by the investigator due to ethical concerns or potential impact on the clinical trial results","19 Years","85 Years",{"count":204,"type":20},44,[23],"Evaluation of the efficacy and safety of transcatheter arterial embolization using 'Nexsphere-F' for pain relief in patients with adhesive capsulitis of the shoulder joint that does not respond to conservative treatment.\n\nThis study aims to investigate the efficacy and safety of transcatheter arterial embolization using embolic agents in patients with adhesive capsulitis of the shoulder joint. This is a single-center, prospective, open-label, randomized clinical trial.",[76,26,208],"Shoulder Adhesive Capsulitis","2026-05-18",{"date":211,"type":31},"2026-05-19",{"date":213,"type":31},"2025-09-18",{"date":215,"type":20},"2027-08-31",{"name":217,"class":38},"Chung-Ang University Hosptial, Chung-Ang University College of Medicine",{"id":219,"slug":4,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":225,"sex":95,"minAge":16,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":228,"phases":4,"briefSummary":229,"conditions":230,"keywords":231,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":4},"100640526","NCT07603089","Exploring the Link Between Menopause, Glucose Control, and Frozen Shoulder in Women","Exploring the Association Between Menopausal Status, Metabolic Health, and Frozen Shoulder in Women: a Cross-sectional Observational Study","MENO-FROST","Part 1\n\nInclusion criteria:\n\n• Any women \\> 18 years with a history of frozen shoulder diagnosed by a clinician\n\nExclusion criteria:\n\n• Any women without a clear previous diagnosis of frozen shoulder\n\nPart 2:\n\nInclusion criteria:\n\n* Perimenopausal women (self-assessment)\n* Aged 40-60 years\n* Diagnosed with FS within the last 12 months OR\n* Matched controls (women aged 40-60 years without FS).\n\nExclusion criteria:\n\n* Diabetes mellitus,\n* Thyroid dysfunction,\n* Secondary FS (e.g. posttraumatic),\n* Use of medications influencing hormonal or metabolic parameters (e.g. hormone replacement therapy \\[HRT\\].",true,{"count":227,"type":20},340,"OBSERVATIONAL","Background\n\nFrozen shoulder (FS) is a common condition and affects how the shoulder moves, making it very stiff and sore. The shoulder joint becomes inflamed and tightened due to scarring in the joint called fibrosis. It can take years to get better, and for around 50% of individuals the symptoms last even longer. FS causes a profound negative impact on physical and mental health, including disturbed sleep, low mood, difficulty performing everyday activities and, in many cases, are unable to continue working. FS affects around 1 in 10 people, and almost twice as many women as men between the ages of 40-60 years, but it is unknown why. It is thought to either be related to changes in sex hormones during the menopause, or due to the way the body handles sugar and fat, which changes with the menopause. However, associations between the menopause transition and FS are not well established and previous evidence has been poor quality. Current treatments include physiotherapy, a steroid injection or surgery but none of these treat the underlying cause of FS. Women with FS said they would like to know why they developed FS and more early treatment options to avoid a long recovery or an operation.\n\nAim This study aims to understand if there is a link between the menopause, changes in blood sugar levels and FS in women.\n\nPlan In Part 1, women who have had FS will fill in an electronic questionnaire to give us information about their menopause status at the onset of FS, how long their symptoms lasted, what treatments they tried, and if they had any other health conditions. This will enable us to determine the relationship between the menopause and the onset of FS.\n\nIn Part 2, the investigators will invite 18 perimenopausal women with recently diagnosed FS and 18 matched women without FS to attend a one-day visit at the University of Nottingham. The investigators will measure their blood sugar levels over two weeks using a small monitor on their arm. The investigators will assess their menopause symptoms and shoulder related outcomes using validated questionnaires. The investigators will assess their shoulder movement and measure body fat and muscle levels, physical activity levels, diet, and take a blood sample to test sex hormones, inflammation and lipids, as well as markers related to frozen shoulder. This will help us to assess the relationship between blood glucose control and the onset of FS in perimenopausal women.\n\nImpact This research will help us understand if there's a link between menopause, blood sugar control, and FS. It could lead to new clinical trials testing treatments early in FS, such as a glucose lowering medication or hormone therapy, to help women recover faster and avoid surgery. This may improve clinical outcomes in women with FS and reduce costs associated with treating FS. This important question came directly from patients and has not been studied in depth before. The investigators plan to share the results widely through health newsletters, podcasts, research conferences, and medical journals.",[26],[125,232,233],"menopause","glucose","2026-05-17",{"date":236,"type":31},"2026-05-22",{"date":238,"type":20},"2026-08",{"date":240,"type":20},"2027-09",{"name":242,"class":38},"University of Nottingham",{"id":244,"slug":4,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":249,"enrollmentInfo":250,"targetDuration":4,"studyType":21,"phases":252,"briefSummary":253,"conditions":254,"keywords":258,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":39},"100630864","NCT07493213","USG-Guided Shoulder Injections in Frozen Shoulder","Effectiveness of USG-Guided Shoulder Injections as an Adjunct to a Home Exercise Program in the Conservative Management of Painful Frozen Shoulder and Its Association With Pain Phenotypes","Inclusion Criteria:\n\nAge between 18 and 75 years and willingness to participate in the study\n\nPresence of shoulder pain lasting at least 3 months and a diagnosis of primary frozen shoulder\n\nPain intensity ≥ 4\u002F10 on the Visual Analog Scale (VAS), resistant to medical treatment\u002Fanalgesics\n\nRestriction of ≥30 degrees in at least two planes of shoulder motion (flexion, abduction, or external rotation)\n\n\\-\n\nExclusion Criteria:\n\n* History of shoulder trauma\n\nPresence of neurological conditions such as stroke, brachial plexus injury, Parkinson's disease, or cervical spine pathology with or without radiculopathy\n\nHistory of shoulder surgery, shoulder malignancy or tumor, or prior shoulder manipulation\n\nPresence of shoulder arthritis, rotator cuff tear, other shoulder injuries, or thoracic outlet syndrome\n\nSystemic diseases affecting the shoulder, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, labral or articular cartilage injuries), or inflammatory rheumatic diseases\n\nSteroid injection to the affected extremity within the last 3 months, use of oral steroids or NSAIDs, or ongoing surgical\u002Finterventional treatment\n\nPregnancy or lactation\n\nUncontrolled diabetes, heart failure, or uncontrolled systemic diseases (e.g., liver failure, chronic kidney disease, significant endocrine disorders)\n\nCommunication problems or severe psychiatric disorders","75 Years",{"count":251,"type":20},68,[23],"Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life. This study aims to evaluate the effectiveness of USG-guided shoulder injections, when added to a home-based exercise program, in the conservative management of patients with chronic, painful frozen shoulder.\n\nIn this prospective randomized study, patients diagnosed with painful frozen shoulder will be included. In addition to a standardized home-based exercise program, patients will receive either USG-guided suprascapular nerve block alone or a combination of suprascapular nerve block and subacromial injection. The effects of these approaches on clinical outcomes will be assessed over a 20-week follow-up period.\n\nPrimary outcome measures include pain intensity assessed by the Visual Analog Scale (VAS), functional status evaluated by the Shoulder Pain and Disability Index (SPADI), and shoulder range of motion. Secondary outcomes include depression level (Beck Depression Inventory), sleep quality, pain phenotype (nociplastic, neuropathic, or nociceptive), hand grip strength, ultrasonographic findings ( (coracohumeral ligament thickness, subacromial bursa thickness) , and patient satisfaction (subjective impression of improvement).\n\nThe results of this study are expected to provide evidence on the comparative effectiveness and additional benefits of different shoulder injection approaches when combined with home-based exercise therapy in patients with chronic frozen shoulder.",[26,153,255,256,257],"Shoulder Pain","Nociplastic Pain","Neuropathic Pain",[26,153,259,260,255,261,262,263,264,265],"Shoulder Injection","Home Exercise Program","Range of Motion","SPADI","Ultrasound-Guided Injection","pain phenotypes","exercises","2026-05-11",{"date":268,"type":31},"2026-05-14",{"date":270,"type":31},"2026-04-01",{"date":272,"type":20},"2027-06-30",{"name":274,"class":275},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":277,"slug":4,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":249,"enrollmentInfo":282,"targetDuration":4,"studyType":21,"phases":284,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":293,"leadSponsor":295,"locationsCount":39},"100630865","NCT07493226","Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis","Comparative Efficacy of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) With Distinct Chemical Structures in Shoulder Adhesive Capsulitis and the Role of Pain Phenotypes","Inclusion Criteria:\n\n1. Being between 18-75 years of age\n2. Having shoulder pain that has lasted for at least one month and being diagnosed with primary frozen shoulder\n3. Having a VAS pain level ≥ 4\u002F10\n4. Having ≥30 degrees of range of motion restriction in at least two planes (flexion, abduction, or external rotation)\n5. Not having any exclusion criteria and agreeing to participate in the study voluntarily\n\nExclusion Criteria:\n\n1. Patients with a history of shoulder trauma, those with musculoskeletal disorders characterized by pain and loss of function in the affected extremity (such as lateral epicondylitis, flexor tendon injury, de Quervein's tenosynovitis)\n2. Presence of neurological involvement such as stroke, brachial plexus injury, Parkinson's disease, and cervical spine injury with or without radiculopathy\n3. History of shoulder surgery, malignancy or tumor in the shoulder, those who have undergone shoulder manipulation\n4. Presence of shoulder arthritis, rotator cuff tear or other shoulder injuries, thoracic outlet syndrome\n5. Systemic disease affecting the shoulder region, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, history of labrum or articular cartilage injuries), inflammatory rheumatic diseases\n6. Those who have received steroid injections into the affected extremity within the last 3 months, those using oral steroids or NSAIDs, those receiving any surgical or interventional treatment, or Planned individuals:\n7. Those who are pregnant or lactating\n8. Those with uncontrolled diabetes, heart failure, uncontrolled systemic disease (liver disease, chronic kidney failure, significant endocrine disorders, etc.)\n9. Those with communication problems, severe psychiatric disorders\n10. Those allergic to NSAIDs or with any contraindications\n11. Those with bleeding, coagulation disorders, stomach ulcers, or symptomatic gastritis",{"count":283,"type":20},120,[23],"Patients aged 18-75 years who present to a tertiary rehabilitation hospital with shoulder pain and restricted range of motion, and who consent to participate, will be included in the study. Eligibility will be determined based on predefined inclusion and exclusion criteria.\n\nEligible patients will be randomly assigned to receive one of several nonsteroidal anti-inflammatory drugs (NSAIDs) with differing chemical properties (e.g., diclofenac, meloxicam, or indomethacin), in combination with a home-based exercise program for shoulder adhesive capsulitis. Patients' sociodemographic data, as well as detailed clinical and examination findings and baseline outcomes, will be recorded. Patients will be informed about their condition, and modifications to activities of daily living will be recommended.Patients' pain phenotypes (nociceptive, neuropathic, nociplastic) will be categorized based on clinical history and questionnaires, and it will be determined which pain types derive greater benefit from NSAIDs.\n\nFollow-up assessments will be conducted at the end of the first and second weeks. At the first-week follow-up, pain intensity will be evaluated using the Visual Analog Scale (VAS). If the treatment is deemed effective (defined as a ≥3-point reduction or ≥50% decrease in VAS), the same NSAID will be continued for an additional week; otherwise, it will be switched to an alternative NSAID with a different biochemical profile (group). The outcomes assessments will be performed by a blinded evaluator to minimize bias.",[26,153,255,287,256,257],"NSAID (Non-Steroidal Anti-Inflammatory Drug)",[125,289,184,264,265,290],"adhesive capsulitis","Nonsteroidal Anti-Inflammatory Drugs",{"date":268,"type":31},{"date":270,"type":31},{"date":294,"type":20},"2027-03-30",{"name":274,"class":275},{"id":297,"slug":4,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":15,"minAge":201,"maxAge":17,"enrollmentInfo":302,"targetDuration":4,"studyType":21,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":39},"100571866","NCT06725823","Therapeutic Effect of Shoulder Anterior Capsular Block Versus Suprascapular Nerve Block in Patients With Frozen Shoulder","Therapeutic Effect of Shoulder Anterior Capsular Block (SHAC) Versus Suprascapular Nerve Block in Patients With Frozen Shoulder","Inclusion Criteria:\n\n* Age above 18 years.\n\n  * Both sexes, males and females.\n  * History of complaint \\>6 weeks\n  * Restricted shoulder movement unilaterally in at least 2 planes including abduction, external rotation, and internal rotation and restricted passive movement.\n\nExclusion Criteria:\n\n* Patient refusal.\n\n  * -Allergy to local anaesthetics.\n  * -Infection at the site of injection .\n  * -Coagulopathy\n  * -Prolonged opioid medication\n  * -Pregnancy\n  * -Acute trauma, fracture of the shoulder\n  * People who had received an intra-articular shoulder injection within the last 6 months.\n  * Patients with tendon tear",{"count":303,"type":20},50,[23],"he study will include 50 patients with frozen shoulder with no healthy volunteer , Patients in this study will be randomized into two groups suprascapular nerve block and Shoulder anterior capsular block",[26],"2026-04-30",{"date":309,"type":31},"2026-05-06",{"date":311,"type":31},"2025-01-10",{"date":313,"type":20},"2026-07-01",{"name":315,"class":38},"Sohag University",{"id":317,"slug":4,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":321,"targetDuration":4,"studyType":228,"phases":4,"briefSummary":323,"conditions":324,"keywords":325,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":4},"100632211","NCT07510737","The Effect of Cross Training on Clinical and Functional Outcomes in Frozen Shoulder Rehabilitation","Inclusion Criteria:\n\n* Having a diagnosis of unilateral primary or secondary frozen shoulder.\n* Range of motion in external rotation, abduction, or flexion reduced by less than 50% in at least one of these directions compared to the unaffected shoulder.\n* Loss of joint range of motion exceeding 30% in at least two movement planes compared to the unaffected shoulder.\n* Aged between 18 and 65 years.\n\nExclusion Criteria:\n\n* Presence of a concomitant shoulder injury (e.g., rotator cuff tear).\n* Osteoarthritis in both shoulders or in the acromioclavicular joint.\n* Previous treatment for frozen shoulder.\n* Psychiatric disorders that may interfere with adherence to medical or physical therapy.\n* Presence of other neurological disorders.\n* A score below 24 on the Mini-Mental State Examination (MMSE).",{"count":322,"type":20},38,"This randomized controlled, single-blind, quasi-experimental study primarily aims to investigate the effects of unilateral resistance exercise applied without directly loading the affected shoulder on muscle strength and upper extremity function in individuals with frozen shoulder. Additionally, the study seeks to examine the effects on joint range of motion, quality of life, and activities of daily living. The study will be conducted among individuals diagnosed with frozen shoulder at the Physiotherapy and Rehabilitation Outpatient Clinic of Malatya Battalgazi State Hospital. The data collection process is planned to be completed between February 2026 and December 2026.\n\nParticipants will be selected from the relevant population using a non-probability convenience sampling method. Individuals meeting the inclusion criteria will be enrolled after providing written informed consent. The study will be carried out in accordance with the principles of the Declaration of Helsinki. Participants will be randomly assigned to either the control or intervention group.\n\nThe study will include individuals aged 18-65 years with a diagnosis of unilateral primary or secondary frozen shoulder, presenting with more than 50% restriction in at least one of the following shoulder movements compared to the unaffected side: external rotation, abduction, or flexion, and with more than 30% limitation in joint range of motion in at least two movement planes.\n\nIndividuals with concomitant shoulder trauma (e.g., rotator cuff injury), bilateral shoulder involvement, acromioclavicular joint osteoarthritis, prior treatment for frozen shoulder, psychiatric disorders that may affect compliance with medical or physical therapy interventions, concomitant neurological conditions, or a Mini-Mental State Examination (MMSE) score below 24 will be excluded from the study.",[26],[326,327,328,329],"Frozen shoulder","Cross training","Muscle strength","Function","2026-03-30",{"date":332,"type":31},"2026-04-03",{"date":334,"type":20},"2026-03-15",{"date":336,"type":20},"2026-12-25",{"name":338,"class":38},"Inonu University",{"id":340,"slug":4,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":15,"minAge":346,"maxAge":347,"enrollmentInfo":348,"targetDuration":350,"studyType":228,"phases":4,"briefSummary":351,"conditions":352,"keywords":353,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":39},"100631025","NCT07495306","Electrophysiologic Changes After Extended 360° Capsular Release","Electrophysiological Evidence of Neural Function Improvement After Extended Arthroscopic Circumferential Capsular Release for Adhesive Capsulitis","FROZEN-EMG","Inclusion Criteria:\n\n* Age between 21 and 70 years\n* Diagnosis of adhesive capsulitis (frozen shoulder)\n* Persistent symptoms despite conservative treatment (e.g., physical therapy, medication, or intra-articular injections)\n* Planned arthroscopic capsular release surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known peripheral neuropathy\n* Previous brachial plexus injury\n* History of ipsilateral shoulder neurovascular surgery\n* Previous proximal brachial plexus surgery\n* Coagulation disorders\n* Active infection\n* Pregnancy","21 Years","70 Years",{"count":349,"type":20},15,"12 Weeks","Frozen shoulder (adhesive capsulitis) is a condition characterized by shoulder pain and restricted range of motion, significantly impairing daily living activities. In cases that do not respond to conservative treatment, arthroscopic capsular release is an effective surgical treatment option. The 360° capsular release technique, performed by some surgeons, involves release of the inferior capsule and therefore carries a potential risk of nerve injury due to the anatomical proximity of neurovascular structures such as the axillary nerve. In addition, surgical manipulations performed around the coracoid process may exert mechanical or compressive effects on the musculocutaneous nerve and its sensory continuation, the lateral antebrachial cutaneous nerve, due to their close relationship with the lateral cord of the brachial plexus.\n\nThe aim of this prospective, single-center observational clinical study is to objectively evaluate the morphological and functional effects of inferior capsular release and coracoid region dissection performed during arthroscopic 360° capsular release surgery on the axillary and musculocutaneous nerves, using electromyography (EMG) and nerve conduction studies (NCS) in patients with frozen shoulder.\n\nPatients aged 21-70 years with a diagnosis of frozen shoulder who have not responded to conservative treatments and are scheduled for arthroscopic capsular release will be included in the study. EMG and NCS assessments will be performed at the preoperative baseline, and at 12 weeks postoperatively. For the axillary nerve, the deltoid and teres minor muscles will be evaluated; for the musculocutaneous nerve, the biceps brachii and brachialis muscles will be assessed. Additionally, sensory conduction of the lateral antebrachial cutaneous nerve will be examined. Along with electrophysiological findings, shoulder range of motion (ROM), pain (VAS), muscle strength (MRC), and functional scores will also be recorded.\n\nThis study is expected to provide objective evidence regarding the effects of arthroscopic capsular release surgery on peripheral nerve function, thereby contributing new data on the safety of the surgical technique and enriching the currently limited literature on electromyographic evaluation in frozen shoulder surgery.",[153,26],[153,354,355,356,357,358,359],"360° Capsular Release","Shoulder Arthroscopy","Electromyography","Axillary Nerve","Musculocutaneous Nerve","Peripheral Nerve Function","2026-03-23",{"date":362,"type":31},"2026-03-27",{"date":364,"type":31},"2026-02-26",{"date":366,"type":20},"2027-03-14",{"name":368,"class":38},"Acibadem University",{"id":370,"slug":4,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":15,"minAge":374,"maxAge":4,"enrollmentInfo":375,"targetDuration":4,"studyType":21,"phases":377,"briefSummary":378,"conditions":379,"keywords":380,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":39},"100630016","NCT07482189","Effectiveness and Efficiency of an Upper Limb Active-Passive Exoskeleton Robot in Patients With Frozen Shoulder","Inclusion Criteria:\n\n\\-\n\n1\\. Patients aged 20 years or older diagnosed by a clinician with primary or secondary frozen shoulder or adhesive capsulitis:\n\n1. Patients diagnosed by a clinician with frozen shoulder or adhesive capsulitis in the stiff phase.\n2. The patient has a loss of at least 50% of passive joint range of motion (including of shoulder flexion, abduction, internal rotation, and external rotation) on the affected shoulder compared to the relatively healthy shoulder.\n\nExclusion Criteria:\n\n1. Individuals with osteoarthritis or other skeletal conditions of the shoulder joint.\n2. Individuals with any contraindications to treatment, such as joint fusion, severe osteoporosis, or symptoms of any peripheral nerve compression.\n3. Individuals with untreated joint dislocations, fractures, or tendon ruptures.\n4. Individuals who have received steroid injections within the month prior to the study.\n5. Individuals who are uncommunicated or cognitively impaired.\n6. Pregnant women.\n7. Patients who refuse recruitment will also be excluded.","20 Years",{"count":376,"type":20},40,[23],"Frozen shoulder, also known as adhesive capsulitis, is a common chronic shoulder disorder with symptoms including shoulder pain, limitations in both active and passive range of motion, and muscle weakness, which significantly affects daily functional abilities. The investigator applied upper limb exoskeleton-assisted therapy. This experiment used a randomized controlled trial to assess the clinical rehabilitation effects of exoskeleton-assisted range of motion and resistance training on patients with frozen shoulder.",[76,26],[326,381,382,383,384],"Adhesive capsulitis","Exoskeleton robots","Robot-assisted rehabilitation","Rehabilitation","2026-03-21",{"date":387,"type":31},"2026-03-25",{"date":389,"type":20},"2026-03-16",{"date":391,"type":20},"2027-03-15",{"name":393,"class":38},"China Medical University Hospital",{"id":395,"slug":4,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":15,"minAge":374,"maxAge":347,"enrollmentInfo":400,"targetDuration":4,"studyType":21,"phases":401,"briefSummary":402,"conditions":403,"keywords":404,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":413,"locationsCount":39},"100626272","NCT07433478","Cervical and Thoracic Mobility Training in Patients With Adhesive Capsulitis","The Effect of Cervical and Thoracic Mobility Training on Posture, Shoulder Pain, Range of Motion, and Shoulder Functionality in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Diagnosis of unilateral adhesive capsulitis\n* Being between the ages of 20 and 70\n\nExclusion Criteria:\n\n* Presence of glenohumeral joint osteoarthritis, dislocation, subluxation, fracture, tumor\n* Rotator cuff injury\n* Diagnosis of radiculopathy, rheumatological or neurological disease\n* Presence of Thoracic Outlet Syndrome\n* History of surgery on the affected upper extremity\n* Any mental problem that would prevent compliance with tests and exercises",{"count":376,"type":20},[23],"The aim of this study is to investigate the effect of cervical and thoracic mobilization training on posture, shoulder pain, joint range of motion and shoulder function in patients with adhesive capsulitis.",[26],[326,405,406],"Adhesizve capsulitis","mobilization","2026-02-25",{"date":409,"type":31},"2026-02-27",{"date":411,"type":20},"2026-04",{"date":238,"type":20},{"name":414,"class":38},"Zonguldak Bulent Ecevit University",{"id":416,"slug":4,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":225,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":21,"phases":423,"briefSummary":424,"conditions":425,"keywords":427,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":39},"100614097","NCT07275164","HIIT for Inflammatory-driven Shoulder Pain.","Revolutionizing Musculoskeletal Shoulder Pain Management: High-intensity Interval Training as a Systemic Intervention. A Feasibility Study.","Inclusion Criteria:\n\nShoulder pain group\n\n* Shoulder pain \\> 3 months\n* Diagnosis of rotator cuff related shoulder pain or frozen shoulder\n* Understanding Dutch in speaking and writing.\n\nControl group\n\no Understanding Dutch in speaking and writing\n\nExclusion Criteria:\n\nShoulder pain group\n\n* \\\u003C18 years\n* Shoulder surgery or trauma in past year\n* Neurological, cancer, or neuromuscular disease\n* Osteoarthritis, cervical or AC joint pathology\n* Heavy physical exertion \\\u003C48h before testing\n\nControl group\n\n* \\\u003C18 years\n* recent or recurrent neck\u002Fshoulder pain\n* systemic or neurological disease\n* psychiatric disorders\n* pregnancy\u002Fbreastfeeding\n* pain medication \\\u003C48h before test",{"count":422,"type":20},30,[23],"This feasibility study investigates whether high-intensity interval training (HIIT) is feasible and acceptable for individuals with long-term shoulder pain where low-grade inflammation is suspected. Many patients do not recover fully with current local treatments, and systemic factors such as inflammation, and metabolic changes, additionally disturbances in the functioning of the nervous system often seem to play a role. HIIT is a time-efficient form of exercise that has been shown to improve inflammation and metabolic values and positively influence the balance of the nervous system. In this feasibility study, the investigators are enrolling 15 individuals with persistent shoulder pain (diagnosed with rotator cuff-related shoulder pain or frozen shoulder) with \\>3 months of symptoms, and 15 individuals without shoulder complaints. All participants will undergo measurements of inflammatory levels, glycosylated hemoglobin (HbA1c), blood pressure, body composition, pain sensitivity tests, and complete questionnaires about autonomic complaints and quality of life. Participants with shoulder pain will also perform one personalized HIIT session on a cycle ergometer. The investigators will assess whether participants accept a systemic intervention for their shoulder pain, if they are cooperative, and how they feel about the session; additionally, any side effects will be recorded. The aim is to determine whether HIIT is practically feasible and safe for this group and whether there are indications that systemic factors such as inflammation and nervous system function are associated with persistent shoulder pain. The outcome will determine whether follow-up research with a larger study is worthwhile.",[180,426,26,208,255],"Rotator Cuff Related Shoulder Pain",[428,429,430,431,125,432,433],"low-grade inflammation","chronic shoulder pain","autonomic dysfunction","metabolic syndrome","rotator cuff related shoulder pain","high intensity interval training","2026-02-10",{"date":436,"type":31},"2026-02-13",{"date":438,"type":31},"2025-12-10",{"date":440,"type":20},"2026-10",{"name":442,"class":38},"Universiteit Antwerpen",{"id":444,"slug":4,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":15,"minAge":448,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":21,"phases":450,"briefSummary":451,"conditions":452,"keywords":455,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":39},"100622946","NCT07390227","Virtual Reality Intervention in Patients With Persistent Shoulder Pain","Inclusion Criteria:\n\n* General inclusion criteria:\n\n  * Unilateral shoulder pain NPRS ≥ 4\u002F10, persisting longer than 3 months\n  * Adults ≥ 16 years old\n  * Willing and able to comply with study protocol\n  * Diagnosis of rotator cuff related shoulder pain, or shoulder instability, or frozen shoulder, confirmed according to international clinical guidelines\n\n    1\\. RC related shoulder pain\n  * shoulder pain and\u002For weakness during active or resisted shoulder external rotation, and or, shoulder elevation and\u002For\n  * Presence of Painful arc during elevation\n\n    2\\. shoulder instability\n  * Radiographically, computed tomography scans, magnetic resonance imaging scans confirmed dislocation or\n  * Documented history of manual or surgical relocation of the shoulder\n  * Traumatic onset with persistent symptoms\n  * Positive apprehension sign (fear of imminent dislocation when the arm is placed in abduction and external rotation during clinical examination)\n\n    3\\. frozen shoulder\n  * Restricted active and passive range of shoulder movement in all directions\n  * Restricted active and passive shoulder external rotation of 50 percent compared to non-painful arm\n  * Nothing abnormal detected on radiograph of shoulder\n\nExclusion Criteria:\n\n* Neurological disease affecting the shoulder\n* Shoulder stiffness not consistent to frozen shoulder\n* Pain in the shoulder that is elicited by movements of the head and neck.\n* history of motion-sickness\n* history of seizures\n* severe vertigo or vestibular impairment.","16 Years",{"count":422,"type":20},[23],"Shoulder pain is very common and can make daily activities difficult. Many people have shoulder pain for a long time, even after treatment. Common shoulder problems include pain from the shoulder muscles and tendons, a frozen shoulder, or an unstable shoulder. Unfortunately, both surgery and physiotherapy often help only a little. This can be due to many reasons, such as people not continuing their exercises, fear of moving the shoulder, incorrect beliefs about pain, other health problems, or lifestyle factors.\n\nVirtual Reality (VR) is a new and promising technology that is already being used to help people with long-lasting pain. By using a VR headset, people can exercise in a motivating and engaging virtual environment. VR may help reduce fear of movement, improve how people feel about their body, make movement easier, and help people stick to their exercises. However, there is still very little research on using VR for long-lasting shoulder pain.\n\nThe goal of this study is to find out whether a home-based VR exercise program for people with ongoing shoulder complaints is practical and acceptable. The investigators want to know if people are willing and able to use VR at home, whether they continue the treatment, and whether it shows early signs of reducing pain and limitations. They also want to understand who benefits most from VR, in which situations it works best, and why it may or may not help.\n\nPeople aged 16 years and older who have had shoulder pain and limitations for more than three months can take part. This includes people with shoulder tendon-related pain, frozen shoulder, or shoulder instability.\n\nThe study lasts six weeks and includes three parts. First, participants receive online educational videos about shoulder pain and movement. Second, they take part in three physiotherapy sessions: one in person and two online. Third, participants use a VR headset at home every day for about 15 minutes to perform guided shoulder and whole-body exercises, such as reaching or aiming tasks. The exercises gradually become more challenging. Participants receive clear written and video instructions, and technical support is available if needed.\n\nDuring the study, participants will complete questionnaires and the VR system will record basic usage data. At the end of the study, group interviews will be held with participants and physiotherapists to talk about their experiences with VR and how it influenced pain, movement, and daily activities.\n\nUsing VR is considered safe. Some people may experience mild and short-lasting side effects, such as dizziness, but serious problems are not expected. The main effort for participants is the time spent on exercises and completing questionnaires.\n\nThe results of this study will help determine whether VR is a useful and realistic treatment option for people with long-lasting shoulder pain and will guide future, larger studies.",[453,454,26],"Rotator Cuff Syndrome","Shoulder Instability",[456,457,458],"Virtual reality","Shoulder","persitent shoulder pain","2026-02-05",{"date":461,"type":31},"2026-02-09",{"date":463,"type":20},"2026-01-12",{"date":465,"type":20},"2026-12-01",{"name":467,"class":38},"HAN University of Applied Sciences",{"id":469,"slug":4,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":11,"sex":15,"minAge":46,"maxAge":17,"enrollmentInfo":474,"targetDuration":4,"studyType":21,"phases":475,"briefSummary":476,"conditions":477,"keywords":478,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":485,"leadSponsor":487,"locationsCount":39},"100621294","NCT07368751","Vagus Nerve Stimulation Effect in Frozen Shoulder Treatment","Clinical Effects of Transcutaneous Vagus Nerve Stimulation in the Treatment of Frozen Shoulder: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 40 and 65 years.\n* Less than 50% range of motion compared with the contralateral shoulder in at least one movement (external rotation, abduction, flexion, or internal rotation).\n* More than 25% loss of range of motion in at least two movement planes compared with the unaffected shoulder.\n* Increasing limitation of glenohumeral external and internal rotation during abduction from 45° to 90°.\n* Shoulder pain lasting at least 3 months during activities of daily living.\n\nExclusion Criteria:\n\n* Passive joint range of motion within normal limits\n* External rotation range of motion \\\u003C30°\n* Radiographic evidence of glenohumeral arthritis\n* Presence of inflammatory joint disease\n* Previous treatment related to the current shoulder complaint (physiotherapy and rehabilitation, intra-articular injection, or surgery)\n* Pain intensity \\\u003C3 according to the Numerical Pain Rating Scale (NPRS)\n* Presence of neurological deficits, cardiac disease, neuropathic disorders, or pregnancy",{"count":376,"type":20},[23],"The goal of this clinical trial is to learn if the addition of transcutaneous vagus nerve stimulation (tVNS) to exercise is effective in improving pain, shoulder function, shoulder range of motion, and psychological factors in adults with frozen shoulder.\n\nThe main questions this study aims to answer are:\n\nDoes adding tVNS to exercise reduce shoulder pain ? Does adding tVNS to exercise improve shoulder function and shoulder range of motion? Does adding tVNS to exercise improve psychological factors ? Does adding tVNS to exercise improve patient satisfaction?\n\nResearchers will compare the effect of active tVNS added to exercise with sham-controlled tVNS added to exercise to determine whether adding tVNS provides additional benefits in the management of frozen shoulder.\n\nParticipants will:\n\nReceive active tVNS plus exercise therapy or sham-controlled tVNS plus exercise therapy.\n\nAttend supervised rehabilitation sessions 3 times per week for 6 weeks. Perform a home exercise program as instructed by the study physiotherapist.",[26],[26,479,480],"Vagus Nerve Stimulation","Exercise","2026-02-02",{"date":483,"type":31},"2026-02-04",{"date":481,"type":31},{"date":486,"type":20},"2027-03-01",{"name":488,"class":38},"Istanbul University - Cerrahpasa",{"id":490,"slug":4,"hasResults":11,"nctId":491,"briefTitle":492,"officialTitle":492,"acronym":4,"eligibilityCriteria":493,"healthyVolunteers":11,"sex":15,"minAge":494,"maxAge":47,"enrollmentInfo":495,"targetDuration":4,"studyType":21,"phases":496,"briefSummary":497,"conditions":498,"keywords":501,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":39},"100620386","NCT07356947","The Combined Effect of Mulligan Technique and Scapular Mobilization in Shoulder Adhesive Capsulitis","Inclusion Criteria:\n\n* Medically stable and willing to provide informed consent to participate in the study.\n* Age between 30 and 60 years.\n* Both male and female participants.\n* Unilateral shoulder involvement with pain and limited active and passive range of motion in lateral rotation, abduction, and internal rotation for more than three months compared with the unaffected side.\n* Clinically diagnosed with adhesive capsulitis (frozen shoulder).\n\nExclusion Criteria:\n\n* History of shoulder surgery.\n* History of radiotherapy or chemotherapy.\n* Presence of acute infection in the area to be treated.\n* History of skin disease.\n* History of cervical radiculopathy within the past six months.\n* Secondary adhesive capsulitis, rotator cuff tears, shoulder fractures, or dislocations.","30 Years",{"count":322,"type":20},[23],"The shoulder joint capsule is a fibrous sheath that encloses and stabilizes the structures of the shoulder joint, extending from the anatomical neck of the humerus to the rim of the glenoid fossa. It is normally lax, allowing a wide range of motion. Shoulder adhesive capsulitis, or frozen shoulder, is a common musculoskeletal condition characterized by pain and restricted movement due to thickening and contraction of this capsule. Proper coordination between the scapula and humerus-known as the scapulohumeral rhythm-is essential for normal shoulder motion. Disruption of this rhythm contributes to movement limitation and pain in adhesive capsulitis.\n\nThis randomized, single-blind clinical trial aims to investigate the combined effect of the Mulligan technique and scapular mobilization on improving shoulder range of motion, pain, disability, and scapulohumeral rhythm in patients with adhesive capsulitis. Thirty-eight participants aged 30 to 60 years, diagnosed with unilateral adhesive capsulitis, will be randomly assigned to two groups. Group A will receive Mulligan mobilization techniques for shoulder elevation, internal and external rotation, along with scapular mobilization. Group B will receive conventional physical therapy consisting of hot packs, ultrasound, stretching, and range-of-motion exercises. Both groups will undergo treatment three times per week for four weeks.\n\nPrimary outcomes include changes in shoulder range of motion (measured using a digital goniometer), pain and disability (measured by the Shoulder Pain and Disability Index \\[SPADI\\]), and scapulohumeral rhythm (assessed using tape measurement). The study is expected to provide clinical evidence on whether combining Mulligan and scapular mobilization techniques yields superior functional recovery compared with conventional physiotherapy alone in patients with shoulder adhesive capsulitis.",[499,26,500],"Adhesive Capsulitis of Shoulder","Shoulder Pain and Stiffness",[153,26,502,255,503,504,505,506],"Shoulder Joint","Scapulohumeral Rhythm","Mulligan Technique","Mobilization with Movement","Scapular Mobilization","2026-01-27",{"date":509,"type":31},"2026-01-28",{"date":511,"type":20},"2026-02",{"date":513,"type":20},"2027-08",{"name":515,"class":38},"Deraya University",{"id":517,"slug":4,"hasResults":11,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":521,"eligibilityCriteria":522,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":523,"targetDuration":4,"studyType":21,"phases":524,"briefSummary":525,"conditions":526,"keywords":530,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":39},"100622166","NCT07380087","Suprascapular Nerve Block to Improve Tolerance and Outcomes of Shoulder Hydrodistension in Adhesive Capsulitis","Efficacy of Suprascapular Nerve Block on the Tolerability and Effectiveness of Shoulder Hydrodistension in Patients With Adhesive Capsulitis: A Randomized Clinical Trial","SHINE","Inclusion Criteria\n\n* Adults aged 18 years or older\n* Clinical diagnosis of adhesive capsulitis of the shoulder\n* Persistent pain and functional limitation despite initial conservative treatment\n* Ability to understand study procedures\n* Ability to provide written informed consent\n\nExclusion Criteria\n\n* Known allergy or hypersensitivity to ropivacaine or methylprednisolone\n* Active infection (local or systemic)\n* Uncontrolled coagulopathy or ongoing therapeutic anticoagulation\n* Recent surgery of the affected shoulder\n* Neurological disease affecting the upper limb\n* Pregnancy",{"count":303,"type":20},[23],"Adhesive capsulitis (\"frozen shoulder\") causes significant pain and loss of shoulder mobility. Shoulder hydrodistension is an established treatment that can improve movement and reduce symptoms, but the procedure itself may be painful and difficult for some patients to tolerate.\n\nThis randomized clinical trial will evaluate whether performing a suprascapular nerve block with local anesthetic immediately before hydrodistension can reduce pain during the procedure, improve patient comfort, and potentially enhance clinical outcomes.\n\nParticipants will be randomly assigned to one of two groups:\n\nhydrodistension alone, or\n\nsuprascapular nerve block followed by hydrodistension.\n\nPain, shoulder mobility, functional ability, psychological measures, and quality of life will be assessed at baseline, 1 month, and 3 months after the procedure. The study aims to determine whether adding a suprascapular nerve block provides better tolerability and improved recovery for patients with adhesive capsulitis.",[153,527,528,26,255,529],"Adhesive Capsulitis of Unspecified Shoulder","Adhesive Capsulitis, Shoulder","Shoulder Stiffness",[531,532,255,533,534,535,384],"Shoulder Hydrodistension","Suprascapular Nerve Block","Shoulder Mobility","Randomized Clinical Trial","Pain Management","2026-01-26",{"date":481,"type":31},{"date":539,"type":20},"2026-03-01",{"date":541,"type":20},"2028-07-31",{"name":543,"class":38},"Universidade do Porto",{"id":545,"slug":4,"hasResults":11,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":11,"sex":15,"minAge":374,"maxAge":550,"enrollmentInfo":551,"targetDuration":4,"studyType":21,"phases":553,"briefSummary":554,"conditions":555,"keywords":559,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":571,"locationsCount":39},"100553873","NCT06491745","Is Adding Extracorporeal Shock Wave Therapy to Physiotherapy and Corticosteroid Injection Beneficial for Frozen Shoulder","Is Adding Extracorporeal Shock Wave Therapy to Physiotherapy and Corticosteroid Injection Beneficial for Frozen Shoulder?","Inclusion Criteria:\n\n1. age between 20 to 80 years old;\n2. shoulder pain for ≥ 1 month;\n3. \\> 30% loss of passive range of motion (ROM) of the affected shoulder in external rotation and\u002For abduction, comparing with the sound side;\n4. pain visual analog scale on maximal passive external rotation or abduction \\> 4;\n5. showing willing to receive ESWT, shoulder joint injection, and attend regular physical therapy programs for 8 weeks.\n\nExclusion Criteria:\n\n1. severe systemic disorders including cancer, stroke, or cardiopulmonary diseases;\n2. uncontrolled DM;\n3. rotator cuff tear or calcification of the affected shoulder;\n4. fracture, dislocation, or arthritis of the shoulder due to rheumatic disorders;\n5. a history of drug allergy to local anesthetics or corticosteroids;\n6. pregnancy;\n7. receiving ESWT, corticosteroid joint or bursa injection of the affected shoulder during the preceding three months","80 Years",{"count":552,"type":20},94,[23],"Frozen shoulder, or adhesive capsulitis of the shoulder, is a common clinical problem characterized by pain, loss of both passive and active range of motion (ROM) of glenohumeral joint (GHJ), leads to functional limitation, and reduces quality of life. Primary frozen shoulder occurs without any obvious connection to any other condition, and secondary frozen shoulder is related to some medical problems, such as an injury, inflammatory, immunological, and endocrine conditions, or surgery of the shoulder. The prevalence of frozen shoulder is 2%-5% in general population, usually between 40 to 60 years old, and more in female. Diabetes patients have more chance of developing frozen shoulder than general population and the prevalence was 13.4%.\n\nFrozen shoulder is clinically divided into 3 overlapping phases. The painful freezing phase has a duration of 10 to 36 weeks and is characterized by pain and stiffness around the shoulder, which may worsen at night. The frozen phase is characterized by restricted ROM with a gradual relief of pain, which occurs at 4 to 12 months. The thawing phase with spontaneous improvement in the ROM takes 12 to 42 months. .Although frozen shoulder is a self-limited condition, the recovery may be slow and incomplete.\n\nTreatment of frozen shoulder consists of physiotherapy, oral medication (nonsteroidal anti-inflammatory drugs or corticosteroid), intra-articular corticosteroid injection, hydrodilatation, suprascapular nerve block, mobilization, manipulation under anesthesia, and operative intervention (arthroscopic release or open release). Because of the uncertainty of the efficacy and risk of surgical treatment, nonsurgical treatments are more likely chosen by patients. Among them, intra-articular steroid injection and physical therapy are commonly used nonsurgical treatments and have shown some benefits. .Because the clinical picture of frozen shoulder may be similar to, or combining with chronic subacromial bursitis, especially in the freezing stage, concomitant subacromial\u002Fsubdeltoid (SASD) bursa injection may be needed for treatment of frozen shoulder. In addition, the 3 stages of frozen shoulder often overlap and the clinical symptoms of patients are complex, adjuvant therapy is often needed throughout the course of treatment. Even after physical therapy (PT) and corticosteroid injection, mild to moderate contracture, especially external rotation, abduction, and internal rotation may still be present.\n\nOver the past few years new evidence has emerged on the effectiveness of extracorporeal shock wave therapy (ESWT) in the treatment of many musculoskeletal disorders. Briefly, ESWT has been shown to promote neovasculization, amplify growth factor and protein synthesis, increase of pain inhibiting substance, alteration of pain receptor neurotransmission, and intensification of tissue regeneration. Furthermore, ESWT can produce a cavitation effect between tissues, cause intertissue release, promote the separation of adhesion, and release the adhesive tissue. Because of its analgesic, anti-fibrotic, and anti-inflammatory effect, application of ESWT as main treatment or an adjunct to other interventions has been tried. Knoblock et al found that focused ESWT can reduce pain in painful nodules in Dupuytren's disease; in a randomized controlled trial Chen et al showed focused ESWT was superior to oral corticosteroid for frozen shoulder, although oral corticosteroid is not commonly prescribed for patients with frozen shoulder. Vahdatpour compared ESWT with sham ESWT on treatment of frozen shoulder after 40mg triamcinolone intra-articular injection, and found that ESWT group seemed to have positive effects on treatment, and quicker return to daily life. Another two studies investigating application of radial shock wave to patients with frozen shoulder showed improvement of ROM, even for diabetic patients. A systemic review and meta-analysis also showed ESWT seems beneficial to patients with frozen shoulder and could be used as an adjunct therapy to routine treatments. However, the authors mentioned that the quality of the included randomized controlled trials were hampered by significant heterogeneity regarding long-term analgesia and joint ROM.\n\nBecause the effect of ESWT against frozen shoulder has not been well established, we aim to investigate whether adding ESWT to corticosteroid injection and routine PT beneficial for patients with frozen shoulder? We hypothesize that ESWT would be a positive adjunctive therapy in the treatment of frozen shoulder.",[26,556,557,558,384],"Corticosteroid Injection","Physical Therapy","Extracorporeal Shock Wave Therapy",[326,560,561,562,563],"corticosteroid injection","physical therapy","extracorporeal shock wave therapy","rehabilitation","2025-12-22",{"date":566,"type":31},"2025-12-30",{"date":568,"type":31},"2024-08-01",{"date":570,"type":20},"2028-12-31",{"name":572,"class":38},"Shin Kong Wu Ho-Su Memorial Hospital",{"id":574,"slug":4,"hasResults":11,"nctId":575,"briefTitle":576,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":225,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":578,"targetDuration":4,"studyType":21,"phases":580,"briefSummary":581,"conditions":582,"keywords":584,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":39},"100230929","NCT02283996","Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment","Inclusion Criteria:\n\n* Patient must be 18 years or older\n* Must meet the following definition for adhesive capsulitis as defined by the American Academy of Orthopedic Surgeons: Self-limiting condition resulting from any inflammatory process about the shoulder in which capsular scar tissue is produced, resulting in pain and limited range of motion; also called frozen shoulder\n* Must be amenable to randomization into either cohort\n\nExclusion Criteria:\n\n* Non-English speaking patients\n* Pregnant women (women of childbearing potential will be advised to undergo regular pregnancy testing)\n* Patients who had previously undergone operative therapy for the condition",{"count":579,"type":20},260,[73],"The purpose of this study is to identify individuals 18 or older who have diagnostic presentation of adhesive capsulitis and randomize them into two arms, distinguished by use of physical therapy and steroid injections compared with steroid injections followed by watchful waiting. This prospective study will be used to determine whether there is a significant impact on patient outcome and whether the additional financial burden is justified. There are no experimental interventions for this study. The use of physical therapy, oral and parenteral corticosteroids, and watchful waiting are offered following the standard of care for adhesive capsulitis. Our hypothesis is that patients will not have a significant difference in outcome between the two study arms. One group will undergo regular physical therapy with corticosteroid injections (Arm 1) and the other will have steroid injections during the inflammatory phase only and then be regularly observed (Arm 2). We also hypothesize there will be a significant financial burden associated with the PT arm that is not justified with the possibility of increased symptom reports in that arm.",[153,26,583],"Shoulder Frozen",[153,26,583,557,585,586,587,588,589],"Corticosteroid Injections","Hydrodilation, Hydro-dilation","Watchful Waiting","Prospective","Glenohumeral Ligament","2025-10-24",{"date":592,"type":31},"2025-10-27",{"date":594,"type":31},"2014-11",{"date":596,"type":20},"2027-12",{"name":598,"class":38},"Massachusetts General Hospital",{"id":600,"slug":4,"hasResults":11,"nctId":601,"briefTitle":602,"officialTitle":603,"acronym":4,"eligibilityCriteria":604,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":605,"targetDuration":4,"studyType":21,"phases":606,"briefSummary":607,"conditions":608,"keywords":609,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":618,"locationsCount":4},"100605369","NCT07161622","Comparing Low-Level Laser and Muscle Energy Techniques in Diabetic Frozen Shoulder","Effects of Low Level Laser Therapy Versus Muscle Energy Techniques Among Diabetic Patients With Frozen Shoulder","Inclusion Criteria:\n\n* Eligible participants were male and female individuals aged 18 to 65 years with a verified diagnosis of type 2 diabetes mellitus and clinical manifestations of frozen shoulder for at least three months. The diagnosis was determined by limited glenohumeral joint mobility, characterised by a decrease of ≥20° in a minimum of three active movements: flexion \\<144°, abduction \\<120°, and external rotation \\<72°. Cases of both unilateral and bilateral nature were incorporated.\n\nExclusion Criteria:\n\n* The exclusion criteria included a history of traumatic shoulder injury or prior surgery; neurological involvement, such as brachial plexus injury or cervical radiculopathy; rotator cuff tears or other ligamentous pathologies; tumours or malignancies affecting the shoulder; and corticosteroid injection within the preceding three months",{"count":19,"type":20},[23],"The current study is to evaluate the comparative effects of low-level laser therapy and muscle energy technique on pain, range of motion, and functional results in diabetic patients with frozen shoulder. This research aims to enhance the existing data on managing diabetes-related musculoskeletal issues by assessing the comparative advantages of various therapies, therefore assisting physicians in choosing appropriate, patient-centred rehabilitation procedures.",[26],[326,610,611,261,612],"Low-Level Laser Therapy","Muscle Energy Technique,","Diabetes","2025-09-17",{"date":213,"type":31},{"date":616,"type":20},"2025-10",{"date":511,"type":20},{"name":619,"class":38},"University of Lahore",{"id":621,"slug":4,"hasResults":11,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":11,"sex":15,"minAge":626,"maxAge":17,"enrollmentInfo":627,"targetDuration":4,"studyType":21,"phases":628,"briefSummary":629,"conditions":630,"keywords":631,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":39},"100599097","NCT07080060","Comparison of Niel-Asher and Spencer Techniques in Frozen Shoulder Patients","Effects of Niel-Asher Technique Versus Spencer Technique Along With Conventional Therapy on Pain, Range of Motion, and Functional Status in Frozen Shoulder Patients","Inclusion Criteria:\n\n* Age group between 35-65 years diagnosed with primary Adhesive Capsulitis.\n* Both gender male and female.\n* Both Active and passive Range of Motion is limited.\n* Stage II Frozen Shoulder patients (Freezing Stage,3-9 months).\n* More than 50% of range of motion is limited in Flexion, Abduction and External rotation as compared to unaffected side.\n* Pain reported on VAS score \\\u003C7\u002F10 in shoulder region.\n* Patients agree to sign written consent form.\n\nExclusion Criteria:\n\n* Patients with systemic illness:\n* Diabetes Mellitus, Thyroid disorders.\n* Rheumatoid Arthritis, Malignancy.\n* Patients with mechanical injuries like:\n* Rotator Cuff injury, Ligamentous Injuries.23\n* Previous Surgery or Manipulation under Anesthesia.\n* Patients with Stage I, III, IV of Frozen Shoulder.\n* Patient reported with VAS score \\>7\u002F10 in shoulder region.","35 Years",{"count":204,"type":20},[23],"This study aims to compare the effectiveness of two manual therapy techniques-Niel-Asher Technique and Spencer Technique-when combined with conventional physiotherapy in treating patients with frozen shoulder (adhesive capsulitis). Frozen shoulder is a painful condition that limits movement and function of the shoulder joint. The study will include 44 adults aged 35 to 65 years who have been diagnosed with stage II frozen shoulder. Participants will be randomly assigned to one of two groups. Both groups will receive standard physiotherapy, including heat therapy, TENS, and stretching exercises. In addition, one group will receive the Niel-Asher Technique, while the other group will receive the Spencer Technique. Pain, range of motion, and shoulder function will be measured before and after a 4-week treatment period using validated tools such as the Visual Analogue Scale (VAS), a goniometer, and the Shoulder Pain and Disability Index (SPADI). The goal is to determine which manual therapy technique is more effective in improving symptoms and function in patients with frozen shoulder.",[26,153],[632,633,634,635,636],"Manual Therapy","Niel-Asher Technique","Spencer Technique","Pain","Range of motion","2025-07-14",{"date":639,"type":31},"2025-07-23",{"date":641,"type":20},"2025-07",{"date":643,"type":20},"2025-11-30",{"name":62,"class":38},""]