Lymphedema Breast Cancer

8

Review clinical trials related to Lymphedema Breast Cancer. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy

Lymphedema is a chronic, progressive, and debilitating condition that occurs with disruption or obstruction of the lymphatic system, which commonly occurs a result of breast cancer therapy. The purpose of this study is to determine if the use of a low risk lymphatic reconstruction procedure at the time of axillary lymph node dissection will reduce the risk of developing lymphedema. Additionally, to determine if this procedure improves objective outcomes of lymphedema and patient quality of life

Participants needed: 80
Trial details
Age: 18-75Biological sex: FemaleType: InterventionalSponsor: Stanford UniversityUpdated: Jun 23, 2026Locations: 1
Eligibility criteria

Ages 18 to 75 years (inclusive) [+6]

Primary lymphedema of the affected upper limb [+17]

Status: Recruiting

The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) 15 months after randomization (and therefore about one year after surgery) compared to conservative treatment only for patients with chronic lymphedema (LE)

Participants needed: 280
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University Hospital, Basel, SwitzerlandUpdated: Jun 4, 2026Locations: 36
Eligibility criteria

Written informed consent. [+6]

No indication for lymphatic surgery according to clinical judgment of the treati... [+2]

Status: Recruiting

Gentle Touch for Post-Mastectomy Lymphedema

This is a single-blind, parallel-group Randomized Controlled Trial (RCT) comparing the efficacy of a specialized manual technique, Gentle Touch (GT), versus a control intervention, both added to the usual rehabilitative care. The study investigates 36 women aged 30 to 75 with Breast Cancer-Related Lymphedema (BCRL). The primary objective is to evaluate the reduction of lymphedema volume in the upper limb. Secondary objectives include assessing the improvement in patients' quality of life and the potential reduction in care burden and costs. The treatment protocol involves 10 bi-weekly sessions over 5 weeks.

Participants needed: 36
Trial details
Phase: Phase 4Age: 30-75Biological sex: FemaleType: InterventionalSponsor: I.R.C.C.S. Fondazione Santa LuciaUpdated: Dec 2, 2025Locations: 2
Eligibility criteria

Gender: Women. [+3]

Concurrent Diseases: Concomitant diseases that may interfere with the study.

Status: Not yet recruiting

Complete Decongestive Therapy Versus Non-pneumatic Compression Therapy in Post Mastectomy Lymphedema

The aim of the study is to compare the effectiveness of Complete Decongestive Therapy and Non-Pneumatic Compression Therapy, both combined with routine physical therapy, in reducing pain and edema volume, improving range of motion, respiratory function, inflammatory markers, and overall quality of life in patients with post-mastectomy lymphedema.

Participants needed: 52
Trial details
Age: 30-60Biological sex: FemaleType: InterventionalSponsor: Lahore University of Biological and Applied SciencesUpdated: Oct 15, 2025Locations: 1
Eligibility criteria

Females with age between 30 to 60 years. (Monticciolo et al., 2021) [+3]

Systemic disorders that might contraindicate the use of sequential compression t... [+8]

Status: Not yet recruiting

Effectiveness of a Therapeutic Exercise Program With Specific Upper Limb Exercises to Reduce Lymphedema and Neuropathy in Breast Cancer Patients: A Pre-post Study (LYNMA)

This study aims to evaluate the effectiveness of a therapeutic exercise program designed specifically for women with breast cancer. The program includes general exercises along with specific movements for the upper limb to help reduce common side effects of cancer treatment such as lymphedema (swelling of the arm) and neuropathy (nerve pain or numbness). Participants will undergo the exercise program and be assessed before and after to determine improvements in their symptoms and overall quality of life. The goal is to provide evidence that targeted physical therapy can improve recovery and well-being in breast cancer survivors.

Participants needed: 30
Trial details
Age: 35-70Biological sex: FemaleType: InterventionalSponsor: Universitat Internacional de CatalunyaUpdated: Sep 18, 2025
Eligibility criteria

Patients receiving treatment for breast carcinoma.reatments include surgical pro... [+3]

Lack of medical authorization. [+3]

Status: Recruiting

LymphoVenous Anastomosis to Prevent Breast Cancer Related Lymphedema

Lymphedema is defined as a chronic condition, caused by lymphostasis. A major part in the Western world consists of iatrogenic lymphedema caused by surgery to the lymph nodes of the axilla or groin. Prophylactic lymphovenous anastomosis (LVA) could be beneficial in the prevention of lymphedema of the extremities.

Participants needed: 80
Trial details
Age: 18-99Biological sex: FemaleType: InterventionalSponsor: University Hospital, GhentUpdated: Nov 8, 2024Locations: 1
Eligibility criteria

lymph node + breast cancer requiring dissection

previous lymphedema [+1]

Status: Recruiting

The Robot-LVA Study: Robot-assisted Microsurgical Lymphaticovenous Anastomosis in Breast Cancer-related Lymphedema

This study assesses the performance of robot-assisted microsurgery. Lymphaticovenous anastomosis (LVA) is the most difficult procedure in microsurgery at this moment. The LVA technique is applied to treat for example breast cancer-related lymphedema (BCRL). Therefore, this LVA procedure is compared using a manual expert and the same expert applying robot-assisted LVA.

Participants needed: 60
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Maastricht University Medical CenterUpdated: Aug 1, 2024Locations: 1
Eligibility criteria

Female gender; [+4]

Male gender; [+7]

Status: Recruiting

A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery

To evaluate the Dayspring Active Wearable Compression Technology in enhancing lymph movement and its safety and effectiveness after lymphatic surgery

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Koya Medical, Inc.Updated: May 20, 2021Locations: 1
Eligibility criteria

Males and females ≥ 18 years of age [+3]

Individuals with a history or presence of a systemic disorder or condition that... [+16]