Health Trials

Major Depression Severe

2

Review clinical trials related to Major Depression Severe. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Shortened LSD Intervention for Major Depressive Disorder

The purpose of this study is to determine the safety and clinical effectiveness of a shortened lysergic acid diethylamide (LSD) experience. This will be achieved by administering the drug risperidone 45-minutes after the administration of LSD.

Participants needed: 10
Trial details
Phase: Phase 1Age: 21-70Biological sex: AllType: InterventionalSponsor: Johns Hopkins UniversityUpdated: Apr 3, 2026Locations: 1
Eligibility criteria

Have given written informed consent [+3]

Women who are pregnant, nursing, or not practicing an effective means of birth c... [+16]

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Status: Not yet recruiting

Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling

The goal of this randomized clinical trial is to be adequately powered to evaluate the effect of ketogenic metabolic therapy on the quality of life in serious mental illness, schizophrenia, bipolar disorder, major depressive disorder.

Participants needed: 120
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Stanford UniversityUpdated: May 16, 2025Locations: 1
Eligibility criteria

diagnosed with bipolar disorder (BD), major depressive disorder (MDD), and or sc... [+14]

has started the ketogenic diet or was in ketosis within 3 months of wanting to e... [+20]

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