[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilation-in-neonates\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilation-in-neonates":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100467831",false,"NCT05371886","Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care","Inclusion Criteria:\n\n* Neonates \\\u003C 45 weeks of corrected gestational age\n* Hospitalized in a Neonatal Intensive Care Unit\n* Undergoing mechanical ventilation\n* Patients that receive morphine alone or morphine and midazolam as continuous infusion\n* Affiliated to a social security system\n\nExclusion Criteria:\n\n* Current weight \\\u003C 600g\n* Neonates under palliative care\n* Therapeutic hypothermia for perinatal anoxia\n* Neonates who underwent a surgical procedure during the past 72 hours\n* Neonates receiving concomitantly a paralytic or another drug for sedation or analgesia other than morphine or midazolam (except for paracetamol\u002Facetaminophen)\n* Parents refusing that their child participate","ALL","20 Weeks","45 Weeks",{"count":18,"type":19},180,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical ventilation, through PKPD modelling.",[25,26],"Sedation Complication","Mechanical Ventilation in Neonates",[28,29,30,31,32],"morphine, midazolam","pharmacokinetics","pharmacodynamics","analgesia","neonates","RECRUITING","2025-11-14",{"date":36,"type":37},"2025-11-17","ACTUAL",{"date":39,"type":37},"2023-04-01",{"date":41,"type":19},"2027-05-01",{"name":43,"class":44},"Centre Hospitalier Intercommunal Creteil","OTHER",5,""]