[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-hypotrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-hypotrophy":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100624481",false,"NCT07410195","Resistance Training Adaptations and Caffeine Intake","Study of Different Caffeine Supplementation Strategies on Resistance Training-Induced Adaptations","Inclusion Criteria:\n\n* Male sex and age between 18-30 years\n* No history of caffeine use or very low habitual intake (\\\u003C50 mg\u002Fday)\n* No participation in a regular resistance training program in the past 6 months\n* Body mass index (BMI) between 18.5-30 kg\u002Fm2\n* Willingness to attend all training and testing sessions regularly\n* Provision of written informed consent after being fully informed about the study\n\nExclusion Criteria:\n\n* Presence of cardiovascular, metabolic, renal, hepatic, or other serious chronic diseases\n* Diagnosed psychiatric disorders or severe caffeine intolerance\u002Fallergy\n* Use of medications affecting caffeine metabolism or muscle anabolism (e.g., beta-blockers, antidepressants, anabolic steroids)\n* Musculoskeletal injuries that prevent safe resistance training\n* Smoking or alcohol consumption at levels that could affect study outcomes\n* Concurrent participation in another exercise intervention study\n* Inability to tolerate DXA scanning, blood sampling, or D2O ingestion procedures",true,"MALE","18 Years","30 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, double-blind, placebo-controlled crossover trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 180 caffeine-naive, inactive young adult males. Participants will undergo two 4-week supervised resistance training programs separated by a 2-week washout\u002Fcrossover period. The three caffeine strategies are: (1) constant daily low-moderate dosing (3 mg\u002Fkg\u002Fday), (2) gradually escalating dose (3 to 6 mg\u002Fkg across weeks), and (3) training-day-only caffeine (3 mg\u002Fkg\u002Fday). Primary outcomes include non-invasive measures of integrated anabolism and hypertrophy (D2O-derived plasma proteomic fractional synthesis rate, DXA muscle volume) and strength metrics. Secondary outcomes include hormonal responses (insulin, cortisol, testosterone, IGF-1), sleep\u002Frecovery parameters, and adverse effects.",[27,28,29,30],"Muscle Hypotrophy","Exercise Performance","Muscle Strength","Adaptation",[32,33,34,35,36,37],"Caffeine","Resistance Training","Muscle Adaptation","Supplementation","Strength Training","Hypertrophy","NOT_YET_RECRUITING","2026-02-07",{"date":41,"type":42},"2026-02-13","ACTUAL",{"date":44,"type":21},"2026-02-20",{"date":46,"type":21},"2026-04-20",{"name":48,"class":49},"Istanbul University - Cerrahpasa","OTHER",""]