[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myocardial-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myocardial-dysfunction":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100431557",false,"NCT04899635","POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium","Profiling Biomechanical Responses and Workload of the Human Myocardium to Explore the Concept of Myocardial Fatigue and Reversibility","POWER","Inclusion Criteria:\n\n* All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study\n* Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative\n\nExclusion Criteria:\n\nThis criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital.\n\n* Patients who do not have the mental capacity to undergo the consent process\n* For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).","ALL","18 Years","85 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.",[25,26,27,28],"Heart Failure","Fatigue; Muscle, Heart","Myocardial Dysfunction","Exhaustion; Heart",[30,31,32,33,34,35],"Myocardial Fatigue","Preload","Afterload","Cardiac Work-loop","Cardiomyocytes","Biomechanical model","RECRUITING","2024-06-17",{"date":39,"type":40},"2024-06-18","ACTUAL",{"date":42,"type":40},"2021-08-03",{"date":44,"type":21},"2025-04-30",{"name":46,"class":47},"University Hospitals Coventry and Warwickshire NHS Trust","OTHER",""]