[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurologically-unimpaired-elderly-participants\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurologically-unimpaired-elderly-participants":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100570006",false,"NCT06701630","Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.","Functional and Behavioural Scales Validation in Italian.","ITA-VALI-DEM","Inclusion Criteria:\n\n* Age ≥ 60 years;\n* Availability of an informant\u002Fcaregiver, able to judge their functional abilities.\n\nFor neurologically unimpaired elderly:\n\n\\- Normal performance on the Mini Mental State Examination (Folstein et al. 1975; Foderaro et al., 2022).\n\nFor clinical groups: Conditions consistent with:\n\n* Subjective Cognitive Decline (Jessen et al., 2014)\n* Mild Cognitive Impairment (Winblad et al., 2004)\n* Mild Major Neurocognitive Disorder according (DSM-5-TR, APA, 2022).\n\nExclusion Criteria:\n\n* Refusal or inability to sign informed consent;\n* For the clinical groups: other neurological or psychiatric conditions that may explain the presence of cognitive difficulties.",true,"ALL","60 Years",{"count":20,"type":21},390,"ESTIMATED","1 Day","OBSERVATIONAL","The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian is not available at present. In particular, the study includes the following functional and behavioral scales: the Katz's index (Basic Activities of Daily Living, BADL), the Lawton and Brody's scale (Instrumental Activities of Daily Living, IADL), the Everyday Cognition questionnaire (E-Cog), the Neuropsychiatric Inventory Questionnaire (NPI-Q) for assessing the Behavioral and Psychological Symptoms of Dementia. Furthermore, a modified Italian version of the Functional Activities Questionnaire (FAQ), which integrates and updates the content of the original items (e.g., addressing the use of technologies, M-FAQ) will be used in the validation study.\n\nThe second aim is to evaluate the psychometric properties of the M-FAQ, the ECog, and the NPI-Q in terms of reliability and validity.\n\nThe third aim is to apply a Receiver Operating Characteristic (ROC) curve analysis to identify cut-offs of IADL, M-FAQ and ECOG to discriminate between different clinical groups (i.e., neurologically unimpaired elderly; Subjective Cognitive Decline, SCD; Mild Cognitive Impairment, MCI; mild Alzheimer's Disease, AD).\n\nNeurologically unimpaired elderly participants (over 60 years old) and participants with SCD, MCI, mild AD, and their caregivers\u002Finformants will undergo: i) administration of the translated versions of the scales; ii) administration of a Cognitive Reserve questionnaire. For SCD, MCI and AD participants, data from the clinical neuropsychological evaluation will also be collected, while paper-and-pencil psychometric tests to assess global cognitive functioning (Mini Mental State Examination) and logical-abstract reasoning (Raven's Colored Matrices) will be administered to the neurologically unimpaired participants.",[26,27,28,29],"Neurologically Unimpaired Elderly Participants","Subjective Cognitive Decline (SCD)","Mild Cognitive Impairment (MCI)","Major Neurocognitive Disorder",[31,32,33,34,35,36,37],"BADL and IADL","FAQ scale","ECog","NPI-Q","Italian adaptation","Validation","Functional and behavioral scales","RECRUITING","2025-02-11",{"date":41,"type":42},"2025-02-13","ACTUAL",{"date":44,"type":42},"2024-11-26",{"date":46,"type":21},"2026-11-30",{"name":48,"class":49},"Casa di Cura IGEA","OTHER",""]