[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nocebo-effect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nocebo-effect":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,70],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100612269",false,"NCT07251387","Muscle Synergies in Pain and Pain Anticipation","Test-retest Fidelity of a Tool for Calculation of Muscle Synergies","Inclusion Criteria:\n\n* Aged 18-35 years old\n* Healthy participant with no self-reported diagnosed neurological, musculoskeletal, or cardiovascular disorders\n* Body Mass Index (BMI) \\\u003C 30\n* Ability to walk unaided for at least 10 minutes without major physical limitations\n\nExclusion Criteria:\n\n* Presence of pain at the time of testing\n* Self-reported diagnosed condition affecting mobility\n* Known allergy to any component of the study cream\n* Allergy to EMG electrode adhesives\n* Inability to stand unassisted for more than 1 minute\n* Inability to walk\u002Frun at the required speed and distance\n* Weight exceeding 150 kg (due to treadmill limitations)\n* Recent intake (prior intervention) of:\n* Analgesics (within 6 hours)\n* Cigarettes (within 6 hours)\n* Caffeine (within 2 hours)\n* Skin lesions at the cream application site\n* Pregnancy\n* Failure to understand instructions\n* Daytime pain reported by participant on day of experimentation",true,"ALL","18 Years","35 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates how the anticipation of pain affects muscle synergies. One group will be recruited who will first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively labeled as capsaicin. The changes in muscle synergies will be measured during walking tasks.",[27,28,29],"Pain","Nocebo Effect","Pain Anticipation",[31,32,27,33,34,35],"Nocebo effect","Pain anticipation","Gait","Motricity","Muscle synergies","RECRUITING","2026-06-08",{"date":39,"type":40},"2026-06-11","ACTUAL",{"date":42,"type":40},"2026-01-01",{"date":44,"type":21},"2027-10-01",{"name":46,"class":47},"Universite de Picardie Jules Verne","OTHER",2,{"id":50,"slug":4,"hasResults":10,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},"100587528","NCT06929559","Muscular Synergies and Behavioral Adaptations of Gait in Pain Anticipation (SYAMAPP)","SYAMAPP","Inclusion Criteria:\n\n* Aged 18-35 years\n* Healthy participant with no self-reported diagnosed neurological, musculoskeletal, or cardiovascular disorders\n* Body Mass Index (BMI) \\\u003C 30\n* Ability to walk unaided for at least 10 minutes without major physical limitations\n\nExclusion Criteria:\n\n* Presence of pain at the time of testing\n* Self-reported diagnosed condition affecting mobility\n* Known allergy to any component of the study cream\n* Allergy to EMG electrode adhesives\n* Inability to stand unassisted for more than 1 minute\n* Inability to walk\u002Frun at the required speed and distance\n* Weight exceeding 150 kg (due to treadmill limitations)\n* Recent intake of:\n* Analgesics (within 6 hours)\n* Cigarettes (within 6 hours)\n* Caffeine (within 2 hours)\n* Skin lesions at the cream application site\n* Pregnancy\n* Failure to understand instructions\n* Daytime pain reported by participant on day of experimentation",{"count":56,"type":21},34,[24],"The purpose of this study is to determine whether the anticipation of pain influences gait control and psychophysiological responses in healthy individuals. Participants will receive a neutral cream described either as potentially painful (experimental group) or inert (control group), and their behavioral and physiological adaptations will be measured during walking tasks.",[28,29],[31,32,61,34,33,62,63,35],"Pain expectation","Walking","Healthy",{"date":39,"type":40},{"date":42,"type":40},{"date":67,"type":21},"2028-10-30",{"name":46,"class":47},1,{"id":71,"slug":4,"hasResults":10,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":69},"100580321","NCT06835777","Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper","Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - Protocol Paper of a Randomised Controlled Study","Inclusion Criteria:\n\n* Healthy adult participants (18+)\n* physically active (WHO, 2020)\n* no medical history pf psychological disorders\u002Fmental health issues\n* no acute or regular medication intake\n* no severe injury to the lower limb within the last 6 months\n* proficient in english\n* normal or corrected eyesight",{"count":77,"type":21},56,[24],"This clinical trial aims to investigate the neurophysiological mechanisms of placebo and nocebo effects on sports performance, using Electroencephalography (EEG) and isometric strength testing of the lower extremities.\n\nThe primary objective of this trial is to identify temporal mechanisms and cortical regions and networks involved in generating placebo and nocebo effects before (expectation) and at onset of athletic performance (perception).\n\nThe trial will include four groups, two of them experimental, one an active control and one natural history, meaning participants in this group will receive no intervention and won't be EEG controlled. Data will be collected on two occasions with baseline data for EEG, expectations and performance as well as key participant characteristics being collected on day one. On day two, in a deceptive process, participants in the two experimental groups will take an inert substance presented as either performance enhancing or inhibiting and subsequently experience a reinforcement of beliefs via exposure to explicit adjectives. EEG data will be collected during reinforcement of beliefs. In the active control group, participants will receive no substance, but this group will follow the same procedure as the experimental groups with neutral adjectives. Participants will then perform isometric strength and fatigue resistance tests on an isometric dynamometer. EEG data as well as subjective data on expectations and rating of perceived exhaustion will be collected.",[81,28],"Placebo Effect",[83,84,85,86],"EEG","Placebo","Nocebo","Sports Performance","NOT_YET_RECRUITING","2025-02-13",{"date":90,"type":40},"2025-02-19",{"date":92,"type":21},"2025-03-01",{"date":94,"type":21},"2025-12-31",{"name":96,"class":47},"Canterbury Christ Church University",""]