[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oxygen-consumption-vo2\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oxygen-consumption-vo2":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100601225",false,"NCT07107724","O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock","Oxygen Consumption And Carbon Dioxide Production Following Hemodynamic Optimization In Shock: The OxyCarDio Study","OxyCarDio","Inclusion Criteria:\n\nHypotension (MAP\\\u003C 65mmHg or sudden drop in MAP \\> 15 mmHg) and one of the following conditions:\n\n* Heart rate \\> 120 bpm\n* Urinary output \\\u003C 0.5 ml\u002Fkg\u002Fh for at least two hours\n* Lactate \\> 2 mmol\u002FL\n\nExclusion Criteria:\n\n* Urgent need for surgery\n* Urgent need for veno-arterial ECMO or severe hemodynamic instability\n* Consistent risk of imminent death\n* Severe ARDS or severe respiratory failure (p\u002FF \\\u003C 100 mmHg) and\u002For FiO2\\>0.8\n* Severe heart failure (NYHA 4 and\u002For EF\\\u003C25%)\n* Need for intermittent or continuous renal replacement therapy (IRRT or CRRT)\n* Anemia defined as Hb\\\u003C8 g\u002FdL\n* VO2 variability \\\u003C 5% throughout ten minutes of stabilization before procedure start\n* Intraabdominal hypertension, defined as intraabdominal pressure \\> 18 mmHg\n* Pregnancy\n* Withdrawal or refuse of informed consent\n* Terminal disease\n* Do-not-resuscitate order.","ALL","18 Years",{"count":19,"type":20},36,"ESTIMATED","OBSERVATIONAL","The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.\n\nThe main questions it aims to answer are:\n\n1. Do common maneuvers for hemodynamic optimization (fluid bolus and\u002For vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator?\n2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas?\n\nParticipants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.",[24,25],"Hemodynamic Instability","Oxygen Consumption (V̇O2)","RECRUITING","2025-07-30",{"date":29,"type":30},"2025-08-06","ACTUAL",{"date":32,"type":30},"2025-07-29",{"date":34,"type":20},"2027-12",{"name":36,"class":37},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",""]