[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pancreatic-fluid-collection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pancreatic-fluid-collection":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100526306",false,"NCT06133023","WONDER-02 Trial: Plastic Stent vs. Lumen-apposing Metal Stent for Pancreatic Pseudocysts","WONDER-02: Plastic Stent vs. Lumen-apposing Metal Stent for Endoscopic Ultrasound-guided Drainage of Pancreatic Pseudocysts-a Multicentre Randomised Non-inferiority Trial","Inclusion Criteria:\n\n* Patients with pancreatic pseudocyst(s) defined by the revised Atlanta classification\n* The longest diameter of a targeted pseudocyst ≥ 5 cm\n* Patients requiring drainage for symptoms associated with a pseudocyst (e.g., infection, gastrointestinal symptoms including abdominal pain, or jaundice)\n* Patients aged 18 years or older\n* Written informed consent obtained from patients or their representatives\n\nExclusion Criteria:\n\n* A pseudocyst that is inaccessible via the EUS-guided approach\n* A plastic or lumen-apposing metal stent in situ\n* Coagulopathy (e.g., platelet count \\\u003C 50,000\u002Fmm3 or prothrombin time international normalised ratio \\[PT-INR\\] \\>1.5)\n* Users of antithrombotic agents that cannot be discontinued according to the Japan Gastroenterological Endoscopy Society \\[JGES\\] guidelines\n* Patients who do not tolerate endoscopic procedures\n* Pregnant women","ALL","18 Years",{"count":18,"type":19},80,"ESTIMATED","INTERVENTIONAL",[22],"NA","Endoscopic ultrasound (EUS)-guided transluminal drainage has become a first-line treatment modality for symptomatic pancreatic pseudocysts. Despite the increasing popularity of lumen-apposing metal stents (LAMSs), the use of a LAMS is limited by its high costs and specific adverse events compared to plastic stent placement. To date, there has been a paucity of data on the appropriate stent type in this setting. This trial aims to assess the non-inferiority of plastic stents to a LAMS for the initial EUS-guided drainage of pseudocysts.",[25,26,27],"Pancreatic Fluid Collection","Pancreatitis","Pancreatic Pseudocyst",[29,30,31,27],"Endosonography","Drainage","Stents","NOT_YET_RECRUITING","2023-11-09",{"date":35,"type":36},"2023-11-15","ACTUAL",{"date":38,"type":19},"2023-11",{"date":40,"type":19},"2033-09",{"name":42,"class":43},"Tokyo University","OTHER",26,{"id":46,"slug":4,"hasResults":10,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100473977","NCT05451901","Immediate Necrosectomy vs. Step-up Approach for Walled-off Necrosis","Immediate Necrosectomy vs. Step-up Approach After EUS-guided Drainage of Walled-off Necrosis: a Multicenter Randomized Controlled Trial (WONDER-01)","WONDER-01","Inclusion Criteria:\n\n* Patients with WON defined according to the revised Atlanta classification\n* The longest diameter of WON is 4 cm or larger\n* Patients with at least one out of the following conditions; signs of infection, gastrointestinal symptoms, abdominal symptoms, obstructive jaundice\n* Patients who need drainage for WON\n* Age of 18 years or older\n* Patients or their representatives provide informed consent\n* Patients who visit or are hospitalized at the participating institutions\n\nExclusion Criteria:\n\n* WON inaccessible by EUS-guided approach\n* AXIOS stent has already been placed into the WON prior to the enrollment\n* Severe coagulopathy; Platelet count \\\u003C 50,000\u002Fmm3 or prothrombin time international normalized ratio (PT-INR) \\>1.5\n* Patients on antithrombotic agents which cannot be managed according to the \"guideline for gastroenterological endoscopy in patients undergoing antithrombotic treatment (Dig Endosc. 2014 Jan;26(1):1-14.)\"\n* Patients who cannot tolerate endoscopic procedures\n* Pregnant women\n* Patients considered inappropriate for inclusion by investigators",{"count":53,"type":19},70,[22],"Walled-off necrosis (WON) is a pancreatic fluid collection, which contains necrotic tissue after four weeks of the onset of acute pancreatitis. Interventions are required to manage patients with infected WON, for which endoscopic ultrasonography (EUS)-guided drainage has become a first-line treatment modality. For patients who are refractory to EUS-guided drainage, the step-up treatment including endoscopic necrosectomy (EN) and\u002For additional drainage is considered to subside the infection. Recent evidence suggests that EN immediately after EUS-guided drainage may shorten treatment duration without increasing adverse events. In this randomized trial, the investigators will compare treatment duration between EN immediately after EUS-guided drainage versus the step-up approach in patients with symptomatic WON.",[25,57,58,27],"Walled-off Necrosis","Pancreatitis, Acute Necrotizing",[29,30,31,60,61],"Endoscopic necrosectomy","Step-up approach","RECRUITING","2022-10-26",{"date":65,"type":36},"2022-10-27",{"date":67,"type":36},"2022-07-29",{"date":69,"type":19},"2031-04-11",{"name":42,"class":43},21,""]