Patellofemoral Pain

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Review clinical trials related to Patellofemoral Pain. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Evaluating the Effectiveness of Clinical Practice Guideline Adherence for Patellofemoral Pain

The overall goal of this multisite, randomized clinical trial is to evaluate the short- and long-term effectiveness of a Clinical Practice Guideline (CPG)-adherent physical therapy approach to patellofemoral pain (PFP) management among military Service members. The main questions it aims to answer are: 1. Can a CPG-adherent care approach to PFP management improve short- and long-term knee function, pain, and confidence with completing duty-related activities? 2. Can a CPG-adherent care approach to PFP management reduce utilization of healthcare resources and analgesic medication prescription at 12-month follow-up? 3. Are there patient- and care-specific factors that predict or mediate clinical benefit from physical therapy care for PFP? Researchers will compare the CPG-adherent physical therapy intervention to usual physical therapy care in the Military Health System. Participants will: 1) be randomized to receive CPG-adherent care or usual care for PFP management; 2) attend physical therapy corresponding to their group assignment; and 3) complete patient-reported outcome measures at baseline and 6-weeks and 3-, 6-, and 12-months post-randomization.

Participants needed: 440
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Sara Gorczynski, PT, DPTUpdated: May 6, 2026Locations: 1
Eligibility criteria

Active-duty Service member [+3]

Presence of tibiofemoral OA based on imaging evidence in the electronic health r... [+7]

Status: Recruiting

Vibration on Patellofemoral Joint Pain After ACLR

Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing in direction while running, cutting and pivoting on a planted foot have resulted in a majority of ACL injuries. Even after ACL reconstruction (ACLR) surgeries, study has reported a 30-50% prevalence of developing patellofemoral joint (PFJ) pain in 1-2 years post-operation. Whole body vibration (WBV) therapy has been gaining attention as an effective method of training in recent years. It has been proved to have a positive effect on improving muscle strength, muscle activities, muscle power and loading during drop jump. Though duration of WBV may differ according to the effect of interest, several studies have had positive results with a 8 week WBV therapy in increasing muscle strength, proprioception, and post-ACLR knee functions. Further investigation on the underlying mechanism and possible application are to be continued to explore more possibilities with the WBV therapy.

Participants needed: 50
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: Mar 18, 2026Locations: 1
Eligibility criteria

Age between 18 to 60 [+3]

Age > 60 [+5]

Status: Recruiting

Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain

The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population.

Participants needed: 60
Trial details
Age: 18-59Biological sex: FemaleType: InterventionalSponsor: Loma Linda UniversityUpdated: Feb 4, 2026Locations: 1
Eligibility criteria

History of active Patellofemoral Pain for at least 6 months [+3]

History of musculoskeletal surgery or fractures on the tested leg or lumbar spin... [+3]

Status: Recruiting

Emovi 3D Knee Assessment Device Intervention for Operational Readiness

This is a randomized clinical trial investigating the use of the Emovi Knee Kinesiography information in the treatment of anterior knee pain in physical therapy.

Participants needed: 180
Trial details
Age: 18-50Biological sex: AllType: InterventionalSponsor: Womack Army Medical CenterUpdated: Jul 16, 2025Locations: 2
Eligibility criteria

Age 18-50 [+2]

Pregnancy [+5]

Status: Not yet recruiting

Effects of Percutaneous Neuromouldation of the Saphenous Nerve in Patients With Patellofemoral Pain

The knee is a common source of musculoskeletal pain, with patellofemoral pain (PFP) standing out due to its high prevalence. This pain, frequent in adolescents and athletes, significantly impacts the quality of life by hindering daily activities such as climbing stairs and sitting for extended periods. Percutaneous neuromodulation of the saphenous nerve (PNM) emerges as a promising therapeutic approach in physiotherapy to alleviate these symptoms. A randomized controlled clinical trial is proposed in adults with PFP. Participants will be divided into two groups: one will receive PNM of the saphenous nerve, while the other will be a control group receiving puncture without electrical stimulation. Pain, extension strength, and knee range of motion will be evaluated before and after the intervention using the AKPS scale. Three sessions will be conducted with specific intervals, and a follow-up assessment will be performed three months later.

Participants needed: 24
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: University of AlcalaUpdated: Jul 17, 2024Locations: 1
Eligibility criteria

Be 18 years or older. [+2]

Previous surgical intervention on the painful knee. [+9]