[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-surgical-corneal-decompensation-irreversible\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-surgical-corneal-decompensation-irreversible":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100387062",false,"NCT04319848","Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty","Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty (TE-EK)","TE-EK","Inclusion Criteria:\n\nPatients who have mild to moderate corneal endothelial decompensation or bullous keratopathy, but with minimal corneal stromal scarring resulting from a variety of conditions including:\n\n* Fuchs' endothelial dystrophy\n* Post-surgical corneal decompensation (irreversible) - all forms of pseudophakic or aphakic bullous keratopathy\n\nExclusion Criteria:\n\n* Severe forms or late stage presentation of corneal decompensation with severe corneal stromal scarring, unsuitable for TE-EK surgery as opposed to penetrating keratoplasty\n* Patients with complex anterior segment complications precluding a successful TE-EK procedure\n* Patients who have other forms of endothelial dystrophy, traumatic corneal decompensation, or post-inflammatory corneal decompensation\n* Post-laser iridotomy or glaucoma related corneal decompensation\n* Patients not keen to participate in the clinical trial\n* Patients who are below 21 years of age or above 80 years of age\n* Patients who are pregnant\n* Patients who are cognitively impaired\n* Patients who are prisoners\n* Patients who are allergic to antibiotics","ALL","21 Years","80 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","Assessment of safety and efficacy of tissue-engineered corneal endothelial graft material generated using cultured human corneal endothelial cells for tissue-engineered endothelial keratoplasty (TE-EK).",[27,28,29,30],"Mild to Moderate Corneal Endothelial Decompensation","Bullous Keratopathy","Fuchs' Endothelial Dystrophy","Post-surgical Corneal Decompensation (Irreversible)","RECRUITING","2025-09-05",{"date":34,"type":35},"2025-09-12","ACTUAL",{"date":37,"type":35},"2017-12-01",{"date":39,"type":21},"2028-06",{"name":41,"class":42},"Singapore Eye Research Institute","OTHER",""]