[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-oral-mucositis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-oral-mucositis":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":4,"enrollmentInfo":16,"targetDuration":4,"studyType":19,"phases":20,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100616510",false,"NCT07306546","Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer","Inclusion Criteria:\n\n* Diagnosed with oral cancer and receiving microsurgical free flap reconstruction.\n* Age 18 years or older.\n* Conscious and able to follow study instructions.\n* Able to communicate without difficulty in Mandarin, Taiwanese, or through written communication.\n\nExclusion Criteria:\n\n* Abnormal salivary gland function or severe xerostomia.\n* Recent use of antibacterial mouthwash or antibiotic therapy that may affect oral microbiota.\n* Presence of severe bacterial or viral oral infections, or significant periodontal disease.","ALL","18 Years",{"count":17,"type":18},36,"ESTIMATED","INTERVENTIONAL",[21],"NA","This study employs a Randomized Controlled Trial (RCT) design. Patients diagnosed with oral cancer by the attending physician and who meet the inclusion criteria will be admitted to the study after receiving a full explanation of the study objectives, intervention methods, potential risks, and participant rights from the research team upon their stable transfer to the plastic surgery ward post-operation. Written consent will be obtained from the patient and\u002For their legally authorized representative after adequate informed consent has been provided, before they are enrolled in the study.",[24,25,26,27,28],"Oral Squamous Cell Carcinoma (OSCC)","Postoperative Pain","Postoperative Oral Mucositis","Free Flap Reconstruction","Oral Cancer",[30,31,32,33,34],"Hydrogen water","Oral cancer","Free flap reconstruction","Pain assessment","Salivary Biomarkers","NOT_YET_RECRUITING","2025-12-25",{"date":38,"type":39},"2025-12-29","ACTUAL",{"date":41,"type":18},"2026-01",{"date":43,"type":18},"2027-10-31",{"name":45,"class":46},"Kaohsiung Medical University Chung-Ho Memorial Hospital","OTHER",""]