[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quadrantanopsia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quadrantanopsia":59},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":5},"100519758",false,"NCT06047717","Vision Loss Impact on Navigation in Virtual Reality","The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality","Cortically Blind Group:\n\nInclusion Criteria:\n\n* Residents of the United States or Canada\n* Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and\u002For CT scans)\n* Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.\n* Willing, able, and competent to provide their own informed consent\n* Cognitively able, responsible to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Those who have never driven or earned a drivers' license\n* Past or present ocular disease interfering with visual acuity\n* Best corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Sustained damage to the dorsal lateral geniculate nucleus\n* Presence of diffuse, whole-brain degenerative processes\n* Presence of brain damage deemed by study staff to potentially interfere with outcome measures\n* History of traumatic brain injury\n* Documented history of drug\u002Falcohol abuse\n* Diagnosis of cognitive or seizure disorders\n* Diagnosis of one-sided attentional neglect\n\nControl Group:\n\nInclusion Criteria:\n\n* Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above\n* Competent and responsible, as determined by the Principal Investigator\n* Willing, able, and competent to provide their own informed consent\n* Normal cognitive abilities, be able to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Subjects who have never driven or earned a drivers' license\n* BCVA worse than 20\u002F40 in either eye\n* Presence of vision loss from ocular diseases or disorders\n* Presence of a visual field defect\n* Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly\n* Subjects with a history of neurological disorders\n* Subjects with a history of TBI\n* Persons who lack the competence or are otherwise unable to perform the visual testing as directed.",true,"ALL","21 Years","75 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).",[27,28,29,30,31,32,33,34,35,36,37],"Stroke, Ischemic","Quadrantanopia","Hemianopsia, Homonymous","Hemianopia, Homonymous","Hemianopia","Hemianopsia","Occipital Lobe Infarct","Visual Field Defect, Peripheral","Vision Loss Partial","Quadrantanopsia","Stroke Hemorrhagic",[39,40,41,42,43,44,45,46],"Occipital stroke","Vision loss after stroke","Vision recovery","Vision restoration","Partial vision loss","Homonymous quadrantanopsia","Homonymous quadrantanopia","stroke","RECRUITING","2026-01-07",{"date":50,"type":51},"2026-01-09","ACTUAL",{"date":53,"type":51},"2023-11-28",{"date":55,"type":21},"2028-10",{"name":57,"class":58},"University of Rochester","OTHER",""]