[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rotator-cuff-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rotator-cuff-injuries":687},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,35,0,25,[9,42,84,118,140,168,198,223,253,280,306,331,362,387,417,443,463,484,507,533,558,584,609,632,659],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100053385",false,"NCT06289686","Rotator Cuff Repairs With or Without BioEnthesis™ Augmentation","Inclusion Criteria:\n\n* DEERS-eligible\n* Adults, between the ages of 18-65 (inclusive)\n* Presenting with a rotator cuff tear that is reparable surgically (a reparable tear is defined as tear of the RC where it is possible to bring the retracted tendon edge back to the greater tuberosity of the humerus under minimal tension)\n* Ability to undergo surgery to repair rotator cuff tear\n* Willingness to commit to study procedures including study intervention and a 12-month follow-up\n* Fluency in speaking, reading, comprehending English\n* 1-2 tendon full thickness reparable RC tear (full thickness tear is defined as a tear that involves the majority of supraspinatus and less than half of the infraspinatus under minimal tension, with no subscapularis involvement beyond the upper border)\n* Patients who have high-grade partial thickness tears where the surgeon elects to complete the tear during surgery before repairing the tendon(s)\n\nExclusion Criteria:\n\n* Previous shoulder surgery (excluding acromioplasty or diagnostic arthroscopy)\n* Inability to receive an MRI\n* Current (within the past 6 months) tobacco user\n* Unwilling to remain tobacco free for the duration of the study\n* Current lower limb injuries requiring walking assist devices such as crutches and walkers\n* Diagnosed with systemic arthritis\n* Significant neck pathology\n* Active joint or systemic infection\n* Currently enrolled, or plans to enroll, in another clinical trial during this study (that would affect the patient's safety or results of this trial)\n* Significant muscle paralysis of the shoulder girdle\n* Currently pregnant or plans to become pregnant during this study\n* Inability of the surgeon to repair the tear with remaining defect no greater than 10 mm in diameter\n* Inability of the surgeon to repair the tear with less than 1cm of medialization\n* Evidence of other significant shoulder pathology (such as Grade III osteoarthritis)\n* Has a history of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or drug abuse or addiction\n* Major medical illness that would preclude undergoing surgery\n* Major psychiatric illness or developmental handicap\n* Goutallier III classification and above","ALL","18 Years","65 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Rotator cuff (RC) injuries are particularly prevalent, difficult to repair, and attachment between the bone and tendon is notoriously difficult to achieve. The most common method and current standard of care (SOC) for reattaching connective tissues (e.g., ligaments, tendons) to bone typically involves suture anchor-based techniques, but this is fraught with problems. More specifically, re-tearing of the connective tissue after this procedure occurs in 30-60% of cases, and can be even higher in patients who engage in smoking, have a diagnosis of diabetes, etc. To address these clinical challenges, Sparta Biopharma Inc. (Sparta) developed a unique technology, called BioEnthesis, to improve the connection between the tendon and bone. Pre-clinical in vivo studies demonstrated that the biphasic bovine cancellous matrix regenerated at the bone-soft tissue interface-thereby leading to high structural integrity and will likely lead to reduced re-tear rates over time. The investigators hypothesize that patients in this interventional cohort will experience enhanced mobility, reduced pain, and less re-tears after RC procedures versus a standard suture anchor-based repair.",[26,27,28],"Rotator Cuff Tears","Rotator Cuff Injuries","Surgery","RECRUITING","2026-07-10",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":33},"2023-07-28",{"date":37,"type":20},"2027-08",{"name":39,"class":40},"Brooke Army Medical Center","FED",5,{"id":43,"slug":4,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":83},"100053446","NCT07699744","Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery","Pain Management Protocol Optimization for Rebound Pain Prevention and Enhanced Recovery After Shoulder Surgery: A Randomized Noninferiority Trial of Intravenous Dexamethasone Combined With Single-Shot Versus Continuous Brachial Plexus Block","Inclusion Criteria:\n\n* Adult patients aged 19 to 79 years scheduled for elective shoulder surgery under brachial plexus block and monitored anesthesia care (MAC)\n\nExclusion Criteria:\n\n* Pre-existing neurological deficit of the brachial plexus\n* Emergency surgery\n* American Society of Anesthesiologists (ASA) physical status classification IV or higher\n* Contraindication or history of hypersensitivity to local anesthetics or dexamethasone\n* Severe pulmonary disease (e.g., chronic obstructive pulmonary disease)\n* Body mass index (BMI) ≥ 35 kg\u002Fm²\n* Long-term use of steroids\n* Long-term use of analgesics\n* Inability to cooperate or communicate\n* Pregnancy","19 Years","79 Years",{"count":51,"type":20},92,[23],"Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area. However, when the effect of a single-injection nerve block wears off, many patients experience sudden, intense pain known as \"rebound pain\".\n\nOne way to prevent rebound pain is to place a thin catheter near the nerves so that local anesthetic can be given continuously for a longer period (continuous nerve block). However, this method is technically demanding and can cause problems such as catheter dislodgement, infection, and inconvenience for patients. Another simpler option is to give a single-injection nerve block together with an intravenous (IV) injection of dexamethasone, a steroid medication known to prolong the effect of nerve blocks and reduce rebound pain.\n\nThe purpose of this study is to determine whether a single-injection nerve block combined with IV dexamethasone (5 mg) is not inferior to a continuous nerve block in preventing rebound pain after shoulder surgery. A total of 92 adult patients scheduled for elective shoulder surgery will be randomly assigned to one of the two groups. The main outcome is the rebound pain score, defined as the difference between the last pain score recorded in the recovery room (while the nerve block is still working) and the highest pain score reported within the first 24 hours after the nerve block. The investigators expect that the simpler single-injection method with IV dexamethasone will provide comparable pain control while avoiding the complications and inconvenience of catheter-based continuous nerve blocks.",[55,56,57,27],"Pain, Postoperative","Rebound Pain","Shoulder Injuries",[59,60,61,62,63,64,65,66,67,68,69,70,71,72],"Rebound pain","Interscalene brachial plexus block","Single-shot nerve block","Continuous peripheral nerve block","Perineural catheter","Dexamethasone","Intravenous dexamethasone","Shoulder surgery","Rotator cuff repair","Regional anesthesia","Postoperative analgesia","Multimodal analgesia","Non-inferiority trial","Enhanced recovery after surgery","NOT_YET_RECRUITING","2026-07-09",{"date":32,"type":33},{"date":77,"type":20},"2026-07-15",{"date":79,"type":20},"2027-07-15",{"name":81,"class":82},"Seoul National University Hospital","OTHER",1,{"id":85,"slug":4,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":15,"minAge":16,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":83},"100610542","NCT07228936","The Role of Pectoralis Minor Tightness in the Development of Rotator Cuff Tears","The Role of Pectoralis Minor Muscle Tightness in the Development of Rotator Cuff Tears: A Propensity Score Matched Case-Control Study","PMinor-Rotator","Inclusion criteria consisted of patients aged 18-55 years who were scheduled to undergo surgical treatment for a partial-thickness rotator cuff tear (case group) and individuals aged 18-55 years with no evidence of rotator cuff or other shoulder pathology on magnetic resonance imaging (control group). Patients were excluded if they had a history of trauma, thoracic outlet syndrome, systemic inflammatory disease, prior surgery on the affected shoulder, and declined participation in the examination.",true,"55 Years",{"count":94,"type":20},90,"OBSERVATIONAL","This study investigates whether tightness of a small chest muscle called the pectoralis minor is associated with the development of partial rotator cuff tears in the shoulder. Using a propensity score matched case-control design, the study compares patients with rotator cuff tears (case group, n=45) to patients with intact rotator cuffs (control group, n=45).\n\nAdults aged 18-55 with shoulder pain who are evaluated by MRI and\u002For shoulder arthroscopy at Gazi University Hospital may be invited. The case group includes patients found to have partial rotator cuff tears during arthroscopy. The control group includes patients whose rotator cuff was documented as intact by MRI. Groups are matched 1:1 on age, sex, BMI, and dominant side.\n\nBefore surgery, two trained clinician measures shoulder posture and pectoralis minor length using simple external tools (a digital caliper and ruler-like square). For arthroscopy patients, the surgeon records general arthroscopic findings. No extra procedures are added for research.\n\nWe expect to include 90 participants total. The primary hypothesis is that pectoralis minor tightness is more prevalent in patients with rotator cuff tears compared to controls. A secondary hypothesis is that tears in patients with pectoralis minor tightness more often partial-thickness bursal side rotator cuff tear. Results may help clinicians understand shoulder mechanics and improve prevention or rehabilitation strategies.",[98,27,99,100],"Shoulder Impingement Syndrome","Pectoralis Minor Tightness","Pectoralis Minor Muscle Tension",[102,27,103,104,105,106,107,108],"rotator cuff","Posture","Scapula","Pectoralis Muscles","Arthroscopy","Shoulder Joint","Pectoralis Minor","2026-06-20",{"date":111,"type":33},"2026-06-25",{"date":113,"type":33},"2025-03-18",{"date":115,"type":20},"2026-06-30",{"name":117,"class":82},"Gazi University",{"id":119,"slug":4,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":126,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":83},"100638867","NCT07628244","Comparison of Two General Anesthesia Maintenance Strategies on Intraoperative Visibility During Arthroscopic Rotator Cuff Surgery: A Randomized Trial","CLEAR-SHOULDER","Inclusion Criteria:\n\n1. Patient aged 18 or over\n2. Patient scheduled for elective rotator cuff repair arthroscopy (RCRA), performed in the \"beach-chair\" position under general anesthesia combined with an interscalene block (with or without standard associated procedures such as acromioplasty and\u002For tenotomy\u002Ftenodesis of the long biceps). Procedures for instability (Bankart\u002FLatarjet), fractures, capsulitis, simple lavage, or any arthroscopy not focused on rotator cuff repair (RCR) are not eligible.\n3. Patient with an ASA score of I to IV\n4. Patient affiliated to a social security scheme,\n5. Patient having given written consent following written and oral information.\n\nExclusion Criteria:\n\n1. Patients with a contraindication to any of the study agents, including known hypersensitivity or allergy to any of these agents or to any of their excipients.\n2. Patients with known coagulopathy (abnormal PT\u002FINR; platelets \\\u003C 100,000\u002FL) or\n3. Patients with active preoperative hemarthrosis or local infection.\n4. Non-elective (emergency) surgery or a procedure whose initial objective is not rotator cuff repair arthroscopy (RCRA). Note: Intraoperative conversion to open surgery is not an exclusion criterion; it will be considered an intraoperative event and managed in the analysis according to the intention-to-treat (ITT) principle, with a sensitivity analysis procedure described in the statistical plan.\n5. Uncooperative patient, inability to consent\n6. Pregnant women\n7. Patient protected by law under guardianship or curatorship, or unable to participate in a clinical study under article L. 1121-16 of the French Public Health Code.",{"count":125,"type":20},110,[127],"NA","Shoulder arthroscopy is one of the most common orthopedic procedures, and the quality of the surgeon's view inside the joint is critical to its safety and success. Unlike limb surgery, no tourniquet can be applied to the shoulder, so surgical visibility depends almost entirely on how much bleeding occurs within the joint - which is itself influenced by the anesthetic drugs used to keep the patient asleep.\n\nTwo standard techniques exist for maintaining general anesthesia: inhaled anesthesia (sevoflurane) and total intravenous anesthesia (TIVA, using propofol). Evidence from other types of keyhole surgery (nasal, ear) suggests that propofol may produce better surgical visibility, possibly because sevoflurane causes slightly greater dilation of the smallest blood vessels in tissue, leading to more bleeding into the joint. However, in shoulder arthroscopy specifically, the data are scarce and contradictory.\n\nCLEAR-SHOULDER is a randomized, single-blind trial designed to determine whether propofol-based intravenous anesthesia provides superior intraoperative visibility compared to sevoflurane-based inhaled anesthesia during arthroscopic rotator cuff repair. Surgical visibility will be assessed from blinded video recordings of each procedure using the validated modified Fromme-Boezaart score. An exploratory artificial intelligence analysis of the arthroscopic videos will also be conducted.\n\nSecondary outcomes include operating time, irrigation fluid consumption, hemodynamic stability, vasopressor requirements, surgeon satisfaction, postoperative recovery, and environmental impact of each anesthetic strategy.",[27,130,106],"Anesthesia, General","2026-06-19",{"date":133,"type":33},"2026-06-24",{"date":135,"type":33},"2026-06-18",{"date":137,"type":20},"2028-03-18",{"name":139,"class":82},"Centre Hospitalier Universitaire de Nice",{"id":141,"slug":4,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":15,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":4},"100642907","NCT07592936","Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears","Effects and Benefits of Repeated Injections of Adipose-derived Stem Cells on Shoulder Function in Rotator Cuff Tears: A Randomized Controlled Study","Inclusion Criteria:\n\n* Clinical signs and symptoms compatible with a traumatic RCT\n* MR verified supraspinatus tear\n* Reparable lesion with tendon retraction \\\u003C 2 cm.\n* Fatty infiltration level 0-2 according to Fuchs or out of 5 based on Goutalliers classification\n* No history of inflammatory disease\n* Negative infectious disease marker tests Signed consent to the study\n\nExclusion Criteria:\n\n* Former surgery in the affected shoulder\n* Signs of infection\n* Immunosuppression (due to clinical condition or medical therapy)\n* Any malignancy within 5 years prior to screening\n* Previous radiotherapy to the shoulder\n* BMI under 18\n* BMI above 35\n* Allergy to antibiotics such as penicillin\n* Coagulopathy","30 Years","69 Years",{"count":149,"type":20},30,[151,152],"PHASE1","PHASE2","The aim of the project is to investigate whether repeated implantations of micro-fragmented adipose tissue (MFAT), into the shoulder muscle can improve the outcome of standard surgical treatment for rotator cuff tears (RCT). The investigators hypothesize that combining surgery with repeated implantations of micro-fragmented adipose tissue (MFAT) into the muscle provides a more effective treatment for patients with rotator cuff tears compared to standard surgical treatment. The result would be better outcomes such as improved shoulder functioning and reduced pain.",[26,27,155],"Stem Cells",[157,158],"Adipose derived stem cells","ADSC","2026-06-09",{"date":161,"type":33},"2026-06-12",{"date":163,"type":20},"2026-08",{"date":165,"type":20},"2028-08",{"name":167,"class":82},"University of Southern Denmark",{"id":169,"slug":4,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":175,"targetDuration":177,"studyType":95,"phases":4,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":197},"100581959","NCT06857084","Evaluation Of Outcomes Following Rotator Cuff Repair Using the REGENETEN Bioinductive Implant","Evaluation Of Clinical and Health Economic Outcomes Following Rotator Cuff Repair Using the REGENETEN◊ Bioinductive Implant: A Prospective, Multi-Center Global Registry","RePaRe","Inclusion Criteria:\n\n* Subject requires Arthroscopic rotator cuff repair (ARCR);\n* Patients aged over 18 years old at the time of consent and providing baseline data before undergoing rotator cuff repair surgery (either partial or full thickness tears) will be eligible for this prospective registry.\n\nExclusion Criteria:\n\n* Subject who, in the opinion of the Investigator, has an emotional or neurological condition that would pre-empt their ability or willingness to participate in the registry including mental illness, intellectual disability, and drug or alcohol abuse.\n* Subjects who do not meet the indication or are contraindicated according to specific Smith+Nephew REGENETEN System's Instructions for Use (IFUs);\n* Subject that meets the definition of a Vulnerable Subject per ISO14155:2020 Section 3.44.",{"count":176,"type":20},400,"7 Years","This prospective, single-arm, multicenter registry is being conducted to collect real world post-market data from patients who are undergoing rotator cuff repair using the REGENETEN◊ Bioinductive Implant System. The Registry will include up to 50 centers in the United Kingdom (UK), Europe, Australia, and up to 400 patients for the initial evaluation.\n\nPatients will be treated and evaluated according to standard medical care. Outcome data is collected up to 2 years post-surgery.",[27],[181,182,183,184,185,186],"Rotator Cuff Repair","Rotator Cuff Tear","Full Thickness Tear","Partial Thickness Tear","Massive Tear","REGENETEN Bioinductive Implant","2026-05-28",{"date":189,"type":33},"2026-06-01",{"date":191,"type":33},"2020-10-01",{"date":193,"type":20},"2029-12-31",{"name":195,"class":196},"Smith & Nephew, Inc.","INDUSTRY",22,{"id":199,"slug":4,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":15,"minAge":203,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":206,"conditions":207,"keywords":209,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":83},"100508867","NCT05906004","Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff","Inclusion Criteria:\n\n* Patient has been treated using a Pitch-Patch device for augmentation or reinforcement of the rotator cuff 2-2.5years prior to enrolment.\n* Patient has a baseline Constant Murley Score (CMS), assessed within 30 days prior to implantation of the device.\n* Patient must be 16 years old or above.\n* Patient is willing to participate in the study, and having been informed of the nature of the study, has provided written informed consent as approved by the Ethics Committee (EC).\n\nExclusion Criteria:\n\n\\- The Pitch-Patch has been used outside its intended use.","16 Years",{"count":205,"type":20},37,"This is a clinical investigation study. It will verify the long-term safety and performance of the Pitch-Patch when implanted to reinforce partially repairable rotator cuff tears and used as described by the manufacturer's instructions.\n\nThe medical device in this study is already on the market and is manufactured by Xiros Ltd.\n\nThe Pitch-Patch is a single-use polyester prosthesis available in two sizes (30x20mm and 35x25mm). It is reinforced around the perimeter and around each eyelet to provide strength and stability to the device and repair.\n\nThe study will collect data on patients who meet the entry criteria and have received the device.\n\nThis is a single-armed study, meaning all patients will have a Pitch-Patch. The total length of the study is expected to be 3 years.\n\nA minimum of 37 patients will be enrolled into the study. Patients will be enrolled at a study specific follow up visit 2-2.5 years after implant, and data for baseline, procedure, and other time points prior to 2 years (3month, 6month, and 1 year post surgery) will be collected retrospectively from medical records if available.",[182,26,208,27],"Rotator Cuff Tears of the Shoulder",[210,181,211,212,213],"Rotator Cuff Reinforcement","Pitch-Patch","Xiros","Rotator Cuff Augmentation","2026-05-12",{"date":216,"type":33},"2026-05-15",{"date":218,"type":20},"2026-05",{"date":220,"type":20},"2029-12",{"name":222,"class":196},"Xiros Ltd",{"id":224,"slug":4,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":230,"targetDuration":4,"studyType":21,"phases":232,"briefSummary":233,"conditions":234,"keywords":237,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":83},"100638286","NCT07587931","Concentric vs Eccentric Full Can Exercise in Partial Rotator Cuff Tears","Comparison of the Effects of Concentric and Eccentric Full Can Exercises on Supraspinatus Muscle Architecture in Individuals With Partial Rotator Cuff Tears","FULLCAN-PRCT","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Diagnosed with partial supraspinatus tendon tear confirmed by ultrasound or magnetic resonance imaging\n* Shoulder pain lasting at least 3 months\n* Pain intensity ≥3 on the Visual Analog Scale (VAS)\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Full-thickness rotator cuff tear\n* History of shoulder surgery\n* Shoulder instability\n* Neurological disorders\n* Rheumatological diseases\n* Corticosteroid injection within the last 3 months\n* Inability to adhere to the exercise program",{"count":231,"type":20},60,[127],"This study aims to compare the effects of concentric and eccentric full can exercises on supraspinatus muscle architecture in individuals with partial rotator cuff tears.\n\nRotator cuff tears are a common cause of shoulder pain and functional limitation. The supraspinatus muscle plays a key role in shoulder movement and stability, and its structure may be affected in individuals with partial tears.\n\nExercise-based rehabilitation is widely used in the conservative management of these conditions. The full can exercise is commonly prescribed to selectively activate the supraspinatus muscle. However, the effects of different contraction types, specifically concentric and eccentric exercises, on muscle structure and clinical outcomes are not fully understood.\n\nIn this study, participants will be randomly assigned to either a concentric or eccentric full can exercise group. Both groups will receive a standard physiotherapy program, including therapeutic ultrasound and transcutaneous electrical nerve stimulation (TENS), in addition to the assigned exercise protocol.\n\nThe intervention will last for 6 weeks, with sessions performed three times per week. Outcomes will be assessed before and after the intervention.\n\nThe primary outcome is the change in supraspinatus muscle pennation angle measured by ultrasound imaging. Secondary outcomes include muscle architecture parameters, pain intensity, range of motion, muscle strength, functional status, and kinesiophobia.\n\nThe findings of this study may help improve exercise selection in the rehabilitation of individuals with rotator cuff tears.",[235,27,236],"Partial Rotator Cuff Tears","Shoulder Pain Syndrome",[238,239,240,241,242,243],"Supraspinatus Muscle","Full Can Exercise","Eccentric Exercise","Concentric Exercise","Shoulder Rehabilitation","Muscle Architecture","2026-05-07",{"date":246,"type":33},"2026-05-14",{"date":248,"type":20},"2026-05-20",{"date":250,"type":20},"2027-01-20",{"name":252,"class":82},"Firat University",{"id":254,"slug":4,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":15,"minAge":260,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":276,"leadSponsor":278,"locationsCount":83},"100634901","NCT07545707","Radiologist-Integrated Finite Element Framework for Acromial Stress in Reverse Shoulder Arthroplasty","From Clinical Grading to Mechanical Vulnerability: A Radiologist-Integrated Parametric Finite Element Study of Progressive Cuff Deficiency and Acromial Overload in Reverse Shoulder Arthroplasty","RIFA-RSA","Inclusion Criteria:\n\n* Adult patients (60-80 years) with cuff tear arthropathy (Hamada grade 3 or above, Walch glenoid B\u002FC) scheduled for primary unilateral reverse shoulder arthroplasty\n* Availability of preoperative high-resolution CT (voxel 1 mm or less) and 1.5T\u002F3T MRI\n* Written informed consent for prospective use of anonymised data\n\nExclusion Criteria:\n\n* Revision RSA or history of prior shoulder prosthetic complications\n* Uncorrectable imaging artefacts\n* Post-RSA follow-up shorter than 6 months","60 Years","80 Years",{"count":263,"type":20},13,"The current prospective single-center study is designed to examine an approach that utilizes both high-resolution CT and MRI scans, coupled with customized finite element modelling to analyze the stress placed on the acromion of patients who have undergone RSA surgery. The degree of rotator cuff deficiency will be assessed using Goutallier classification and quantified as Cuff Deficiency Index (CDI), which directly provides biomechanical information for calculating deltoid forces used in finite element analysis. Von Mises stresses will then be analyzed in anatomically defined acromial zones (Levy zones I-III).",[27,266],"Shoulder Fractures",[268,269,270,102,271],"reverse shoulder arthroplasty","finite element analysis","acromial fracture","biomechanics","2026-05-06",{"date":274,"type":33},"2026-05-11",{"date":189,"type":20},{"date":277,"type":20},"2027-03-05",{"name":279,"class":82},"University of Molise",{"id":281,"slug":4,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":21,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":83},"100635670","NCT07555704","Remote App-based Rehabilitation After Rotator Cuff Repair","Effectiveness of a Combined Intervention Incorporating a Remote Rehabilitation Application for Patients After Arthroscopic Repair of Rotator Cuff Tears: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Demographics: Individuals aged 18 years or older.\n* Diagnosis: Confirmed symptomatic rotator cuff tear requiring surgical intervention, specifically involving:\n\n  * Clinical Presentation: Persistent shoulder pain and functional deficits (e.g., positive impingement signs or weakness in abduction\u002Fexternal rotation) consistent with rotator cuff pathology.\n  * Radiological Confirmation: Imaging evidence (MRI or high-resolution ultrasound) of a full-thickness supraspinatus and\u002For infraspinatus tendon tear.\n  * Tear Characteristics: Small-to-medium-sized tears (maximum diameter \\\u003C 5 cm) categorized as reparable by the attending surgeon.\n* Surgical Procedure: Patients undergoing primary arthroscopic rotator cuff repair (ARCR) utilizing a standardized double-row suture bridge technique.\n* Rehabilitation Adherence: Commitment to follow the standardized postoperative rehabilitation protocol as prescribed by the study.\n* Cognitive and Functional Capacity:\n\n  * Absence of cognitive impairment, with the ability to comprehend and execute complex exercise instructions.\n  * Proficiency in digital literacy, including the regular use of an internet-enabled electronic device (smartphone, tablet, or computer) capable of video-based communication and data transmission.\n* Documentation and Consent:\n\n  * Availability of comprehensive medical records, including pre- and postoperative clinical and radiological data.\n  * Provision of written informed consent by the patient or a legal representative prior to enrollment\n\nExclusion Criteria:\n\n* Pre-existing or concomitant upper extremity dysfunction unrelated to the rotator cuff tear, including cervical disc herniation, cerebrovascular accident (stroke), traumatic brain injury, cervical spinal cord injury, rheumatoid arthritis with shoulder involvement, or brachial plexus injury.\n* Complex or irreparable rotator cuff tears, defined as large or massive tears (\\> 5 cm), high-grade fatty infiltration of the rotator cuff muscles (Goutallier grade ≥ 3), or inability to achieve secure tendon repair using sutures during arthroscopic surgery.\n* Postoperative complications that significantly interfere with rehabilitation, such as surgical site infection, nerve injury with paralysis, or severe deltoid muscle damage.\n* Severe comorbidities that may substantially affect the rehabilitation process or patient safety, including acute coronary syndrome, recent stroke, uncontrolled diabetes mellitus, or other debilitating systemic diseases.\n* Inability or unwillingness to comply with the study protocol, including failure to attend scheduled follow-up assessments or voluntary withdrawal from the study.",{"count":287,"type":20},102,[127],"The aim of this study was to evaluate the effectiveness of a mobile application for telemedicine in patients recovering from arthroscopic rotator cuff tendon repair. Participants were randomly assigned to one of two groups: a test group using a mobile application for exercise guidance and monitoring, or a control group receiving standard paper-based exercise instructions. The study aimed to compare the effectiveness of rehabilitation, treatment adherence, cost savings, and patient satisfaction between the two methods over a 6-month follow-up period.",[182,291,27],"Telemedecine",[26,27,293,294,295,296],"Telerehabilitation","Mobile Application","Digital Health","Arthroscopic Rotator Cuff Repair","2026-04-21",{"date":299,"type":33},"2026-04-29",{"date":301,"type":20},"2026-04-14",{"date":303,"type":20},"2027-12-31",{"name":305,"class":82},"Hanoi Medical University",{"id":307,"slug":4,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":313,"targetDuration":4,"studyType":21,"phases":315,"briefSummary":316,"conditions":317,"keywords":319,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":83},"100545429","NCT06381791","CBD for Pain Following Orthopedic Shoulder Surgery","Cannabidiol (CBD) As A Pain Adjunct in Orthopedic Surgical Patients: A Randomized Control Trial","CBD","Inclusion Criteria:\n\n* Above the age of 18 years old\n* Undergoing a rotator cuff repair surgery\n* Receiving standard anesthesia during surgery\n* If a subject is of reproductive potential, they must be on effective contraception one month prior, during treatment, and one month following treatment.\n\nExclusion Criteria:\n\n* Under the age of 18 years old\n* History of revision shoulder arthroplasty\n* History of liver disease or impairment\n* Are currently taking valproate or clobazam\n* Are currently taking a moderate\u002Fstrong CYP3A4 or CYP2C19 inhibitor\n* Are currently taking a strong CYP3A4 or CYP2C19 inducer\n* Are currently taking narcotics\n* History of substance\u002Falcohol abuse\n* Those currently or previously under the care of a pain management specialist\n* History of marijuana\u002Fcannabidiol (not including topical) regular use within the past 6 months\n* Allergy related to cannabidiol\n* Allergy related to sesame seeds\n* Pregnancy (As part of standard of care, all female participants will be administered a urine pregnancy test prior to surgery. A negative test result is required to participate in the study.)\n* If you are taking any medications with known risks for suicidal behavior and ideation\n* If you have a diagnosed psychiatric disorder\n* If you are untreated for a diagnosed sleeping disorder\n* If you are actively breastfeeding\n* Patients currently taking central nervous system (CNS) depressants\n* Patients currently taking other drugs with known hepatotoxicity\n* Vulnerable populations.\n\nPatients taking concomitant medications which are substrate of uridine 5'-diphospho-glucuronosyltransferase 1-9 (UGT1A9), uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and P-gp will be monitored for potential adverse events based on the Epidiolex® label for the concomitant medication being used.",{"count":314,"type":20},80,[151,152],"The goal of the study is to learn if Epidiolex (cannabidiol) works as a additional pain medication in patients who have had orthopedic shoulder surgery. It is also to learn about safe dosages and identify any side effects after surgery.\n\nResearchers will compare Epidiolex to a placebo solution to see if Epidiolex lowers pain after shoulder surgery.\n\nParticipants will:\n\n* track their pain and what medications they use every day in a provided pain diary. A researchers will call every seven days to check on the participant and diary.\n* Complete two short surveys. Once before surgery and once after.\n* Have bloodwork tested after surgery",[318,27],"Shoulder Osteoarthritis",[311,320,321],"Cannabidiol","Epidiolex","2026-04-15",{"date":324,"type":33},"2026-04-16",{"date":326,"type":33},"2024-05-24",{"date":328,"type":20},"2027-12-30",{"name":330,"class":82},"The Methodist Hospital Research Institute",{"id":332,"slug":4,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":15,"minAge":338,"maxAge":261,"enrollmentInfo":339,"targetDuration":341,"studyType":95,"phases":4,"briefSummary":342,"conditions":343,"keywords":349,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":358,"leadSponsor":360,"locationsCount":83},"100631464","NCT07501013","Clinical Outcomes of Arthroscopic Surgeries for Shoulder and Knee Sports Injuries","Clinical Outcomes and Associated Factors Following Arthroscopic Surgeries for Shoulder and Knee Sports Injuries: A Prospective Cohort Study","SK-COHORT","Inclusion Criteria:\n\n* Age \\>= 8 years.\n* No gender restrictions.\n* Definitive diagnosis of shoulder or knee sports injuries or related joint conditions.\n* Scheduled to undergo elective, standard-of-care surgery at the study center (procedures include but are not limited to: arthroscopic meniscus repair\u002Fmeniscectomy, cartilage repair, cruciate ligament reconstruction, high tibial osteotomy \\[HTO\\], unicompartmental knee arthroplasty \\[UKA\\], arthroscopic rotator cuff repair, shoulder stabilization, and shoulder arthroplasty).\n* Clear consciousness, with the ability to read, understand, and communicate.\n* Willing and able to comply with postoperative follow-up requirements.\n* Voluntarily signed the written informed consent form.\n\nExclusion Criteria:\n\n* Patients requiring emergency surgery due to acute, severe trauma (e.g., open fractures, polytrauma).\n* Coexisting severe neurological or psychiatric diseases, or cognitive impairment that prevents understanding of the informed consent or cooperation with follow-up.\n* Patients in an involuntary state (e.g., under coercion).\n* Refusal to sign the informed consent form or refusal to participate in the study.\n* Currently participating in other interventional clinical trials that may confound or affect the clinical outcomes of this study.","8 Years",{"count":340,"type":20},500,"2 Years","This observational study aims to evaluate the long-term recovery and clinical outcomes of patients undergoing minimally invasive (arthroscopic) surgeries for sports-related shoulder and knee injuries.\n\nSports injuries, such as ligament tears, meniscus damage, and rotator cuff tears, are common and can significantly impact a person's daily life and ability to return to sports. While surgery is an effective treatment, the recovery process and final outcomes can vary greatly from person to person.\n\nResearchers will follow patients who are already scheduled for routine shoulder or knee surgery at the study center. By collecting detailed information about the patient's initial injury, the specific surgical techniques used by the doctor, and the patient's recovery progress over two years, the study hopes to identify which factors lead to the best healing and functional outcomes.\n\nParticipants will be asked to complete standard questionnaires about their joint function and pain levels before their surgery, and again at 6 months, 1 year, and 2 years after surgery. The study is strictly observational; it will not change the standard medical care, surgical plan, or rehabilitation routine the patients receive.",[344,27,345,346,347,348],"Athletic Injuries (C26.857.500.124)","Tibial Meniscus Injuries","Shoulder Dislocation or Subluxation","Anterior Cruciate Ligament Injuries","Posterior Cruciate Ligament Tear",[106,350,351,352,353],"Sports Medicine","Patient Reported Outcome Measures","Prospective Cohort","Clinical Outcomes","2026-04-07",{"date":356,"type":33},"2026-04-13",{"date":354,"type":33},{"date":359,"type":20},"2046-04-07",{"name":361,"class":82},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":363,"slug":4,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":368,"targetDuration":4,"studyType":21,"phases":370,"briefSummary":371,"conditions":372,"keywords":373,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":83},"100633331","NCT07525297","Mulligan's Mobilization in Rotator Cuff Pathology","The Effect of Adding Thoracic Mobilization to Mulligan's Mobilization With Movement in Individuals With Rotator Cuff Pathology","Inclusion Criteria:\n\n* Having been diagnosed with unilateral rotator cuff pathology (impingement syndrome, tendinopathy, or partial tear) by a specialist physician through clinical examination and\u002For radiological imaging (USG\u002FMR);\n* Being between 18 and 65 years of age;\n* Having shoulder pain that has persisted for at least 3 months;\n* Having a positive result on at least two of the Neer, Hawkins-Kennedy, and Empty Can tests;\n* Having a pain intensity of at least 3\u002F10 on the Pain Numerical Rating Scale (NPRS) during rest or activity;\n* Having sufficient cognitive ability to follow simple instructions and administer the tests;\n* Having a Mini Mental State Test score ≥24;\n* Having the ability to provide signed informed consent and agreeing to participate in the study voluntarily.\n\nExclusion Criteria:\n\n* Having undergone previous surgery on the shoulder or thoracic region;\n* Having full-thickness rotator cuff tears requiring surgical indication;\n* Having adhesive capsulitis, shoulder instability, labrum tears, or calcific tendinitis;\n* Having cervical radiculopathy or neurological diseases affecting the upper extremity;\n* Having uncontrolled diabetes, inflammatory rheumatic diseases (rheumatoid arthritis, etc.), or malignancy;\n* Having severe osteoporosis, unstable vertebral fractures, or active infection in the thoracic region;\n\nhaving received steroid (cortisone) or PRP injections to the shoulder region within the last 3 months.",{"count":369,"type":20},40,[127],"Rotator cuff pathology is defined as the degeneration or tear of one or more of the muscles or tendons of the rotator cuff, namely the supraspinatus, infraspinatus, teres minor, and subscapularis. Shoulder girdle biomechanics are not solely comprised of the glenohumeral joint but are built upon a kinetic chain involving the synchronized movement of the scapula, clavicle, and thoracic spine. In this context, the concept described in the literature as the \"Regional Dependence\" model argues that functional impairment in a distal segment like the shoulder may stem from or exacerbate limitations in a more proximal region like the thoracic spine. Conventional treatment approaches that focus solely on the shoulder joint may have limited clinical outcomes due to neglecting the fundamental link in the kinetic chain. Maintained natural apophyseal glides (SNAGs), a cornerstone of Mulligan's Concept in spinal rehabilitation, are a dynamic manual therapy technique aimed at correcting microscopic misalignments in facet joints during active movement. The aim of this randomized controlled trial is to investigate the effects of thoracic mobilization added to the Mulligan movement shoulder mobilization technique on pain intensity, range of motion, proprioception, and upper extremity functionality in individuals with rotator cuff pathology, and to evaluate the superiority of this combined approach over shoulder mobilization alone. Assessments will be performed before treatment and at the end of the 3-week intervention. Rest and activity pain intensity will be assessed using the Pain Numerical Rating Scale (PMR), shoulder range of motion using a digital goniometer, thoracic kyphosis degrees using a smartphone with the 'Angle Meter' software installed and calibrated gyroscope and accelerometer sensors, functionality using the Shoulder Pain and Disability Index (SPAI), and proprioception using a laser pointer and target device. The obtained data will be compared using appropriate statistical analysis methods. This study is expected to provide scientific evidence regarding the clinical effectiveness of thoracic mobilization technique added to shoulder mobilization technique applied in conjunction with conventional treatment in individuals with rotator cuff pathology, and to contribute to filling the methodological gap mentioned in the literature.",[27],[374,375,376,377,378],"Rotator cuff injuries","Manual therapy","Exercise","Shoulder joint","Thoracic Vertebrae","2026-04-06",{"date":356,"type":33},{"date":382,"type":20},"2026-04-20",{"date":384,"type":20},"2026-10-20",{"name":386,"class":82},"Yuzuncu Yil University",{"id":388,"slug":4,"hasResults":11,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":392,"eligibilityCriteria":393,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":394,"enrollmentInfo":395,"targetDuration":4,"studyType":21,"phases":397,"briefSummary":398,"conditions":399,"keywords":402,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":413,"leadSponsor":415,"locationsCount":83},"100625856","NCT07428070","Contextually Enriched Individualized Exercise Versus Contextually Fixed Exercise for Rotator Cuff-Related Shoulder Pain","Comparison of the Effectiveness of Contextually Enriched Exercise Programs in Rotator Cuff-related Shoulder Pain","CONTEXT-RCRSP","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Clinical diagnosis of rotator cuff-related shoulder pain\n* Shoulder pain duration longer than 3 months\n* Painful arc during shoulder flexion or abduction\n* Positive Neer or Hawkins-Kennedy test\n* Pain during resisted external rotation or abduction, or positive Jobe test\n* Ability to understand and speak Turkish\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Clinical signs of a large rotator cuff tear characterized by marked weakness without pain\n* Other shoulder conditions (e.g., frozen shoulder defined as at least 30 percent passive glenohumeral restriction in two or more directions, advanced osteoarthritis, fracture, dislocation, or severe acromioclavicular joint pathology)\n* Previous shoulder surgery\n* Neurological disorders or significant systemic diseases such as rheumatoid arthritis\n* Current or past history of malignancy\n* Physical or cognitive impairments preventing participation in assessments or intervention sessions\n* Reproduction of shoulder symptoms with active cervical spine movements indicating symptomatic cervical pathology\n* Corticosteroid injection within the previous 6 weeks\n* Participation in other concurrent shoulder treatments during the study","75 Years",{"count":396,"type":20},72,[127],"The goal of this clinical trial is to learn whether adding personalized contextual factors to an exercise program can improve pain and function in people with rotator cuff-related shoulder pain. This condition is a common cause of shoulder pain and can limit daily activities.\n\nThe main questions this study aims to answer are:\n\n1. Does a contextually enriched and individualized exercise program lead to greater improvement in upper-limb disability (measured by the QuickDASH questionnaire) compared with a contextually fixed program?\n2. Does it lead to greater reductions in pain intensity (measured by the Numeric Pain Rating Scale) and greater improvements in autonomic nervous system regulation (measured by heart rate variability)?\n3. Does it result in more favorable changes in psychosocial outcomes, exercise adherence, and therapeutic alliance?\n\nResearchers will compare two exercise programs to determine whether adding personalized contextual features enhances treatment effectiveness.\n\nOne group will receive a standardized, evidence-based exercise program delivered in a fixed and neutral manner.\n\nThe other group will receive the same exercise program with added personalized contextual elements, such as:\n\n* Preferred music and lighting\n* Choice between equivalent exercises (without changing exercise type or dosage)\n* Motivational feedback and supportive communication\n* Personalized progress tracking\n\nBoth groups will:\n\n* Attend supervised exercise sessions twice per week for 12 weeks\n* Follow a structured home exercise program\n* Complete questionnaires assessing pain, function, and psychological factors\n* Undergo heart rate variability assessment to evaluate autonomic regulation\n* Be followed for 12 months after treatment\n\nThe researchers expect that integrating personalized contextual elements into exercise therapy may enhance recovery, increase motivation, and improve long-term outcomes.",[400,401,27],"Rotator Cuff Related Shoulder Pain","Shoulder Pain",[27,401,403,404,405,406,407,408,409],"Contextual Healing","Placebo Effect","Exercise Therapy","Therapeutic Alliance","Treatment Adherence","Pain Catastrophizing","Kinesiophobia",{"date":411,"type":33},"2026-04-09",{"date":272,"type":20},{"date":414,"type":20},"2028-05-06",{"name":416,"class":82},"Istanbul Nisantasi University",{"id":418,"slug":4,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":424,"minAge":425,"maxAge":261,"enrollmentInfo":426,"targetDuration":4,"studyType":21,"phases":428,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":4},"100540558","NCT06318403","Estradiol Supplementation and Rotator Cuff Repair","Estradiol Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial","ESTRCR","Inclusion Criteria\n\n1. A plan for a primary rotator cuff repair\n2. Female sex (assigned sex at birth)\n3. \\>1 cm tear width, full thickness supraspinatus\u002Finfraspinatus tear\n4. Post-menopausal, as defined by at least twelve months since last menses\n5. Age 50-80\n\nExclusion Criteria\n\n1. Active infection\n2. Baseline serum estradiol \\>20 pg\u002FmL\n3. Infraspinatus or supraspinatus muscle atrophy of greater than or equal to Goutallier grade 3\n4. Pre-operative systemic estradiol supplementation\n5. Medically unfit for operative intervention\n6. Revision surgery\n7. Unwillingness to participate in the study, including post-operative imaging\n8. Inability to read or comprehend written instructions\n9. Prisoner\n10. Concomitant patch augmentation or tendon-transfer\n11. Breast cancer or a history of breast cancer or other estradiol-dependent neoplasia\n12. Liver disease as documented in the medical record\n13. Active venous thromboembolic disease, such as deep venous thrombosis, pulmonary embolism, a history of these conditions, or a known predisposition to these disorders (such as Protein C, protein S, or antithrombin deficiency)\n14. Active arterial thromboembolic disease, such as stroke, myocardiac infarction, a history of these conditions, or a known predisposition to these disorders\n15. Isolated subscapularis tears\n16. Known anaphylactic reaction or hypersensitivity to estradiol, adhesive, or transdermal patches","FEMALE","50 Years",{"count":427,"type":20},58,[152],"Rotator cuff tears in the shoulder are common causes of pain and disability, often fail to heal with surgery, and tears, worse outcomes after surgery, and failure of healing are associated with estradiol deficiency. In this study, post-menopausal women will be randomized to either estradiol patches or placebo patches after repair of the rotator cuff. The purpose of this study is to determine whether estradiol patches show promise in improving shoulder pain, strength, muscle volumes, and function when given with rotator cuff repair.",[26,27,431,432,433],"Rotator Cuff Syndrome","Menopause Related Conditions","Menopause","2026-03-17",{"date":436,"type":33},"2026-03-19",{"date":438,"type":20},"2028-03",{"date":440,"type":20},"2030-12",{"name":442,"class":82},"University of Utah",{"id":444,"slug":4,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":21,"phases":451,"briefSummary":452,"conditions":453,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":83},"100623120","NCT07392502","Telerehabilitation for Shoulder Surgery Recovery","Telerehabilitation for Shoulder Surgery Recovery: A Randomized Trial Assessing the Effectiveness of the Band Connect Platform","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for primary arthroscopic rotator cuff repair Surgery to be performed by Dr. Young Kwon, Dr. Mandeep Virk, Dr. Dennis DeBernardis, or Dr. Jie Yao\n* Planning to complete postoperative physical therapy at selected NYU physical therapy locations\n* Access to home internet and a wireless cell phone compatible with the Band Connect App\n\nExclusion Criteria:\n\n* Patients undergoing revision RCR\n* Patients whose post operative rehabilitation has to be delayed or modified.\n* Pregnant individuals\n* Shoulder injuries related to workers compensation or involved in any pending litigation\n* Patients unable to provide informed consent",{"count":450,"type":20},68,[127],"This study aims to evaluate the effectiveness of a telerehabilitation protocol utilizing the Band Connect platform in patient recovery following rotator cuff repair surgery. This will be a randomized control trial with patients assigned into a traditional rehabilitation or a telerehabilitation protocol.",[27],"2026-01-30",{"date":456,"type":33},"2026-02-06",{"date":458,"type":20},"2026-03-01",{"date":460,"type":20},"2028-12-31",{"name":462,"class":82},"NYU Langone Health",{"id":464,"slug":4,"hasResults":11,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":92,"enrollmentInfo":469,"targetDuration":4,"studyType":21,"phases":470,"briefSummary":471,"conditions":472,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":476,"startDateStruct":478,"completionDateStruct":480,"leadSponsor":482,"locationsCount":83},"100433388","NCT04923477","Therapeutic Exercise for Rotator Cuff Tendinopathy \u002F Subacromial Pain Syndrome - Outcomes and Mechanisms","Mechanisms of Exercise for Rotator Cuff Tendinopathy \u002F Subacromial Pain Syndrome","Inclusion Criteria:\n\n1. the clinical diagnosis for RC tendinopathy will be made with positive 3 of 5 tests: Hawkins-Kennedy, Neer, painful arc, empty can, external rotation resistance test\n2. pain ≥ 3\u002F10 on a numeric pain rating scale\n3. age: 18 - 45 years\n4. Participant must read, sign and date the appropriate Informed consent document.\n5. Participant BMI ≤ 30\n\nExclusion Criteria:\n\n1. Insufficient ability to comprehend and complete the questionnaires,\n2. Inability to attend sessions,\n3. Prior surgery of shoulder, neck or thoracic spine,\n4. Primary complaint of neck or thoracic pain,\n5. Diagnosis of cervical spinal stenosis,\n6. Any serious spinal and shoulder pathology: infections, arthrosis, rheumatic disorders, acute fractures, shoulder dislocation, osteoporosis, or tumors,\n7. Central Nervous System involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman and\u002For Babinski reflexes,\n8. two or more neurologic signs of nerve root compression to include myotomal weakness, positive muscle stretch reflex, and dermatomal sensory loss,\n9. any shoulder or arm pain with cervical spine tests of Spurling's Test, cervical rotation to the ipsilateral side, or axial compression test, or\n10. primary adhesive capsulitis defined by passive range of motion loss \\>50% as compared bilaterally of shoulder external rotation, internal rotation, or elevation.\n11. Has a device or other condition that is not safe for MRI, including pacemakers.",{"count":231,"type":20},[127],"Rotator cuff tendinopathy, one of the pathologies identified as part of the cluster of shoulder symptoms known as subacromial pain syndrome, is a common musculoskeletal shoulder condition. Resolution of pain and disability is poor despite treatment, with only about 50% reporting full recovery at 12 - 18 months. Prior studies suggest therapeutic exercise when used alone and with other interventions can have positive outcomes; however, not all patients with rotator cuff tendinopathy respond. Few studies have assessed the effects of exercise for individuals with chronic pain, especially brain driven mechanisms, thought to play a key role. In this study, we will use brain imaging to understand the mechanisms, identify predictors of a positive response to exercise, and the relationship to biomechanical and pain-related factors in patients with RC tendinopathy. The findings from this study will optimize the delivery and treatment response to exercise for individuals with shoulder pain.",[473,474,27,475],"Rotator Cuff Tendinosis","Rotator Cuff Tendinitis","Subacromial Pain Syndrome",{"date":477,"type":33},"2026-02-03",{"date":479,"type":33},"2021-06-08",{"date":481,"type":20},"2026-12-31",{"name":483,"class":82},"University of Southern California",{"id":485,"slug":4,"hasResults":11,"nctId":486,"briefTitle":487,"officialTitle":487,"acronym":488,"eligibilityCriteria":489,"healthyVolunteers":91,"sex":15,"minAge":16,"maxAge":490,"enrollmentInfo":491,"targetDuration":4,"studyType":21,"phases":492,"briefSummary":493,"conditions":494,"keywords":496,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":83},"100446628","NCT05095909","Utility of Intermittent Cryo-Compression Versus Traditional Icing Following Arthroscopic Rotator Cuff Repair","ICC","Inclusion Criteria:\n\n1. Patients who are candidates for arthroscopic rotator cuff repair\n\n   1. Acute, traumatic tear of the rotator cuff in an active patient\n   2. Chronic, symptomatic tear of the rotator cuff in an active patient having failed non - operative treatment\n2. Patient agreeable to participation in the study and able to complete informed consent process and all study requirements.\n3. ≥18 years of age\n\nExclusion Criteria:\n\n1. Pregnancy (per pre-operative physical)\n2. Presence of significant glenohumeral joint osteoarthritis\n3. Age over 70\n4. History of clinically diagnosed lymphedema\n5. Morbid obesity (BMI \\> 45)\n6. History of drug or alcohol addiction, prior opioid dependence, or current use of opioid medication (preoperative)\n7. Investigators concern regarding subject's ability or willingness to follow protocol.\n8. History of significant vascular impairment in the affected region (e.g., from prior frostbite, diabetes, arteriosclerosis or ischemia).\n9. History of acute paroxysmal cold hemoglobinuria or cryoglobulinemia.\n10. History of Raynaud's disease or cold hypersensitivity (cold urticarial).","70 Years",{"count":19,"type":20},[127],"Effective post - operative pain control following orthopedic surgical procedures without excessive reliance upon opioid pain medication has garnered increased attention in recent years. This study will evaluate the utilization of a non-invasive, novel cryo - compression, post-operative modality to improve pain control versus standard ice wraps in the immediate post-operative phase of arthroscopic rotator cuff surgery via a randomized controlled study design. Furthermore, if this study demonstrates improved pain control, improved quality of life and decreased opioid usage with the intermittent cold compression unit, recommendations may be considered for system-wide utilization.",[27,495],"Cryotherapy Effect",[497,67],"Cryo-compression","2026-01-26",{"date":500,"type":33},"2026-01-27",{"date":502,"type":33},"2024-08-05",{"date":504,"type":20},"2026-12",{"name":506,"class":82},"Allina Health System",{"id":508,"slug":4,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":11,"sex":15,"minAge":513,"maxAge":490,"enrollmentInfo":514,"targetDuration":4,"studyType":21,"phases":516,"briefSummary":517,"conditions":518,"keywords":521,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":531,"locationsCount":4},"100621561","NCT07372222","Effect of a Posterior Shoulder Pillow on Pain and Sleep Quality After Rotator Cuff Repair","Effect of a Posterior Shoulder Pillow on Pain and Sleep Quality After Rotator Cuff Repair: A Prospective Cohort Study","Inclusion Criteria:\n\n* Diagnosis of a rotator cuff tear, confirmed by imaging (MRI or ultrasound), and deemed suitable for either single-row or double-row arthroscopic repair surgery.\n* Age between 40 and 70 years.\n* Willing and able to provide written informed consent to participate in the study.\n* Demonstrates good compliance with postoperative rehabilitation and follow-up requirements.\n\nExclusion Criteria:\n\n* Presence of concomitant shoulder pathologies, such as glenohumeral osteoarthritis, adhesive capsulitis, history of labral repair, or irreparable tendon tears.\n* Pre-existing severe shoulder infection, tumor, or other conditions that may significantly impact postoperative recovery.\n* Previous history of shoulder surgery or severe shoulder deformity that could confound the assessment of postoperative outcomes.\n* Cognitive impairment or inability to understand the pain assessment tools (e.g., VAS score).\n* Significant comorbidities affecting the heart, liver, or kidneys, or requiring long-term use of medications that affect coagulation (e.g., aspirin).\n* Diagnosis of malignant tumors or rheumatic autoimmune diseases that may interfere with postoperative recovery.\n* MRI findings indicating significant fatty infiltration (\\>50%) or tendon retraction, suggesting potential compromise in surgical outcome and recovery.\n* Superior migration of the humeral head or obliteration of the coracoacromial space, indicating a high difficulty of rotator cuff repair.\n* Contraindications to postoperative rehabilitation exercises, such as severe osteoporosis or neuromuscular diseases.","40 Years",{"count":515,"type":20},126,[127],"The goal of this clinical study is to learn if using a special pillow placed behind the shoulder can help to reduce pain and improve sleep for patients after surgery to repair a torn rotator cuff. The main questions it aims to answer are:\n\n* Do patients who choose to use the posterior shoulder pillow have lower pain levels after surgery?\n* Do these patients report better sleep quality during recovery?\n* How safe and comfortable is the pillow for patients to use? Researchers will compare patients who use the pillow to those who do not use it to see if there is a difference in their recovery.\n\nParticipants will:\n\n* Be asked about their willingness to use the pillow. Their treatment and recovery plan will be decided together with their doctor.\n* Be asked to rate their pain and sleep quality several times after surgery: at 1 week, 2 weeks, 4 weeks, and 6 weeks.\n* Have their shoulder function assessed by a clinician at 2, 4, and 6 weeks after surgery.\n* Receive a standard MRI scan before and 6 weeks after surgery as part of their regular medical care to check on healing.",[27,519,520],"Postoperative Pain","Sleep Quality",[522,181,519,520,523],"Pillows","Randomized Controlled Trial","2026-01-19",{"date":526,"type":33},"2026-01-28",{"date":528,"type":20},"2026-02-15",{"date":530,"type":20},"2027-12-15",{"name":532,"class":82},"Peking University Third Hospital",{"id":534,"slug":4,"hasResults":11,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":21,"phases":542,"briefSummary":543,"conditions":544,"keywords":545,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":557},"100473405","NCT05444465","Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears","Evaluation of Safety and Efficacy of a Resorbable Collagen Implant in Treatment of High Grade PArtial ThiCkness Tears; A Prospective, Multicenter, Randomized, Control Trial (IMPACT Study)","IMPACT","Inclusion Criteria:\n\n* The subject must provide written informed consent.\n* Subject is \\> eighteen (18) years of age (no upper limit).\n* Subject has an isolated high-grade (\\>50% or \\>6mm) (Ellman grade III) partial thickness tear of supraspinatus or supraspinatus with infraspinatus.\n* Subject has failed a minimum of 3 months of conservative management for treatment of partial thickness rotator cuff tear.\n* Subject willing and able to make all required study visits.\n* Subject able to follow instructions and deemed capable of completing all study questionnaires.\n\nExclusion Criteria:\n\n* Subjects with insufficient tendon tissue quality for management and protection of the tendon injury using the isolated REGENETEN Bioinductive Implant system.\n* Subjects where the prescribed Physical Therapy guidelines stated in the protocol are not suitable for their rehabilitation.\n* Subjects with Samilson-Prieto osteoarthritis grade 2 and greater.\n* Subjects with current or prior infection of the ipsilateral shoulder.\n* Subjects with known hypersensitivity to bovine-derived materials.\n* Subjects with known inflammatory arthropathy, history of inflammatory arthropathy, chronic joint disease or chronic pain of upper extremities (shoulder(s), arm(s)).\n* Subjects with prior shoulder surgery on index shoulder, including subacromial decompression, biceps tenodesis\u002Ftenotomy, and acromioclavicular joint (ACJ) excision\u002Fdistal clavicle excision (DCE).\n* Subjects with a planned surgery on the contra-lateral shoulder within the study period.\n* Systemic steroid use (oral, IV) or local steroid injection within 3 months of the date of surgery.\n* Subjects with a full thickness rotator cuff tear.\n* Subjects with a subscapularis tear requiring repair.\n* Subjects requiring a concomitant labral fixation procedure, concomitant surgery for bone defects requiring bone implantation or for superior labral tear from anterior to posterior (SLAP).\n* Subjects requiring a concomitant os acromiale fixation procedure.\n* Subjects with glenohumeral joint instability (multiple dislocations\u002Fsubluxations).\n* Subjects with condition(s) that contraindicate or complicate outcomes of Isolated Bioinductive Repair or completion and repair e.g., \\> Hamada 3 rotator cuff arthropathy on X-ray, Goutallier atrophy \\> Grade 3, proximal humeral fracture or scapular fracture, avascular necrosis of the humeral head.\n* Subjects with neurologic conditions effecting either upper extremity.\n* Subjects who are unable to tolerate magnetic resonance imaging (MRI), due to psychiatric or medical contraindications.\n* Subjects who are pregnant or breast feeding.\n* Subjects who are currently involved in any injury litigation relating to the index shoulder.\n* Subjects with current workers compensation claim.\n* Subjects who are enrolled, or plan to enroll, in another clinical trial during this study that would affect the outcomes of this study.\n* Subjects with a history of poor compliance with medical treatment, physical therapy (PT)\u002Frehabilitation, or clinical study participation.\n* Subject who, in the opinion of the Investigator, has an emotional or neurological condition that would pre-empt their ability or willingness to participate in the study including mental illness, mental retardation, and drug or alcohol abuse.\n* Subjects who do not meet the indication or are contraindicated according to specific Smith+Nephew REGENETEN System's Instructions for Use (IFUs).\n* Any subject that meets the definition of a Vulnerable Subject per ISO 14155 Section 3.55.\n* Subjects who have participated previously in this clinical trial and who have healed or been withdrawn\n* Subjects with a medical or physical condition that, in the opinion of the Investigator, would preclude safe subject participation in the study.",{"count":541,"type":20},234,[127],"The purpose of the study is to assess whether the REGENETEN™ Bioinductive Implant allows patients to get back to their everyday activities quicker than if the tendon is repaired by the standard repair technique 'Completion and Repair' for surgically treating partial-thickness rotator cuff tears.",[27],[546,547,548],"Rotator cuff tear","High grade partial thickness tears","REGENETEN Bioinductive Implant System","2026-01-14",{"date":551,"type":33},"2026-01-15",{"date":553,"type":33},"2022-08-30",{"date":555,"type":20},"2028-06-30",{"name":195,"class":196},20,{"id":559,"slug":4,"hasResults":11,"nctId":560,"briefTitle":561,"officialTitle":561,"acronym":562,"eligibilityCriteria":563,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":490,"enrollmentInfo":564,"targetDuration":4,"studyType":21,"phases":566,"briefSummary":567,"conditions":568,"keywords":570,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":83},"100619699","NCT07348016","Safety and Efficacy of Platelet-Rich Plasma Combined With Compound Betamethasone in Arthroscopic Surgery for Rotator Cuff Injury With Shoulder Adhesion: A Prospective, Multicenter, Randomized Controlled Trial","PRP+CB for RC","Inclusion Criteria:\n\nAge between 18 and 70 years.\n\nClinical and MRI diagnosis of full-thickness rotator cuff tear.\n\nPresence of shoulder stiffness\u002Fadhesion defined as passive range of motion less than 100° in forward flexion and\u002For less than 10° in external rotation (or according to your specific definition).\n\nScheduled for arthroscopic rotator cuff repair and capsular release.\n\nWilling and able to provide written informed consent.\n\nWilling to comply with all study procedures and follow-up visits.\n\nExclusion Criteria :\n\nMassive, irreparable rotator cuff tear.\n\nSevere glenohumeral osteoarthritis (Grade III or IV according to Samilson-Prieto classification).\n\nHistory of shoulder infection, fracture, or previous surgery on the affected shoulder.\n\nKnown allergy or contraindication to betamethasone, local anesthetics, or components of PRP preparation.\n\nSystemic inflammatory arthritis (e.g., rheumatoid arthritis).\n\nCoagulation disorders or use of anticoagulants that cannot be safely suspended perioperatively.\n\nPregnancy or lactation.\n\nParticipation in another clinical trial within the past 3 months.\n\nAny medical or psychiatric condition that, in the investigator's opinion, would compromise patient safety or compliance with the study protocol.",{"count":565,"type":20},70,[127],"Background: Patients undergoing arthroscopic surgery for rotator cuff tears with shoulder adhesion often experience significant postoperative pain and stiffness. This study investigates whether adding a long-acting local anesthetic (Liposomal Bupivacaine) to a standard anti-inflammatory steroid injection (Compound Betamethasone) during surgery can improve outcomes.\n\nMethods: This is a prospective, randomized, double-blind, controlled trial. Approximately 70 eligible adult patients will be randomly assigned to one of two groups: (1) the Combination Group, receiving an intra-articular injection of Liposomal Bupivacaine plus Compound Betamethasone after surgery, or (2) the Control Group, receiving Compound Betamethasone alone. Patients and outcome assessors will not know the group assignment.\n\nWhat participants will do: All participants will receive standard arthroscopic rotator cuff repair and adhesion release. They will be followed for 12 months after surgery, with assessments at multiple time points (from hours to months post-op) to measure pain levels, shoulder function, range of motion, and tendon healing via MRI.\n\nMain Goals: The primary goal is to compare the improvement in UCLA shoulder scores between the two groups at 12 months. Secondary goals include comparing pain scores, other functional scores (Constant-Murley), joint mobility, MRI findings, and safety (complication rates).",[27,569],"Adhesions",[571,572,106,523,573,574],"Platelet-Rich Plasma","Compound Betamethasone","Shoulder","Stiffness","2026-01-08",{"date":577,"type":33},"2026-01-16",{"date":579,"type":33},"2025-08-01",{"date":581,"type":20},"2028-12-01",{"name":583,"class":82},"Second Affiliated Hospital of Nanchang University",{"id":585,"slug":4,"hasResults":11,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":11,"sex":15,"minAge":513,"maxAge":490,"enrollmentInfo":590,"targetDuration":4,"studyType":21,"phases":592,"briefSummary":593,"conditions":594,"keywords":595,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":608},"100573279","NCT06744218","Effectiveness of Telerehabilitation as an Alternative to Outpatient Physiotherapy in the 1 Month After Arthroscopic Rotator Cuff Repair Surgery","Effectiveness of Telerehabilitation as an Alternative to Outpatient Physiotherapy in the 1 Month After Arthroscopic Rotator Cuff Repair Surgery: Multicenter Randomized Clinical Trial","Inclusion Criteria:\n\n* Male or female patients aged between 40 and 70 years\n* Patients undergoing arthroscopic repair surgery of the rotator cuff tendons\n* Start of outpatient treatment within 7 days of discharge from the Orthopedic Department of the Argenta and Delta hospitals\n* Continuation of rehabilitation care at the IOR Physical and Rehabilitation Medicine service in Argenta or at the Physical Therapy Rehabilitation Medicine service of the Delta Hospital.\n* Patients who have provided informed consent\n\nExclusion Criteria:\n\n* Previous shoulder surgeries\n* difficulty understanding the Italian language\u002Flanguage barrier\n* unavailability of IT devices or stable wi-fi connection by the patient",{"count":591,"type":20},46,[127],"The present study aims to verify whether telerehabilitation as an alternative to in-person treatment (both conducted by a physiotherapist) can be a valid option in terms of pain, recovery of the rom, shoulder functionality compared to those provided by therapy alone. face-to-face rehabilitation in patients undergoing arthroscopic rotator cuff repair surgery.",[27],[596,597,598],"telerehabilitation","physiotherapist","rotator cuff repair surgery","2025-12-19",{"date":601,"type":33},"2025-12-26",{"date":603,"type":33},"2024-11-22",{"date":605,"type":20},"2026-11",{"name":607,"class":82},"Istituto Ortopedico Rizzoli",2,{"id":610,"slug":4,"hasResults":11,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":4,"eligibilityCriteria":614,"healthyVolunteers":91,"sex":15,"minAge":16,"maxAge":615,"enrollmentInfo":616,"targetDuration":4,"studyType":21,"phases":618,"briefSummary":619,"conditions":620,"keywords":621,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":623,"lastUpdatePostDateStruct":624,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":608},"100615229","NCT07289893","Investigation of the Effects of Kettlebell Training","Investigation of the Effects of Kettlebell Training on Pain, Function and Performance in Rotator Cuff-Related Shoulder Pain; Randomized Controlled Trial.","Inclusion Criteria:\n\n* Individuals who are willing to participate and have been doing licensed\u002Funlicensed amateur or professional sports for at least 3 years,\n* Individuals with Tegner Activity Scale ≥ 5,\n* A history of shoulder pain of at least 6 weeks,\n* At least 3 points measured using the 0 to 10 point Numerical Pain Scale (NPS),\n* Shoulder pain that worsens with resisted shoulder flexion, abduction or external rotation,\n* Rotator cuff tendinopathies,\n* Tears smaller than 1 cm,\n* Secondary shoulder instability without major trauma (due to rotator cuff muscle weakness, etc.)\n\nExclusion Criteria:\n\n* History of fracture and\u002For surgery in the shoulder area,\n* Adhesive capsulitis,\n* Those with passive joint range of motion deficit,\n* Individuals with a positive Apprehension Test and\u002For Sulcus Sign test and multidirectional shoulder instability,\n* Numbness or tingling in the upper extremity with cervical compression test or upper extremity compression test,\n* Systemic or neurological disease,\n* Corticosteroid injection within 3 months before the intervention,\n* Physical therapy in the 6 months before the intervention,\n* Those with a history of dislocation and subluxation,\n* Those who are pregnant,\n* Those who did not participate in the study for 2 consecutive sessions","35 Years",{"count":617,"type":20},38,[127],"Kettlebell exercises are seen as one of the approaches that can be used conservatively in individuals with shoulder pain. However, it is still unknown what results it has on its therapeutic effects. These findings highlight the need for higher quality studies evaluating the effects of kettlebell use and exercises for shoulder pain. Therefore, the purpose of this study was to investigate the effects of 8 weeks of kettlebell training on shoulder pain, function, and performance.\n\nThe hypotheses of our study are as follows:\n\n* H1: In individuals with Rotator Cuff-Related Shoulder Pain, the improvement in shoulder-related pain perception is greater with Kettlebell training compared to the standard rehabilitation program.\n* H2: In individuals with Rotator Cuff Related Shoulder Pain, shoulder function improvement is greater with Kettlebell training compared to the standard rehabilitation program.\n* H3: In individuals with Rotator Cuff-Related Shoulder Pain, shoulder performance improvement is greater with Kettlebell training than with the standard rehabilitation program.",[401,27],[622],"Kettlebell Exercises","2025-12-04",{"date":625,"type":33},"2025-12-17",{"date":627,"type":33},"2024-11-25",{"date":629,"type":20},"2026-04-01",{"name":631,"class":82},"Hacettepe University",{"id":633,"slug":4,"hasResults":11,"nctId":634,"briefTitle":635,"officialTitle":635,"acronym":4,"eligibilityCriteria":636,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":261,"enrollmentInfo":637,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":638,"conditions":639,"keywords":645,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":650,"lastUpdatePostDateStruct":651,"startDateStruct":653,"completionDateStruct":655,"leadSponsor":657,"locationsCount":83},"100378588","NCT04209504","Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block","Inclusion Criteria:\n\n* English speaking 18-80 year old ASA 1-3 patients\n* Primary shoulder surgery\n* Must live within a 25 mile radius\n\nExclusion Criteria:\n\n* ASA 4 or 5\n* Revision shoulder surgery\n* Diagnosis of chronic pain\n* Daily chronic opioid use (over 3 months of continuous opioid use)\n* Inability to communicate pain scores or need for analgesia\n* Infection at the site of block placement\n* Age under 18 years old or greater than 80 years old\n* Pregnant women (as determined by point-of-care serum bHCG)\n* Intolerance\u002Fallergy to local anesthetics\n* Weight \\\u003C50 kg\n* BMI \\> 40\n* severe pulmonary disease including chronic obstructive pulmonary disease and restrictive lung disease\n* Suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years.\n* Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, may interfere with study assessments or compliance.\n* Current or historical evidence of any clinically significant disease or condition that, in the opinion of the investigator, may increase the risk of surgery or complicate the subject's postoperative course.",{"count":231,"type":20},"This prospective observational study aims to evaluate the incidence of hemidiaphragmatic paralysis in patients receiving interscalene brachial plexus nerve block with prolonged neural blockade. English speaking American Society of Anesthesiologists (ASA) 1-3 patients ages 18-80 receiving prolonged interscalene nerve block will be randomized into 3 groups: first group receiving a perineural catheter infusing 0.2% ropivacaine; the second group receiving a single shot injection of 10mL liposomal bupivacaine (Exparel; n=20) plus 5 mL 0.5% bupivacaine and the third receiving 20mL liposomal bupivacaine plus 5mL bupivacaine (to be determined by the attending anesthesiologist).Primary outcome will be incidence of hemidiaphragmatic paralysis postoperative day 1 as measured by point of care (POCUS) ultrasound.",[640,401,57,641,642,26,27,643,644,181],"Shoulder Surgery","Shoulder Arthritis","Shoulder Disease","Rotator Cuff Arthropathy of Left Shoulder","Rotator Cuff Arthropathy of Right Shoulder",[181,640,646,647,648,649],"Hemidiaphragmatic paralysis","Interscalene Block","Interscalene Catheter","Interscalene Liposomal Bupivacaine","2025-09-29",{"date":652,"type":33},"2025-10-01",{"date":654,"type":33},"2021-10-12",{"date":656,"type":20},"2026-08-31",{"name":658,"class":82},"Duke University",{"id":660,"slug":4,"hasResults":11,"nctId":661,"briefTitle":662,"officialTitle":663,"acronym":664,"eligibilityCriteria":665,"healthyVolunteers":11,"sex":15,"minAge":425,"maxAge":4,"enrollmentInfo":666,"targetDuration":4,"studyType":21,"phases":668,"briefSummary":669,"conditions":670,"keywords":676,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":678,"lastUpdatePostDateStruct":679,"startDateStruct":681,"completionDateStruct":683,"leadSponsor":685,"locationsCount":608},"100603350","NCT07135375","Postoperative Rotator Cuff Rehabilitation: Functional, Pain and Sleep Quality","Postoperative Rotator Cuff: Functional, Pain and Sleep Quality","REHAB-PSF","Inclusion Criteria:\n\n* People over 50 years of age\n* People have undergone arthroscopic rotator cuff of one or more tendons.\n* Patients must sign informed consent and undergo physical therapy center (up to week 12 postoperatively).\n\nExclusion Criteria:\n\n* Patients who develop postoperative stiffness or adhesive capsulitis during the rehabilitation process.\n* Patients with symptoms of cervical radiculopathy or previously diagnosed sleep disorders.\n* Patients with neurological or cognitive disorders who have difficulty following instructions",{"count":667,"type":20},50,[127],"Rotator cuff injuries are the third leasing cause of pain and disability, accounting for 16% of all musculoskeletal injuries. Following surgical intervention, patients typically undergo a 4 to 6 week immobilization period before starting physical therapy. This rehabilitation phase can last between 4 to 6 months. Despite this, there is currently a lack of clear guidelines regarding specific physical therapy protocols or the expected post surgical recovery for patients who have undergone rotator cuff repair.",[27,671,672,673,674,675],"Functionality","Pain","Sleep","Rehabilitation","Rotator Cuff",[674,677],"Rotator cuff","2025-09-03",{"date":680,"type":33},"2025-09-10",{"date":682,"type":33},"2025-08-26",{"date":684,"type":20},"2026-03-30",{"name":686,"class":82},"LAURA CASTILLO VEJAR",""]