[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sdhx-related-syndromes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sdhx-related-syndromes":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100547471",false,"NCT06408402","Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers","Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas - National Study","PGLEXPO2","Inclusion Criteria:\n\n* Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor\n* Controls: SDHx mutation carriers with no SDHx-related tumor\n\nExclusion Criteria:\n\n* Incapacity to exercise free and informed consent for the study\n* Patient under tutorship or guardianship or legal safeguard","ALL","18 Years",{"count":19,"type":20},1300,"ESTIMATED","OBSERVATIONAL","The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and\u002For domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk.\n\nIn addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study",[24,25,26,27],"SDH-Related Familial Paraganglioma","SDHx-Related Syndromes","SDH Gene Mutation","Environmental Exposure",[29,30,31],"hereditary paraganglioma","SDHx gene mutation","environmental exposure","NOT_YET_RECRUITING","2024-05-06",{"date":35,"type":36},"2024-05-10","ACTUAL",{"date":38,"type":20},"2024-05-01",{"date":40,"type":20},"2028-05-01",{"name":42,"class":43},"Assistance Publique - Hôpitaux de Paris","OTHER",20,""]