[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-respiratory-distress-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-respiratory-distress-syndrome":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100581802",false,"NCT06855043","Little Lungs Study","Pilot Randomized Controlled Trial of Late Surfactant Therapy With Budesonide for Prevention of Bronchopulmonary Dysplasia","Neonate Inclusion Criteria:\n\n* Gestational age 22 0\u002F7 to 28 6\u002F7 weeks at birth\n* Age 7-14 days\n* Need invasive mechanical ventilatory support and a Fraction of Inspired Oxygen (FiO2) greater than or equal to 0.3\n\nBirthing Parent Inclusion Criteria:\n\n* Have a baby who meets neonate eligibility criteria and enrolls in the study.\n\nNeonate Exclusion Criteria:\n\n* Major congenital anomalies including congenital lung malformations and congenital diaphragmatic hernia and\u002For genetic disorders\n* Alternative, acute clinical etiology of respiratory deterioration or increased ventilatory requirements (e.g., sepsis, pneumonia, etc.)\n* History of pulmonary hemorrhage\n* Antibiotic use within 48 hours\n* Indomethacin or Ibuprofen use within 72 hours\n* Prior treatment with corticosteroids for prevention of lung disease\n* Not expected to survive for greater than 7 days at enrollment\n* Determined to be unstable by the clinical team\n* Enrolled in a conflicting clinical trial\n* Have a birth parent aged less than 18 years\n* Parent\u002Fguardian is unable to provide parental permission in English or Spanish","ALL","7 Days","14 Days",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","This clinical trial is being done to evaluate the safety and clinical response of late surfactant treatment with budesonide in extremely preterm infants requiring mechanical ventilation at 7-14 days of age.",[27,28],"Invasive Mechanical Ventilation","Severe Respiratory Distress Syndrome",[30],"premature birth","NOT_YET_RECRUITING","2026-01-23",{"date":34,"type":35},"2026-01-27","ACTUAL",{"date":37,"type":20},"2026-09",{"date":39,"type":20},"2029-03",{"name":41,"class":42},"University of Wisconsin, Madison","OTHER",2,""]