[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stage-ii-grade-b-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stage-ii-grade-b-periodontitis":51},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100609482",false,"NCT07215156","Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis","Comparative Study Between Metformin and Chlorhexidine Gel as Adjunctive to Conventional Non-Surgical Treatment of Stage II Grade B Periodontitis: A Randomized Controlled Clinical Trial","MET-CHX Perio","Inclusion Criteria:\n\nAdults aged 18-60 years.\n\nDiagnosis of Stage II, Grade B periodontitis.\n\nProbing pocket depths ≤ 5 mm with clinical attachment loss of 3-4 mm in selected sites.\n\nGenerally healthy individuals without systemic conditions affecting periodontal health.\n\nExclusion Criteria:\n\nCurrent smokers or users of tobacco products.\n\nPregnant or lactating women.\n\nKnown allergy to metformin or chlorhexidine.\n\nUse of antibiotics or anti-inflammatory drugs within the past 3 months.\n\nHistory of periodontal therapy within the past 6 months.","ALL","18 Years","60 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis. Periodontitis is a chronic inflammatory condition that damages the supporting tissues of the teeth. Although SRP is the standard non-surgical treatment, it may not fully eliminate harmful bacteria or prevent disease recurrence.\n\nChlorhexidine is a widely used antimicrobial gel, while metformin, a medication commonly prescribed for diabetes, has shown anti-inflammatory and bone-supportive effects when used locally in the gums. This study will directly compare the effectiveness of 1% metformin gel and 0.2% chlorhexidine gel, both applied subgingivally after SRP, against SRP alone.\n\nSixty adult participants diagnosed with Stage II, Grade B periodontitis will be randomly assigned into three groups: SRP only (control), SRP plus metformin gel, and SRP plus chlorhexidine gel. Clinical outcomes (plaque index, gingival index, probing pocket depth, and clinical attachment level), inflammatory markers (MMP-8 in gingival crevicular fluid), and radiographic bone density will be measured at baseline, 1 month, 3 months, and 6 months.\n\nThe goal is to determine whether metformin gel or chlorhexidine gel provides superior improvements in periodontal healing when compared with SRP alone. Findings from this trial may guide evidence-based decisions on optimizing non-surgical periodontal therapy.",[27,28],"Stage II, Grade B Periodontitis","Chronic Periodontitis",[30,31,28,32,33,34,35,36,37,38],"Periodontitis","Stage II Grade B Periodontitis","Scaling and Root Planing (SRP)","Non-surgical Periodontal Therapy","Metformin Gel","Chlorhexidine Gel","Local Drug Delivery","Periodontal Regeneration","Inflammatory Markers (MMP-8)","NOT_YET_RECRUITING","2025-10-02",{"date":42,"type":43},"2025-10-10","ACTUAL",{"date":45,"type":21},"2025-10-06",{"date":47,"type":21},"2026-06-01",{"name":49,"class":50},"Kafrelsheikh University","OTHER",""]