Subjective Memory Complaints

2

Review clinical trials related to Subjective Memory Complaints. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables

The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65 and older) residing in Italy and patients with dementia or Alzheimer's Disease. dNA is a questionnaire designed to assess both current and past levels of engagement in physical, cognitive, creative, and social activities. The study aims to recruit a total of 265 participants with mild cognitive impairment, subjective memory complaints, or dementia. These participants will be distributed among the 8 recruitment centers. Neuropsychological data, subjective measures, and MRI data will be collected and analyzed to address the following research questions: 1) Is there a positive correlation between scores on the dNA Scale and cognitive efficiency, as reflected in neuropsychological measures, such as episodic memory and executive functions? 2) Is there a correlation between dNA scores and improved functional connectivity within neural networks, such as the Default Network (DN)? Participants recruited at the participating clinical centers will undergo: * A clinical interview, during which demographic and medical history information will be collected. The dNA Scale will be administered, along with a questionnaire assessing adherence to dietary habits typical of a Mediterranean diet (14-Item Mediterranean Diet Adherence Screener; MEDAS). * A neuropsychological assessment, aimed at evaluating general cognitive function with a particular focus on episodic memory and executive functions. The following tests will be administered: Mini-Mental State Examination (MMSE) or, alternatively, Montreal Cognitive Assessment (MoCA); Rey Auditory Verbal Learning Test (RAVLT); Trial Making Test (TMT) Form B; Digit Span Forward and Backward (WAIS or WAIS-III); and the Stroop Test. * Self-report questionnaires designed to assess depressive symptoms using the Geriatric Depression Scale (GDS) and anxiety symptoms using the Geriatric Anxiety Scale (GAS) (or alternatively the State-Trait Anxiety Inventory, STAI). Finally, the Cognitive Reserve Index Questionnaire will be administered to estimate Cognitive Reserve (CRIq). * Where available, MRI data previously acquired for clinical or diagnostic purposes will be included in the study and analyzed by the principal investigator.

Participants needed: 265
Trial details
Age: 65+Biological sex: AllType: ObservationalSponsor: Neuromed IRCCSUpdated: Jun 11, 2026Locations: 8Duration: 1 Year
Eligibility criteria

Individuals aged ≥ 65 years residing in Italy; [+29]

Individuals aged < 65 years; [+3]

Status: Recruiting

Testing the Cog-Fun Aging Program for Older Adults With Subjective Cognitive Decline

The goal of this clinical trial is to learn if the Cog-Fun Aging program helps older adults with Subjective Cognitive Decline (SCD) manage memory challenges and improve their daily lives. The main questions it aims to answer are: * Does the program help participants better understand their cognitive challenges in daily life? * Do participants report using more effective strategies to manage their memory difficulties? * Does the Cog-Fun Aging program reduce negative emotions and self-perceptions related to SCD? Researchers will compare participants who complete the Cog-Fun Aging program with those who do not to determine the program's effectiveness. Participants will: Take part in a 10-week program with weekly sessions. Learn about SCD and how it affects daily life. Practice and monitor strategies to manage memory difficulties.

Participants needed: 40
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: Hebrew University of JerusalemUpdated: Feb 12, 2025Locations: 3
Eligibility criteria

experiencing memory changes and feeling concerned about them [+2]

a self-reported health condition that significantly impacts functioning (e.g., u... [+2]