[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"systemic-inflammation-hscrp\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:systemic-inflammation-hscrp":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100645084",false,"NCT07678346","Evaluation of AppleX™ Apple Extract on Anti-Inflammatory and Healthy Aging Effects","A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Anti-Inflammatory and Healthy Aging Effects of AppleX™ Apple Extract (15% Fisetin) in Adults 45-70 Years of Age","Inclusion Criteria:\n\n* Age 45-70 years at time of enrollment\n* Meets questionnaire-based inflammatory enrichment criteria (at least 2 of 5 risk factors, per Section 4.2)\n* Non-smoker (no tobacco or nicotine use within 6 months of enrollment)\n* Willing and able to maintain stable diet, exercise habits, and supplement use throughout the 24-week study period\n* No major medication changes planned during the study period\n* Willing to perform home-based DBS collections at T0, T12, and T24\n* Access to a smartphone or computer to complete eConsent and online questionnaires\n* Able to provide informed consent via the Alethios eConsent platform\n\nExclusion Criteria:\n\n* Current use of prescription anti-inflammatory medications including NSAIDs (regular use ≥3x\u002Fweek), corticosteroids, or DMARDs\n* Diagnosis of an autoimmune or inflammatory disease (e.g., rheumatoid arthritis, lupus, IBD, multiple sclerosis)\n* Active or unstable cardiovascular disease requiring medication changes during the study period\n* History of cancer within the past 5 years (except non-melanoma skin cancer)\n* Regular use of supplemental fisetin, quercetin, or resveratrol within 30 days of enrollment\n* Pregnancy, breastfeeding, or planning to become pregnant during the study\n* Known allergy to apple or apple-derived products\n* Body mass index (BMI) \\>40 kg\u002Fm²",true,"ALL","45 Years","70 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if AppleX™ Apple Extract can help lower systemic inflammation in adults aged 45-70 with signs of low-grade inflammation. It will also look at the extract's effects on fatigue, joint comfort, and biological aging metrics.\n\nThe main questions it aims to answer are:\n\n* Does taking AppleX™ Apple Extract daily lower high-sensitivity C-reactive protein (hsCRP) levels, a key marker of inflammation in the blood?\n* Does AppleX™ Apple Extract improve participant-reported fatigue and joint comfort?\n* Does the extract slow down biological or epigenetic aging metrics compared to a placebo?\n\nResearchers will compare AppleX™ Apple Extract to a placebo (a look-alike capsule that contains no active ingredients) to see if the apple extract has a measurable anti-inflammatory and healthy aging effect.",[27,28,29,30],"Systemic Inflammation (hsCRP)","Healthy Aging","Vitality","Healthy Adult Participants",[32,33,34,35],"Apple extract","Fisetin","Flavonoids","polyphenols","NOT_YET_RECRUITING","2026-06-25",{"date":39,"type":40},"2026-07-01","ACTUAL",{"date":42,"type":21},"2026-07",{"date":44,"type":21},"2027-02",{"name":46,"class":47},"Nutraland USA, Inc.","INDUSTRY",""]