[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tooth-staining\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tooth-staining":52},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100628634",false,"NCT07464197","Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized Nightguards","Evaluation of the Effectiveness in Dental Bleaching by Different Designs of 3D-Printed Digital Customized Nightguards","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Good general and oral health\n* No current medical treatment (self-reported)\n* No need for surgical, endodontic, periodontal, or restorative dental treatment\n* At least six upper and six lower anterior teeth free of caries and restorations\n* Maxillary central incisors with baseline shade A2 or darker\n* Willingness to follow the study protocol and use the study-provided oral hygiene products\u002Finstructions\n\nExclusion Criteria:\n\n* Previous tooth bleaching treatment\n* Orthodontic appliances or prostheses that interfere with treatment\n* Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)\n* Pregnancy or lactation\n* Bruxism\n* Gingival recession, dentin exposure, visible enamel cracks, or other conditions associated with increased sensitivity\n* Use of anti-inflammatory or analgesic medication during the study period (according to protocol)",true,"ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.",[26,27],"Tooth Discoloration","Tooth Staining",[29,30,31,32,33,34,35,36,37,38,39],"dental bleaching","custom tray","3D-printed tray","CAD-CAM","Carbamide peroxide","Nightguard vital bleaching","Tooth sensitivity","Gingival irritation","Spectrophotometer","Split-mouth trial","tooth whitening","RECRUITING","2026-03-11",{"date":43,"type":44},"2026-03-16","ACTUAL",{"date":46,"type":44},"2022-05-01",{"date":48,"type":20},"2026-07",{"name":50,"class":51},"Universitat Internacional de Catalunya","OTHER",""]